Medical research

  • Article | | open

    FXR1P is a RNA binding protein involved in muscle development. Here, the authors show that mutations in FXR1 exon 15, which is alternatively spliced in muscle, cause multi-minicore myopathy in humans and in mouse models.

    • María Cristina Estañ
    • , Elisa Fernández-Núñez
    • , Maha S. Zaki
    • , María Isabel Esteban
    • , Sandra Donkervoort
    • , Cynthia Hawkins
    • , José A. Caparros-Martin
    • , Dimah Saade
    • , Ying Hu
    • , Véronique Bolduc
    • , Katherine Ru-Yui Chao
    • , Julián Nevado
    • , Ana Lamuedra
    • , Raquel Largo
    • , Gabriel Herrero-Beaumont
    • , Javier Regadera
    • , Concepción Hernandez-Chico
    • , Eduardo F. Tizzano
    • , Victor Martinez-Glez
    • , Jaime J. Carvajal
    • , Ruiting Zong
    • , David L. Nelson
    • , Ghada A. Otaify
    • , Samia Temtamy
    • , Mona Aglan
    • , Mahmoud Issa
    • , Carsten G. Bönnemann
    • , Pablo Lapunzina
    • , Grace Yoon
    •  & Victor L. Ruiz-Perez
  • Article | | open

    Here, the authors explore the relationship between socioeconomic position (SEP) across the life course and inflammation in a multi-cohort study and show that educational attainment is most strongly related to inflammation, suggesting that socioeconomic disadvantage in young adulthood is independently associated with later life inflammation.

    • Eloïse Berger
    • , Raphaële Castagné
    • , Marc Chadeau-Hyam
    • , Murielle Bochud
    • , Angelo d’Errico
    • , Martina Gandini
    • , Maryam Karimi
    • , Mika Kivimäki
    • , Vittorio Krogh
    • , Michael Marmot
    • , Salvatore Panico
    • , Martin Preisig
    • , Fulvio Ricceri
    • , Carlotta Sacerdote
    • , Andrew Steptoe
    • , Silvia Stringhini
    • , Rosario Tumino
    • , Paolo Vineis
    • , Cyrille Delpierre
    •  & Michelle Kelly-Irving
  • Article | | open

    Negative selection removes deleterious genetic variation, and can influence genetic architectures and evolution of complex traits. Here, the authors analyze data from 25 UK Biobank diseases and complex traits, and quantify frequency-dependent genetic architectures which suggests actions of negative selection.

    • Armin P. Schoech
    • , Daniel M. Jordan
    • , Po-Ru Loh
    • , Steven Gazal
    • , Luke J. O’Connor
    • , Daniel J. Balick
    • , Pier F. Palamara
    • , Hilary K. Finucane
    • , Shamil R. Sunyaev
    •  & Alkes L. Price
  • Article | | open

    Sex-stratified medicine is an important and understudied field. Here the authors investigate in a systematic study of the Danish population differences in incidence, risk, and several aspects of diagnoses between sexes and find differences across all areas of disease.

    • David Westergaard
    • , Pope Moseley
    • , Freja Karuna Hemmingsen Sørup
    • , Pierre Baldi
    •  & Søren Brunak
  • Article | | open

    Diverse interactions between the nervous and immune systems have been shown, but specific mechanistic insights are still lacking. Here the authors show, using both mouse inflammation models and clinical correlation, that adrenergic nerve may ameliorate inflammation by inducing repulsive guidance molecule A signalling.

    • Andreas Körner
    • , Martin Schlegel
    • , Torsten Kaussen
    • , Verena Gudernatsch
    • , Georg Hansmann
    • , Timo Schumacher
    • , Martin Giera
    •  & Valbona Mirakaj
  • Article | | open

    It is unclear whether the sequence and timing of early life neurodevelopment varies across human populations, excluding the effects of disease or malnutrition. Here, the authors show that children of healthy, urban, educated mothers show very similar development across five geographically diverse populations.

    • José Villar
    • , Michelle Fernandes
    • , Manorama Purwar
    • , Eleonora Staines-Urias
    • , Paola Di Nicola
    • , Leila Cheikh Ismail
    • , Roseline Ochieng
    • , Fernando Barros
    • , Elaine Albernaz
    • , Cesar Victora
    • , Naina Kunnawar
    • , Sophie Temple
    • , Francesca Giuliani
    • , Tamsin Sandells
    • , Maria Carvalho
    • , Eric Ohuma
    • , Yasmin Jaffer
    • , Alison Noble
    • , Michael Gravett
    • , Ruyan Pang
    • , Ann Lambert
    • , Enrico Bertino
    • , Aris Papageorghiou
    • , Cutberto Garza
    • , Alan Stein
    • , Zulfiqar Bhutta
    •  & Stephen Kennedy
  • Article | | open

    Seasonal malaria chemoprevention provides substantial benefit for young children, but resistance to used drugs will likely develop. Here, Chotsiri et al. evaluate the use of dihydroartemisinin-piperaquine as a regimen in 179 children, and population-based simulations suggest that small children would benefit from a higher and extended dosage.

