Metabolic engineering

Metabolic engineering is the use of genetic engineering to modify the metabolism of an organism. It can involve the optimization of existing biochemical pathways or the introduction of pathway components, most commonly in bacteria, yeast or plants, with the goal of high-yield production of specific metabolites for medicine or biotechnology.

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News and Comment

  • Comments and Opinion | | open

    Biofoundries provide an integrated infrastructure to enable the rapid design, construction, and testing of genetically reprogrammed organisms for biotechnology applications and research. Many biofoundries are being built and a Global Biofoundry Alliance has recently been established to coordinate activities worldwide.

    • Nathan Hillson
    • , Mark Caddick
    • , Yizhi Cai
    • , Jose A. Carrasco
    • , Matthew Wook Chang
    • , Natalie C. Curach
    • , David J. Bell
    • , Rosalind Le Feuvre
    • , Douglas C. Friedman
    • , Xiongfei Fu
    • , Nicholas D. Gold
    • , Markus J. Herrgård
    • , Maciej B. Holowko
    • , James R. Johnson
    • , Richard A. Johnson
    • , Jay D. Keasling
    • , Richard I. Kitney
    • , Akihiko Kondo
    • , Chenli Liu
    • , Vincent J. J. Martin
    • , Filippo Menolascina
    • , Chiaki Ogino
    • , Nicola J. Patron
    • , Marilene Pavan
    • , Chueh Loo Poh
    • , Isak S. Pretorius
    • , Susan J. Rosser
    • , Nigel S. Scrutton
    • , Marko Storch
    • , Hille Tekotte
    • , Evelyn Travnik
    • , Claudia E. Vickers
    • , Wen Shan Yew
    • , Yingjin Yuan
    • , Huimin Zhao
    •  & Paul S. Freemont
  • News and Views |

    Terpenoids are assembled from five-carbon (C5) units, which limits the available scaffold chemical space for the discovery of bioactive molecules. A combination of enzyme and metabolic engineering now enables biosynthesis of a plethora of non-natural C11 terpenoids.

    • Yongjin J. Zhou
    Nature Chemical Biology 14, 1069-1070
  • News and Views |

    A new pyrrolysyl-tRNA synthetase/PyltRNA (PylRS/PyltRNA) pair that is mutually orthogonal to existing PylRS/PyltRNA pairs has now been discovered and optimized. This system could enable the site-specific incorporation of a greater number of distinct non-canonical amino acids into a protein.

    • William S. C. Ngai
    •  & Peng R. Chen
    Nature Chemistry 10, 802-803