Membrane curvature articles within Nature Communications

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  • Article
    | Open Access

    How membrane morphology is regulated during autophagosome formation remains elusive. Here, authors reveal a mechanism by which the forming autophagosomal membrane expands with a large opening for non-selective sequestration of the cytoplasm.

    • Tetsuya Kotani
    • , Yuji Sakai
    •  & Hitoshi Nakatogawa

  • Article
    | Open Access

    The role of actin filaments in clathrin-mediated endocytosis (CME) is unclear. Here, Yang et al. show that branched actin filaments promote CME by pushing on clathrin coat edges in an epsin-dependent manner, dividing large flat clathrin plaques into sizes that facilitate invagination.

    • Changsong Yang
    • , Patricia Colosi
    •  & Tatyana Svitkina

  • Article
    | Open Access

    Lysine acetylation regulates the function of soluble proteins in vivo, yet it remains largely unexplored whether lysine acetylation regulates the function of membrane proteins. Here, the authors map lysine acetylation predominantly in membrane-interaction regions in peripheral membrane proteins and show with three candidate proteins how lysine acetylation is a regulator of membrane protein function.

    • Alan K. Okada
    • , Kazuki Teranishi
    •  & Ralf Langen

  • Article
    | Open Access

    The COPII coat assembles in two concentric layers and mediates protein export from the endoplasmic reticulum. Here the authors present the 4.9 Å resolution cryo-tomography and subtomogram averaging structure of the membrane bound COPII inner coat that was obtained by in vitro reconstitution and discuss mechanistic implications.

    • Joshua Hutchings
    • , Viktoriya Stancheva
    •  & Giulia Zanetti

  • Article
    | Open Access

    Several endocytic pathways operate simultaneously at the cell surface, including the clathrin and dynamin-independent CLIC/GEEC (CG) pathway. Here the authors show that small GTPases and BAR domain proteins regulate branched actin to make clathrin and dynamin-independent endocytic vesicles.

    • Mugdha Sathe
    • , Gayatri Muthukrishnan
    •  & Satyajit Mayor

  • Article
    | Open Access

    The role of annexins in cell membrane repair is largely undefined. Here the authors use a model lipid bilayer to show that annexin A4 induces curvature at the membrane free edge and annexin A6 induces constriction force, and find that both annexins are recruited to wound edges in cells and are required for repair.

    • Theresa Louise Boye
    • , Kenji Maeda
    •  & Jesper Nylandsted

  • Article
    | Open Access

    HER2 is frequently overexpressed in breast cancer in association with increased metastatic potential. Here, the authors show that HER2 overexpression causes deformation of cell membranes in a signalling-independent manner that contributes to the disease phenotype by disrupting epithelial features.

    • Inhee Chung
    • , Mike Reichelt
    •  & Mark X. Sliwkowski

  • Article
    | Open Access

    The inverted-BAR domain protein IRSp53 associates with the inner leaflet of tubular membranes such as filopodia. Here, Prévostet al. demonstrate that the I-BAR domain of IRSp53 senses negative membrane curvature, and undergoes phase separation which may aid its clustering upon filopodia generation.

    • Coline Prévost
    • , Hongxia Zhao
    •  & Patricia Bassereau

  • Article
    | Open Access

    Proteins that bend membranes often contain curvature-promoting structural motifs such as wedges or crescent-shaped domains. Busch et al.report that intrinsically disordered domains can also drive membrane curvature and provide evidence that steric pressure driven by protein crowding mediates this effect.

    • David J. Busch
    • , Justin R. Houser
    •  & Jeanne C. Stachowiak

  • Article
    | Open Access

    BAR domain proteins are known to reshape cell membranes. Using coarse-grained molecular dynamics simulations, Simunovic and Voth demonstrate that membrane tension strongly affects the association of BAR proteins, in turn controlling their recruitment to membrane-remodelling sites.

    • Mijo Simunovic
    •  & Gregory A. Voth

  • Article |

    Complexin binds to synaptic vesicles and inhibits spontaneous exocytosis. Here Snead et al. show that the high curvature of the vesicle membrane is important for membrane binding, and induces a conformational change that is important for complexin’s inhibitory function.

    • David Snead
    • , Rachel T. Wragg
    •  & David Eliezer

  • Article |

    Membrane curvature and lipid composition direct the binding of many peripheral membrane proteins. Here, Vanni et al. use a combination of in vitroand molecular dynamics approaches to quantify how lipid-packing defects in membranes of various composition and curvature dictate the membrane adsorption of a model lipid-binding protein.

    • Stefano Vanni
    • , Hisaaki Hirose
    •  & Romain Gautier

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