    • Palang Chotsiri
    • , Issaka Zongo
    • , Paul Milligan
    • , Yves Daniel Compaore
    • , Anyirékun Fabrice Somé
    • , Daniel Chandramohan
    • , Warunee Hanpithakpong
    • , François Nosten
    • , Brian Greenwood
    • , Philip J. Rosenthal
    • , Nicholas J. White
    • , Jean-Bosco Ouédraogo
    •  & Joel Tarning
  • Article | | open

    Organs from donors with transmissible viral infections, such as hepatitis C virus (HCV), are not offered for transplantation due to a high risk of transmission. Here, Galasso et al. develop a method for treatment of HCV-infected human donor lungs that is safe and prevents HCV transmission in the pig model.

    • Marcos Galasso
    • , Jordan J. Feld
    • , Yui Watanabe
    • , Mauricio Pipkin
    • , Cara Summers
    • , Aadil Ali
    • , Robert Qaqish
    • , Manyin Chen
    • , Rafaela V. P. Ribeiro
    • , Khaled Ramadan
    • , Layla Pires
    • , Vanderlei S. Bagnato
    • , Cristina Kurachi
    • , Vera Cherepanov
    • , Gray Moonen
    • , Anajara Gazzalle
    • , Thomas K. Waddell
    • , Mingyao Liu
    • , Shaf Keshavjee
    • , Brian C. Wilson
    • , Atul Humar
    •  & Marcelo Cypel
  • Article | | open

    Similarities in cancers can be studied to interrogate their etiology. Here, the authors use genome-wide association study summary statistics from six cancer types based on 296,215 cases and 301,319 controls of European ancestry, showing that solid tumours arising from different tissues share a degree of common germline genetic basis.

