Membrane fission articles within Nature Communications

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  • Article
    | Open Access

    Structural and functional studies highlight the molecular regulation of assembling the mitochondrial division machinery. The core unit is closed, and specific interactions open this unit to facilitate assembly at the right place and time in cells.

    • Kristy Rochon
    • , Brianna L. Bauer
    •  & Jason A. Mears

  • Article
    | Open Access

    It is estimated that about 80% of endocytosed material is recycled back to the plasma membrane. Here, the authors show that kiss-and-run of Rab5 early endocytic and Rab11 recycling vesicles on sorting endosomes allow cargo flow, providing more robustness and fidelity to the sorting process.

    • Jachen A. Solinger
    • , Harun-Or Rashid
    •  & Anne Spang

  • Article
    | Open Access

    Dynamin mediates the fission of vesicles during endocytosis. Here, the authors report the cryoEM structure of a super-constricted two-start dynamin 1 filament- one of the two known helical forms of dynamin, with insights into the molecular mechanisms of dynamin-mediated membrane scission.

    • Jiwei Liu
    • , Frances Joan D. Alvarez
    •  & Peijun Zhang

  • Article
    | Open Access

    Salmonella secretes the effector protein SopD into the host cell cytoplasm, leading to scission of the plasma membrane through unclear mechanisms. Here, Boddy et al. show that SopD binds to and inhibits the small GTPase Rab10, thus promoting removal of Rab10 and recruitment of dynamin-2 to drive plasma membrane scission.

    • Kirsten C. Boddy
    • , Hongxian Zhu
    •  & John H. Brumell

  • Article
    | Open Access

    Endocytosis mediates the cellular uptake of micronutrients and cell surface proteins. Here, the authors show that Cdk5 and GSK3β are negative regulators of fast Endophilin-mediated endocytosis (FEME).

    • Antonio P. A. Ferreira
    • , Alessandra Casamento
    •  & Emmanuel Boucrot

  • Article
    | Open Access

    Intracellular vesicle transport can be regulated by Brefeldin‐A ADP‐Ribosylated Substrate (BARS) during vesicle fission. Here, the authors show that NADH generated by aldehyde dehydrogenase 7A1 (ALDH7A1) inhibits intracellular transport by targeting BARS and inhibiting COPI vesicle fission during situations of energy deprivation

    • Jia-Shu Yang
    • , Jia-Wei Hsu
    •  & Victor W. Hsu

  • Article
    | Open Access

    Drp1 and Dnm2 have been implicated in mitochondrial fission events, although their specific activities in constriction and scission have been unclear. Here, the authors demonstrate that Drp1 is sufficient to constrict and sever mitochondrial and peroxisomal membranes in the absence of Dnm proteins.

    • Sukrut C. Kamerkar
    • , Felix Kraus
    •  & Michael T. Ryan

  • Article
    | Open Access

    The GTPase dynamin catalyzes membrane fission but activity of the dynamin-related ATPase EHD1 is unknown. Here, using in vitro reconstitution assays and molecular dynamics simulations, the authors report that EHD1 hydrolyzes ATP to remodel, causing fission of membrane tubes and that this is necessary for endocytic recycling.

    • Raunaq Deo
    • , Manish S. Kushwah
    •  & Thomas J. Pucadyil

  • Article
    | Open Access

    Membrane fusion and fission events at exoplasmic membrane surfaces are not well understood. Here the authors show that the C. elegans cell–cell fusogen AFF-1 is required for endocytic scission and apically-directed membrane trafficking during the development of a unicellular tube.

    • Fabien Soulavie
    • , David H. Hall
    •  & Meera V. Sundaram

  • Article
    | Open Access

    Actin and microtubules play important roles in Golgi structure and function but how they are connected is poorly understood. Here the authors show that KIF20A is involved in the fission process and, in association with Myosin II, serves to anchor RAB6 on Golgi/TGN membranes near microtubules nucleating sites.

    • Stéphanie Miserey-Lenkei
    • , Hugo Bousquet
    •  & Bruno Goud

  • Article
    | Open Access

    CtBP1-S/BARS is required for fission of endomembrane compartments including the Golgi. Here the authors show that CtBP1-S/BARS activates a trans-Golgi lysophosphatidic acid acyltransferase that catalyses the production of phosphatidic acid and is required for fission of the post-Golgi carrier membrane.

    • Alessandro Pagliuso
    • , Carmen Valente
    •  & Alberto Luini

  • Article
    | Open Access

    Streptomycetes are multicellular bacteria that grow as multinucleoid filaments with infrequent cross-walls. Here, the authors describe a membrane system that forms protein-impermeable barriers and compartmentalizes the multinucleoid filaments independently from the FtsZ-guided cell division machinery.

    • Katherine Celler
    • , Roman I. Koning
    •  & Gilles P. van Wezel

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