Metabolism articles from across Nature Portfolio

Metabolism refers to the chemical reactions that occur within an organism to sustain life. The reactions are divided into two categories: catabolism (the breakdown of organic matter to produce energy); and anabolism (the construction of molecules from smaller units).


Latest Research and Reviews

News and Comment

  • News & Views |

    Animals need to be able to evaluate environmental pH. Mechanisms that mediate sour taste and acid sensing have been reported across species, but less is known about the detection of high pH. Mi et al. identify the gene alkaliphile, which encodes a high-pH-gated chloride channel in the gustatory system of flies.

    • Scarlet J. Park
    •  & William W. Ja
  • News & Views |

    Defective nicotinamide adenine dinucleotide (NAD+) metabolism is involved in various diseases. A study in Nature Metabolism identifies the cytosolic mitochondrial-RNA sensing system as a mediator that links NAD+ deficiency to kidney disease in humans and mice.

    • Hiroshi Itoh
    •  & Jun Yoshino
  • News & Views |

    Cellular organelles called mitochondria contain their own DNA and RNA. The molecule fumarate has now been found to trigger the release of these nucleic acids into the cytosol, aberrantly activating inflammation.

    • Taylor A. Poor
    •  & Navdeep S. Chandel
    Nature 615, 401-402
  • Comments & Opinion |

    The field of bioenergetics is rapidly expanding with new discoveries of mechanisms and potential therapeutic targets. The 2023 Keystone symposium on ‘Bioenergetics in Health and Disease’, which was jointly held with the symposium ‘Adipose Tissue: Energizing Good Fat’, consisted of a powerhouse line-up of researchers who shared their insights.

    • Melia Granath-Panelo
    • , Anna Krook
    •  & Shingo Kajimura