    • Xia Jiang
    • , Hilary K. Finucane
    • , Fredrick R. Schumacher
    • , Stephanie L. Schmit
    • , Jonathan P. Tyrer
    • , Younghun Han
    • , Kyriaki Michailidou
    • , Corina Lesseur
    • , Karoline B. Kuchenbaecker
    • , Joe Dennis
    • , David V. Conti
    • , Graham Casey
    • , Mia M. Gaudet
    • , Jeroen R. Huyghe
    • , Demetrius Albanes
    • , Melinda C. Aldrich
    • , Angeline S. Andrew
    • , Irene L. Andrulis
    • , Hoda Anton-Culver
    • , Antonis C. Antoniou
    • , Natalia N. Antonenkova
    • , Susanne M. Arnold
    • , Kristan J. Aronson
    • , Banu K. Arun
    • , Elisa V. Bandera
    • , Rosa B. Barkardottir
    • , Daniel R. Barnes
    • , Jyotsna Batra
    • , Matthias W. Beckmann
    • , Javier Benitez
    • , Sara Benlloch
    • , Andrew Berchuck
    • , Sonja I. Berndt
    • , Heike Bickeböller
    • , Stephanie A. Bien
    • , Carl Blomqvist
    • , Stefania Boccia
    • , Natalia V. Bogdanova
    • , Stig E. Bojesen
    • , Manjeet K. Bolla
    • , Hiltrud Brauch
    • , Hermann Brenner
    • , James D. Brenton
    • , Mark N. Brook
    • , Joan Brunet
    • , Hans Brunnström
    • , Daniel D. Buchanan
    • , Barbara Burwinkel
    • , Ralf Butzow
    • , Gabriella Cadoni
    • , Trinidad Caldés
    • , Maria A. Caligo
    • , Ian Campbell
    • , Peter T. Campbell
    • , Géraldine Cancel-Tassin
    • , Lisa Cannon-Albright
    • , Daniele Campa
    • , Neil Caporaso
    • , André L. Carvalho
    • , Andrew T. Chan
    • , Jenny Chang-Claude
    • , Stephen J. Chanock
    • , Chu Chen
    • , David C. Christiani
    • , Kathleen B. M. Claes
    • , Frank Claessens
    • , Judith Clements
    • , J. Margriet Collée
    • , Marcia Cruz Correa
    • , Fergus J. Couch
    • , Angela Cox
    • , Julie M. Cunningham
    • , Cezary Cybulski
    • , Kamila Czene
    • , Mary B. Daly
    • , Anna deFazio
    • , Peter Devilee
    • , Orland Diez
    • , Manuela Gago-Dominguez
    • , Jenny L. Donovan
    • , Thilo Dörk
    • , Eric J. Duell
    • , Alison M. Dunning
    • , Miriam Dwek
    • , Diana M. Eccles
    • , Christopher K. Edlund
    • , Digna R Velez Edwards
    • , Carolina Ellberg
    • , D. Gareth Evans
    • , Peter A. Fasching
    • , Robert L. Ferris
    • , Triantafillos Liloglou
    • , Jane C. Figueiredo
    • , Olivia Fletcher
    • , Renée T. Fortner
    • , Florentia Fostira
    • , Silvia Franceschi
    • , Eitan Friedman
    • , Steven J. Gallinger
    • , Patricia A. Ganz
    • , Judy Garber
    • , José A. García-Sáenz
    • , Simon A. Gayther
    • , Graham G. Giles
    • , Andrew K. Godwin
    • , Mark S. Goldberg
    • , David E. Goldgar
    • , Ellen L. Goode
    • , Marc T. Goodman
    • , Gary Goodman
    • , Kjell Grankvist
    • , Mark H. Greene
    • , Henrik Gronberg
    • , Jacek Gronwald
    • , Pascal Guénel
    • , Niclas Håkansson
    • , Per Hall
    • , Ute Hamann
    • , Freddie C. Hamdy
    • , Robert J. Hamilton
    • , Jochen Hampe
    • , Aage Haugen
    • , Florian Heitz
    • , Rolando Herrero
    • , Peter Hillemanns
    • , Michael Hoffmeister
    • , Estrid Høgdall
    • , Yun-Chul Hong
    • , John L. Hopper
    • , Richard Houlston
    • , Peter J. Hulick
    • , David J. Hunter
    • , David G. Huntsman
    • , Gregory Idos
    • , Evgeny N. Imyanitov
    • , Sue Ann Ingles
    • , Claudine Isaacs
    • , Anna Jakubowska
    • , Paul James
    • , Mark A. Jenkins
    • , Mattias Johansson
    • , Mikael Johansson
    • , Esther M. John
    • , Amit D. Joshi
    • , Radka Kaneva
    • , Beth Y. Karlan
    • , Linda E. Kelemen
    • , Tabea Kühl
    • , Kay-Tee Khaw
    • , Elza Khusnutdinova
    • , Adam S. Kibel
    • , Lambertus A. Kiemeney
    • , Jeri Kim
    • , Susanne K. Kjaer
    • , Julia A. Knight
    • , Manolis Kogevinas
    • , Zsofia Kote-Jarai
    • , Stella Koutros
    • , Vessela N. Kristensen
    • , Jolanta Kupryjanczyk
    • , Martin Lacko
    • , Stephan Lam
    • , Diether Lambrechts
    • , Maria Teresa Landi
    • , Philip Lazarus
    • , Nhu D. Le
    • , Eunjung Lee
    • , Flavio Lejbkowicz
    • , Heinz-Josef Lenz
    • , Goska Leslie
    • , Davor Lessel
    • , Jenny Lester
    • , Douglas A. Levine
    • , Li Li
    • , Christopher I. Li
    • , Annika Lindblom
    • , Noralane M. Lindor
    • , Geoffrey Liu
    • , Fotios Loupakis
    • , Jan Lubiński
    • , Lovise Maehle
    • , Christiane Maier
    • , Arto Mannermaa
    • , Loic Le Marchand
    • , Sara Margolin
    • , Taymaa May
    • , Lesley McGuffog
    • , Alfons Meindl
    • , Pooja Middha
    • , Austin Miller
    • , Roger L. Milne
    • , Robert J. MacInnis
    • , Francesmary Modugno
    • , Marco Montagna
    • , Victor Moreno
    • , Kirsten B. Moysich
    • , Lorelei Mucci
    • , Kenneth Muir
    • , Anna Marie Mulligan
    • , Katherine L. Nathanson
    • , David E. Neal
    • , Andrew R. Ness
    • , Susan L. Neuhausen
    • , Heli Nevanlinna
    • , Polly A. Newcomb
    • , Lisa F. Newcomb
    • , Finn Cilius Nielsen
    • , Liene Nikitina-Zake
    • , Børge G. Nordestgaard
    • , Robert L. Nussbaum
    • , Kenneth Offit
    • , Edith Olah
    • , Ali Amin Al Olama
    • , Olufunmilayo I. Olopade
    • , Andrew F. Olshan
    • , Håkan Olsson
    • , Ana Osorio
    • , Hardev Pandha
    • , Jong Y. Park
    • , Nora Pashayan
    • , Michael T. Parsons
    • , Tanja Pejovic
    • , Kathryn L. Penney
    • , Wilbert H M. Peters
    • , Catherine M. Phelan
    • , Amanda I. Phipps
    • , Dijana Plaseska-Karanfilska
    • , Miranda Pring
    • , Darya Prokofyeva
    • , Paolo Radice
    • , Kari Stefansson
    • , Susan J. Ramus
    • , Leon Raskin
    • , Gad Rennert
    • , Hedy S. Rennert
    • , Elizabeth J. van Rensburg
    • , Marjorie J. Riggan
    • , Harvey A. Risch
    • , Angela Risch
    • , Monique J. Roobol
    • , Barry S. Rosenstein
    • , Mary Anne Rossing
    • , Kim De Ruyck
    • , Emmanouil Saloustros
    • , Dale P. Sandler
    • , Elinor J. Sawyer
    • , Matthew B. Schabath
    • , Johanna Schleutker
    • , Marjanka K. Schmidt
    • , V. Wendy Setiawan
    • , Hongbing Shen
    • , Erin M. Siegel
    • , Weiva Sieh
    • , Christian F. Singer
    • , Martha L. Slattery
    • , Karina Dalsgaard Sorensen
    • , Melissa C. Southey
    • , Amanda B. Spurdle
    • , Janet L. Stanford
    • , Victoria L. Stevens
    • , Sebastian Stintzing
    • , Jennifer Stone
    • , Karin Sundfeldt
    • , Rebecca Sutphen
    • , Anthony J. Swerdlow
    • , Eloiza H. Tajara
    • , Catherine M. Tangen
    • , Adonina Tardon
    • , Jack A. Taylor
    • , M. Dawn Teare
    • , Manuel R. Teixeira
    • , Mary Beth Terry
    • , Kathryn L. Terry
    • , Stephen N. Thibodeau
    • , Mads Thomassen
    • , Line Bjørge
    • , Marc Tischkowitz
    • , Amanda E. Toland
    • , Diana Torres
    • , Paul A. Townsend
    • , Ruth C. Travis
    • , Nadine Tung
    • , Shelley S. Tworoger
    • , Cornelia M. Ulrich
    • , Nawaid Usmani
    • , Celine M. Vachon
    • , Els Van Nieuwenhuysen
    • , Ana Vega
    • , Miguel Elías Aguado-Barrera
    • , Qin Wang
    • , Penelope M. Webb
    • , Clarice R. Weinberg
    • , Stephanie Weinstein
    • , Mark C. Weissler
    • , Jeffrey N. Weitzel
    • , Catharine M. L. West
    • , Emily White
    • , Alice S. Whittemore
    • , H-Erich Wichmann
    • , Fredrik Wiklund
    • , Robert Winqvist
    • , Alicja Wolk
    • , Penella Woll
    • , Michael Woods
    • , Anna H. Wu
    • , Xifeng Wu
    • , Drakoulis Yannoukakos
    • , Wei Zheng
    • , Shanbeh Zienolddiny
    • , Argyrios Ziogas
    • , Kristin K. Zorn
    • , Jacqueline M. Lane
    • , Richa Saxena
    • , Duncan Thomas
    • , Rayjean J. Hung
    • , Brenda Diergaarde
    • , James McKay
    • , Ulrike Peters
    • , Li Hsu
    • , Montserrat García-Closas
    • , Rosalind A. Eeles
    • , Georgia Chenevix-Trench
    • , Paul J. Brennan
    • , Christopher A. Haiman
    • , Jacques Simard
    • , Douglas F. Easton
    • , Stephen B. Gruber
    • , Paul D. P. Pharoah
    • , Alkes L. Price
    • , Bogdan Pasaniuc
    • , Christopher I. Amos
    • , Peter Kraft
    •  & Sara Lindström
  • Article | | open

