Metabolic diseases articles from across Nature Portfolio

Metabolic diseases occur when the body's usual metabolic processes are disrupted. These diseases can be congenital or acquired, for example, diabetes and phenylketonuria.

Latest Research and Reviews

Research
30 May 2023 | Open Access

Transcriptional coactivation by EHMT2 restricts glucocorticoid-induced insulin resistance in a study with male mice

Glucocorticoids are known to induce insulin resistance via transcriptional activation of genes related to liver gluconeogenesis and insulin resistance. Here the authors report that in male mice treated with glucocorticoids, the transcriptional co-regulator EHMT2 is involved in the induction of Irs2 (a gene promoting insulin action) to restrict the extent of insulin resistance in the liver.
- Rebecca A. Lee
- , Maggie Chang
- & Jen-Chywan Wang
Nature Communications 14, 3143
Research
23 May 2023 | Open Access

PCr/ATP ratios and mitochondrial function in the heart. A comparative study in humans
- Vera H. W. de Wit-Verheggen
- , Vera B. Schrauwen-Hinderling
- & Tineke van de Weijer
Scientific Reports 13, 8346
Research
15 May 2023 | Open Access

SIRT2 regulates extracellular vesicle-mediated liver–bone communication

Lin et al. show that small extracellular vesicles derived from SIRT2-deficient hepatocytes inhibit osteoclast differentiation from mouse and human bone-marrow-derived monocytes and alleviate bone loss in mouse models of osteoporosis.
- Longshuai Lin
- , Zengya Guo
- & Qinghua Zhao
Nature Metabolism 5, 821-841
Research
12 May 2023 | Open Access

Genetically prolonged beige fat in male mice confers long-lasting metabolic health

Beige adipocytes quickly transition into white adipocytes upon the removal of stimuli, limiting their therapeutic potential for chronic metabolic diseases. In this study, the authors show that inhibiting Cdkn2a-Becn1 mediated autophagy can maintain beige adipocytes and provide long term metabolic health benefits in mice.
- Ruifan Wu
- , Jooman Park
- & Yuwei Jiang
Nature Communications 14, 2731
Research
01 May 2023 | Open Access

Candesartan, an angiotensin-II receptor blocker, ameliorates insulin resistance and hepatosteatosis by reducing intracellular calcium overload and lipid accumulation
- Jin Wook Lee
- , Hyun-Oh Gu
- & Byung-Chul Oh
Experimental & Molecular Medicine, 1-16
Research
29 April 2023 | Open Access

Acute effect of moderate and high-intensity interval exercises on asprosin and BDNF levels in inactive normal weight and obese individuals
- Halil İbrahim Ceylan
- , Mehmet Ertuğrul Öztürk
- & Hadi Nobari
Scientific Reports 13, 7040

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News and Comment

Research Highlights | 17 May 2023

The kidney is a novel target of metformin
- Ellen F. Carney
Nature Reviews Nephrology, 1
Correspondence | 15 May 2023

Single-cell expression profiling of islets generated by the Human Pancreas Analysis Program
- Abhijeet R. Patil
- , Jonathan Schug
- & Golnaz Vahedi
Nature Metabolism 5, 713-715
News & Views | 27 April 2023

A guide from the stomach to β cells

Direct conversions offer an alternative approach to generate insulin-producing cells for cell therapy in diabetes. A study reports a method to convert human stomach-derived gastric stem cells into functional insulin-producing cells through a unique differentiation path.
- Jinhyuk Choi
- , Fritz Cayabyab
- & Eiji Yoshihara
Nature Cell Biology 25, 637-638
News & Views | 13 April 2023

Overlooked confounding in studies of metabolite salts

Metabolites have emerged as important signalling molecules, and their biological effects are frequently investigated by treating animals and cells with solutions of commercially available metabolite salts. Such experiments require proper controls for osmolarity and the presence of counterions, as illustrated by dramatic confounding effects on energy balance in studies with sodium l-lactate.

Nature Metabolism 5, 542-543
News & Views | 06 April 2023

XOR risk variants drive diabetic kidney disease

Diabetic kidney disease is influenced by a combination of genetic and environmental factors. A study identifies risk variants in the XOR promoter that elevate its own activity in response to hyperglycaemia, which has a causative role in the onset and progression of diabetic kidney disease.
- Ke Zhu
- & Jochen Reiser
Nature Metabolism 5, 536-537
Research Highlights | 28 March 2023

GLP1R agonists in NAFLD: a promising therapy on the horizon
- Rula Bany Bakar
Nature Reviews Gastroenterology & Hepatology 20, 346

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Metabolic diseases articles from across Nature Portfolio

Latest Research and Reviews

Transcriptional coactivation by EHMT2 restricts glucocorticoid-induced insulin resistance in a study with male mice

PCr/ATP ratios and mitochondrial function in the heart. A comparative study in humans

SIRT2 regulates extracellular vesicle-mediated liver–bone communication

Genetically prolonged beige fat in male mice confers long-lasting metabolic health

Candesartan, an angiotensin-II receptor blocker, ameliorates insulin resistance and hepatosteatosis by reducing intracellular calcium overload and lipid accumulation

Acute effect of moderate and high-intensity interval exercises on asprosin and BDNF levels in inactive normal weight and obese individuals

News and Comment

The kidney is a novel target of metformin

Single-cell expression profiling of islets generated by the Human Pancreas Analysis Program

A guide from the stomach to β cells

Overlooked confounding in studies of metabolite salts

XOR risk variants drive diabetic kidney disease

GLP1R agonists in NAFLD: a promising therapy on the horizon

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Metabolic diseases articles from across Nature Portfolio

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