Metabolic engineering articles from across Nature Portfolio

Metabolic engineering is the use of genetic engineering to modify the metabolism of an organism. It can involve the optimization of existing biochemical pathways or the introduction of pathway components, most commonly in bacteria, yeast or plants, with the goal of high-yield production of specific metabolites for medicine or biotechnology.

Latest Research and Reviews

News and Comment

  • News & Views |

    Comamonas testosteroni utilizes aromatic compounds such as monomers from lignin and plastics, but the underlying metabolic pathways were elusive. Multi-omics analysis now clarifies the multifaceted regulation of its metabolism, facilitating strain engineering to convert substrates from lignin and plastics into valuable bioproducts.

    • Yinjie J. Tang
    •  & Tae Seok Moon
  • News & Views |

    Most engineered bacteria are designed to grow and function in a free-swimming state. A new method enables engineered bacteria to reversibly transition into a biofilm state.

    • Anita Silver
    •  & Lingchong You
  • News & Views |

    Inspired by nature, a synthetic carbon fixation cycle builds complex molecules directly from CO2. Building metabolism from the ground up requires several innovative advancements — now, a strategy to balance carbon demands in a complex metabolic network is explored.

    • Grant M. Landwehr
    •  & Michael C. Jewett