    Some perinatally HIV infected children who have received early antiretroviral therapy (ART) show long-term sustained virological control after ART cessation. Here the authors describe a case who, at age 9.5 years, shows normal CD4:CD8 T cell ratios and has no detectable levels of replication-competent virus.

    • Avy Violari
    • , Mark F. Cotton
    • , Louise Kuhn
    • , Diana B. Schramm
    • , Maria Paximadis
    • , Shayne Loubser
    • , Sharon Shalekoff
    • , Bianca Da Costa Dias
    • , Kennedy Otwombe
    • , Afaaf Liberty
    • , James McIntyre
    • , Abdel Babiker
    • , Diana Gibb
    •  & Caroline T. Tiemessen
  • Article | | open

    Population structure can bias the results of genetic and epidemiological analysis. Here, Haworth et al. report that fine-scale structure is detectable in apparently homogeneous samples such as ALSPAC when measured very precisely, and remains detectable in UK Biobank despite conventional approaches to account for it.

    • Simon Haworth
    • , Ruth Mitchell
    • , Laura Corbin
    • , Kaitlin H. Wade
    • , Tom Dudding
    • , Ashley Budu-Aggrey
    • , David Carslake
    • , Gibran Hemani
    • , Lavinia Paternoster
    • , George Davey Smith
    • , Neil Davies
    • , Daniel J. Lawson
    •  & Nicholas J. Timpson
  • Article | | open

    FLT3 is commonly mutated in acute myeloid leukaemia and treatment with FLT3 inhibitors often ends with relapse. Here, the authors perform exome sequencing of samples from patients treated with the FLT3 inhibitor, crenolanib, to show that resistance occurs due to diverse molecular mechanisms, not primarily due to secondary FLT3 mutations.

