Medical research articles from across Nature Portfolio

Improving HIV interventions for men could reduce HIV acquisition in women, close the growing gender gap in HIV infections and further reduce HIV incidence in African countries.

Research participants often do not represent the target population for treatment. Systematic exclusion of particular groups limits the generalizability of research and perpetuates health inequalities. The REP-EQUITY toolkit guides representative and equitable inclusion in research. Its use may promote trust between communities and research institutions and improve the applicability of research findings.

The year 2023 brought reports of highly effective glucagon-like peptide 1 (GLP1) mono-agonists or combinations with amylin receptor agonists. Results for monomolecular co-agonists that added glucagon receptor and/or glucose-dependent insulinotropic polypeptide (GIP) receptor agonism to GLP1 receptor activation were also published in 2023. Interestingly, antagonistic GIP receptor antibodies conjugated with a GLP1 agonist were also shown to be effective.

Improving HIV interventions for men could reduce HIV acquisition in women, close the growing gender gap in HIV infections and further reduce HIV incidence in African countries.

Research participants often do not represent the target population for treatment. Systematic exclusion of particular groups limits the generalizability of research and perpetuates health inequalities. The REP-EQUITY toolkit guides representative and equitable inclusion in research. Its use may promote trust between communities and research institutions and improve the applicability of research findings.

Academic research plays a central role in the translational ecosystem, sitting on one end of the valley of death, that is, the gap between preclinical research and real-world clinical applications. Considering clinical need and applicability early in research and development, and knowing about regulatory and commercialization processes, may help academics push innovations across the valley.