Menopause articles from across Nature Portfolio

A new study in Nature reports a large-scale genome-wide association study of menopause timing, revealing mechanistic details and potential therapeutic opportunities for preserving human fertility.

Myriad genetic and biological factors control the timing of menopause—understanding these has implications for fertility and health.

Finnish women <60 years old have an increased risk of death from cardiac events or stroke within a year of stopping hormone-replacement therapy (HRT), compared with women who have not had HRT and with those on current therapy. The safety of the practice of annual discontinuation of HRT should be questioned.