    • Haijiao Zhang
    • , Samantha Savage
    • , Anna Reister Schultz
    • , Daniel Bottomly
    • , Libbey White
    • , Erik Segerdell
    • , Beth Wilmot
    • , Shannon K. McWeeney
    • , Christopher A. Eide
    • , Tamilla Nechiporuk
    • , Amy Carlos
    • , Rachel Henson
    • , Chenwei Lin
    • , Robert Searles
    • , Hoang Ho
    • , Yee Ling Lam
    • , Richard Sweat
    • , Courtney Follit
    • , Vinay Jain
    • , Evan Lind
    • , Gautam Borthakur
    • , Guillermo Garcia-Manero
    • , Farhad Ravandi
    • , Hagop M. Kantarjian
    • , Jorge Cortes
    • , Robert Collins
    • , Daelynn R. Buelow
    • , Sharyn D. Baker
    • , Brian J. Druker
    •  & Jeffrey W. Tyner
  • Article | | open

    Real-time disease surveillance can aid mitigation of outbreaks. Here, Lu et al. combine an approach using Google search and EHR data with an approach leveraging spatiotemporal synchronicities of influenza activity across states to improve state-level influenza activity estimates in the US.

    • Fred S. Lu
    • , Mohammad W. Hattab
    • , Cesar Leonardo Clemente
    • , Matthew Biggerstaff
    •  & Mauricio Santillana
  • Article | | open

    Relevance of indirect protection of household members of vaccinees is unclear. Here, Tsang et al. quantify the direct and indirect protection of vaccination in a randomized controlled trial and show that benefits of individual vaccination remain important even when other household members are vaccinated.

    • Tim K. Tsang
    • , Vicky J. Fang
    • , Dennis K. M. Ip
    • , Ranawaka A. P. M. Perera
    • , Hau Chi So
    • , Gabriel M. Leung
    • , J. S. Malik Peiris
    • , Benjamin J. Cowling
    •  & Simon Cauchemez
  • Article | | open

    While human lifespan is only moderately heritable, “getting old” runs in families. Here, van den Berg et al. study mortality data from three-generation cohorts to define a threshold for longevity and find that individuals have an increasing survival advantage with each additional relative in the top 10% survivors of their birth cohort.

    • Niels van den Berg
    • , Mar Rodríguez-Girondo
    • , Ingrid K. van Dijk
    • , Rick J. Mourits
    • , Kees Mandemakers
    • , Angelique A. P. O. Janssens
    • , Marian Beekman
    • , Ken R. Smith
    •  & P. Eline Slagboom
  • Article | | open

    Robust surveillance methods are needed for trachoma control and recrudescence monitoring, but existing methods have limitations. Here, Pinsent et al. analyse data from nine trachoma-endemic populations and provide operational thresholds for interpretation of serological data in low transmission and post-elimination settings.

    • Amy Pinsent
    • , Anthony W. Solomon
    • , Robin L. Bailey
    • , Rhiannon Bid
    • , Anaseini Cama
    • , Deborah Dean
    • , Brook Goodhew
    • , Sarah E. Gwyn
    • , Kelvin R. Jack
    • , Ram Prasad Kandel
    • , Mike Kama
    • , Patrick Massae
    • , Colin Macleod
    • , David C. W. Mabey
    • , Stephanie Migchelsen
    • , Andreas Müller
    • , Frank Sandi
    • , Oliver Sokana
    • , Raebwebwe Taoaba
    • , Rabebe Tekeraoi
    • , Diana L. Martin
    •  & Michael. T. White
  • Article | | open

    In gene regulation, diversification at the transcriptome 3′end is linked to differentiation and dedifferentiation. Here, the authors discover extensive transcriptome 3′end-alterations in neuroblastoma, regulated by PCF11, and provide an interactive data repository of transcriptome-wide alternative polyadenylation.

    • Anton Ogorodnikov
    • , Michal Levin
    • , Surendra Tattikota
    • , Sergey Tokalov
    • , Mainul Hoque
    • , Denise Scherzinger
    • , Federico Marini
    • , Ansgar Poetsch
    • , Harald Binder
    • , Stephan Macher-Göppinger
    • , Hans Christian Probst
    • , Bin Tian
    • , Michael Schaefer
    • , Karl J. Lackner
    • , Frank Westermann
    •  & Sven Danckwardt
  • Article | | open

    Nutritional experience can have phenotypic consequences in subsequent generations, as is evident from studies in animals and plants. Here, Vågerö et al. find in a large three-generation cohort that access to food in the paternal grandfather associates with all-cause and cancer mortality in male grandchildren.

    • Denny Vågerö
    • , Pia R. Pinger
    • , Vanda Aronsson
    •  & Gerard J. van den Berg
  • Article | | open

    Studying the genetic underpinnings of physical activity and sleep duration can be confounded by self-reporting. Here, Doherty et al. use data from 91,105 UK Biobank participants, whose activity had been monitored for a week by a wearable device, for genome-wide association analysis and identify 14 loci.

    • Aiden Doherty
    • , Karl Smith-Byrne
    • , Teresa Ferreira
    • , Michael V. Holmes
    • , Chris Holmes
    • , Sara L. Pulit
    •  & Cecilia M. Lindgren
  • Article | | open

    Epilepsies are common brain disorders and are classified based on clinical phenotyping, imaging and genetics. Here, the authors perform genome-wide association studies for 3 broad and 7 subtypes of epilepsy and identify 16 loci - 11 novel - that are further annotated by eQTL and partitioned heritability analyses.

    • Bassel Abou-Khalil
    • , Pauls Auce
    • , Andreja Avbersek
    • , Melanie Bahlo
    • , David J. Balding
    • , Thomas Bast
    • , Larry Baum
    • , Albert J. Becker
    • , Felicitas Becker
    • , Bianca Berghuis
    • , Samuel F. Berkovic
    • , Katja E. Boysen
    • , Jonathan P. Bradfield
    • , Lawrence C. Brody
    • , Russell J. Buono
    • , Ellen Campbell
    • , Gregory D. Cascino
    • , Claudia B. Catarino
    • , Gianpiero L. Cavalleri
    • , Stacey S. Cherny
    • , Krishna Chinthapalli
    • , Alison J. Coffey
    • , Alastair Compston
    • , Antonietta Coppola
    • , Patrick Cossette
    • , John J. Craig
    • , Gerrit-Jan de Haan
    • , Peter De Jonghe
    • , Carolien G. F. de Kovel
    • , Norman Delanty
    • , Chantal Depondt
    • , Orrin Devinsky
    • , Dennis J. Dlugos
    • , Colin P. Doherty
    • , Christian E. Elger
    • , Johan G. Eriksson
    • , Thomas N. Ferraro
    • , Martha Feucht
    • , Ben Francis
    • , Andre Franke
    • , Jacqueline A. French
    • , Saskia Freytag
    • , Verena Gaus
    • , Eric B. Geller
    • , Christian Gieger
    • , Tracy Glauser
    • , Simon Glynn
    • , David B. Goldstein
    • , Hongsheng Gui
    • , Youling Guo
    • , Kevin F. Haas
    • , Hakon Hakonarson
    • , Kerstin Hallmann
    • , Sheryl Haut
    • , Erin L. Heinzen
    • , Ingo Helbig
    • , Christian Hengsbach
    • , Helle Hjalgrim
    • , Michele Iacomino
    • , Andrés Ingason
    • , Jennifer Jamnadas-Khoda
    • , Michael R. Johnson
    • , Reetta Kälviäinen
    • , Anne-Mari Kantanen
    • , Dalia Kasperavičiūte
    • , Dorothee Kasteleijn-Nolst Trenite
    • , Heidi E. Kirsch
    • , Robert C. Knowlton
    • , Bobby P. C. Koeleman
    • , Roland Krause
    • , Martin Krenn
    • , Wolfram S. Kunz
    • , Ruben Kuzniecky
    • , Patrick Kwan
    • , Dennis Lal
    • , Yu-Lung Lau
    • , Anna-Elina Lehesjoki
    • , Holger Lerche
    • , Costin Leu
    • , Wolfgang Lieb
    • , Dick Lindhout
    • , Warren D. Lo
    • , Iscia Lopes-Cendes
    • , Daniel H. Lowenstein
    • , Alberto Malovini
    • , Anthony G. Marson
    • , Thomas Mayer
    • , Mark McCormack
    • , James L. Mills
    • , Nasir Mirza
    • , Martina Moerzinger
    • , Rikke S. Møller
    • , Anne M. Molloy
    • , Hiltrud Muhle
    • , Mark Newton
    • , Ping-Wing Ng
    • , Markus M. Nöthen
    • , Peter Nürnberg
    • , Terence J. O’Brien
    • , Karen L. Oliver
    • , Aarno Palotie
    • , Faith Pangilinan
    • , Sarah Peter
    • , Slavé Petrovski
    • , Annapurna Poduri
    • , Michael Privitera
    • , Rodney Radtke
    • , Sarah Rau
    • , Philipp S. Reif
    • , Eva M. Reinthaler
    • , Felix Rosenow
    • , Josemir W. Sander
    • , Thomas Sander
    • , Theresa Scattergood
    • , Steven C. Schachter
    • , Christoph J. Schankin
    • , Ingrid E. Scheffer
    • , Bettina Schmitz
    • , Susanne Schoch
    • , Pak C. Sham
    • , Jerry J. Shih
    • , Graeme J. Sills
    • , Sanjay M. Sisodiya
    • , Lisa Slattery
    • , Alexander Smith
    • , David F. Smith
    • , Michael C. Smith
    • , Philip E. Smith
    • , Anja C. M. Sonsma
    • , Doug Speed
    • , Michael R. Sperling
    • , Bernhard J. Steinhoff
    • , Ulrich Stephani
    • , Remi Stevelink
    • , Konstantin Strauch
    • , Pasquale Striano
    • , Hans Stroink
    • , Rainer Surges
    • , K. Meng Tan
    • , Liu Lin Thio
    • , G. Neil Thomas
    • , Marian Todaro
    • , Rossana Tozzi
    • , Maria S. Vari
    • , Eileen P. G. Vining
    • , Frank Visscher
    • , Sarah von Spiczak
    • , Nicole M. Walley
    • , Yvonne G. Weber
    • , Zhi Wei
    • , Judith Weisenberg
    • , Christopher D. Whelan
    • , Peter Widdess-Walsh
    • , Markus Wolff
    • , Stefan Wolking
    • , Wanling Yang
    • , Federico Zara
    •  & Fritz Zimprich
  • Article | | open

    Brain–machine interfaces typically decode arm velocity from motor cortical neurons to move neuroprostheses, but performance of these devices is degraded by erroneous extraction of speed from the neuronal firing patterns. Here, the authors show that this error can be corrected by using a hybrid artificial neural network approach.

    • Yoh Inoue
    • , Hongwei Mao
    • , Steven B. Suway
    • , Josue Orellana
    •  & Andrew B. Schwartz
  • Article | | open

    The tuberculosis pandemic requires new methods for diagnosing and containing infections prior to active disease. Here, the authors performed a multi-site observational study within sub-Saharan Africa and present serum and plasma metabolic signatures that can predict the onset of active TB with a high degree of sensitivity and specificity.

    • January Weiner 3rd
    • , Jeroen Maertzdorf
    • , Jayne S. Sutherland
    • , Fergal J. Duffy
    • , Ethan Thompson
    • , Sara Suliman
    • , Gayle McEwen
    • , Bonnie Thiel
    • , Shreemanta K. Parida
    • , Joanna Zyla
    • , Willem A. Hanekom
    • , Robert P. Mohney
    • , W. Henry Boom
    • , Harriet Mayanja-Kizza
    • , Rawleigh Howe
    • , Hazel M. Dockrell
    • , Tom H. M. Ottenhoff
    • , Thomas J. Scriba
    • , Daniel E. Zak
    • , Gerhard Walzl
    • , Stefan H. E. Kaufmann
    • , Almaz Abebe
    • , Brian Abel
    • , Richard Adegbola
    • , Ifedayo Adetifa
    • , Lyn Ambrose
    • , Peter Andersen
    • , Martin Antonio
    • , Abraham Aseffa
    • , Debbie van Baarle
    • , Lew Barker
    • , Yonas Bekele
    • , Nicole Bilek
    • , Gillian F. Black
    • , Mark Bowmaker
    • , Keith Branson
    • , Michael Brennan
    • , Novel N. Chegou
    • , Femia Chilongo
    • , William Kwong Chung
    • , Tumani Corrah
    • , Ameilia C. Crampin
    • , Mark Doherty
    • , Gregory Dolganov
    • , Simon Donkor
    • , Katrina Downing
    • , Michelle Fisher
    • , Kees L. M. C. Franken
    • , Neil French
    • , Larry Geiter
    • , Annemieke Geluk
    • , Robert Golinski
    • , Patricia Gorak-Stolinska
    • , Marielle C. Haks
    • , Philip Hill
    • , Jane Hughes
    • , Yun-Gyoung Hur
    • , Rachel Iwnetu
    • , Marc Jacobson
    • , Moses Joloba
    • , Simone A. Joosten
    • , Benjamin Kagina
    • , Desta Kassa
    • , Hussein Kisingo
    • , Michel R. Klein
    • , Magdalena Kriel
    • , Maeve Lalor
    • , Ji-Sook Lee
    • , Andre G. Loxton
    • , Hassan Mahomed
    • , Krista E. van Meijgaarden
    • , Tsehayenesh Mesele
    • , Frank Miedema
    • , Adane Mihret
    • , Humphrey Mulenga
    • , Stefanie Muller
    • , Hazzie Mvula
    • , Nonhlanhla Nene
    • , Bagrey Ngwira
    • , Mary Nsereko
    • , Brenda Okwera
    • , Martin Ota
    • , Adam Penn-Nicholson
    • , Nelita Du Plessis
    • , S. Ramachandran
    • , Ida Rosenkrands
    • , Jerry Sadoff
    • , Jacky Saul
    • , Gary Schoolnik
    • , Felanji Simukonda
    • , Donata Sizemore
    • , Steven Smith
    • , Anne Ben Smith
    • , Gian van der Spuy
    • , Kim Stanley
    • , David Tabb
    • , Mesfin Tafesse
    • , Belete Tegbaru
    • , Toyin Togun
    • , Gerhardus Tromp
    • , Tran Van
    • , Kate Watkins
    • , Frank Weichold
    • , Karin Weldingh
    • , Lawrence Yamuah
    •  & Sarah Zalwango
  • Article | | open

    Biomedical image analysis challenges have increased in the last ten years, but common practices have not been established yet. Here the authors analyze 150 recent challenges and demonstrate that outcome varies based on the metrics used and that limited information reporting hampers reproducibility.

    • Lena Maier-Hein
    • , Matthias Eisenmann
    • , Annika Reinke
    • , Sinan Onogur
    • , Marko Stankovic
    • , Patrick Scholz
    • , Tal Arbel
    • , Hrvoje Bogunovic
    • , Andrew P. Bradley
    • , Aaron Carass
    • , Carolin Feldmann
    • , Alejandro F. Frangi
    • , Peter M. Full
    • , Bram van Ginneken
    • , Allan Hanbury
    • , Katrin Honauer
    • , Michal Kozubek
    • , Bennett A. Landman
    • , Keno März
    • , Oskar Maier
    • , Klaus Maier-Hein
    • , Bjoern H. Menze
    • , Henning Müller
    • , Peter F. Neher
    • , Wiro Niessen
    • , Nasir Rajpoot
    • , Gregory C. Sharp
    • , Korsuk Sirinukunwattana
    • , Stefanie Speidel
    • , Christian Stock
    • , Danail Stoyanov
    • , Abdel Aziz Taha
    • , Fons van der Sommen
    • , Ching-Wei Wang
    • , Marc-André Weber
    • , Guoyan Zheng
    • , Pierre Jannin
    •  & Annette Kopp-Schneider
  • Article | | open

    Autoantibodies are implicated in autoimmunity, but may also be present in healthy individuals. Here the authors find that the autoantibody specificity signatures against various G protein-coupled receptors are associated with multiple parameters, including disease states, to imply a physiological function in maintaining immune homeostasis.

    • Otavio Cabral-Marques
    • , Alexandre Marques
    • , Lasse Melvær Giil
    • , Roberta De Vito
    • , Judith Rademacher
    • , Jeannine Günther
    • , Tanja Lange
    • , Jens Y. Humrich
    • , Sebastian Klapa
    • , Susanne Schinke
    • , Lena F. Schimke
    • , Gabriele Marschner
    • , Silke Pitann
    • , Sabine Adler
    • , Ralf Dechend
    • , Dominik N. Müller
    • , Ioana Braicu
    • , Jalid Sehouli
    • , Kai Schulze-Forster
    • , Tobias Trippel
    • , Carmen Scheibenbogen
    • , Annetine Staff
    • , Peter R. Mertens
    • , Madlen Löbel
    • , Justin Mastroianni
    • , Corinna Plattfaut
    • , Frank Gieseler
    • , Duska Dragun
    • , Barbara Elizabeth Engelhardt
    • , Maria J. Fernandez-Cabezudo
    • , Hans D. Ochs
    • , Basel K. al-Ramadi
    • , Peter Lamprecht
    • , Antje Mueller
    • , Harald Heidecke
    •  & Gabriela Riemekasten
  • Article | | open

    The rate of repair declines with age; however, exposure to young circulations can rejuvenate fracture repair, but how this is accomplished is unknown. Here, the authors identify proteins, including low-density lipoprotein receptor-related protein 1 (Lrp1), as being secreted from young macrophages and rejuvenating fracture repair in mice.

    • Linda Vi
    • , Gurpreet S. Baht
    • , Erik J. Soderblom
    • , Heather Whetstone
    • , Qingxia Wei
    • , Bridgette Furman
    • , Vijitha Puviindran
    • , Puviindran Nadesan
    • , Matthew Foster
    • , Raymond Poon
    • , James P. White
    • , Yasuhito Yahara
    • , Adeline Ng
    • , Tomasa Barrientos
    • , Marc Grynpas
    • , M. Arthur Mosely
    •  & Benjamin A. Alman
  • Article | | open

    Multimorbidities of common diseases often have shared underlying predisposing factors. Here Fadason et al. study the pleiotropy of SNPs and their effects on target genes by integrating chromatin interaction and expression quantitative trait loci data to identify target genes shared between phenotypes.

    • Tayaza Fadason
    • , William Schierding
    • , Thomas Lumley
    •  & Justin M. O’Sullivan
  • Article | | open

    DNA methylation is an epigenetic modification that control genetic programs. Here, the authors found that the methylation landscape influences the physicochemical properties of DNA and that it can serve as a universal cancer biomarker, and developed a one-step assay for the detection of cancer DNA.

    • Abu Ali Ibn Sina
    • , Laura G. Carrascosa
    • , Ziyu Liang
    • , Yadveer S. Grewal
    • , Andri Wardiana
    • , Muhammad J. A. Shiddiky
    • , Robert A. Gardiner
    • , Hemamali Samaratunga
    • , Maher K. Gandhi
    • , Rodney J. Scott
    • , Darren Korbie
    •  & Matt Trau
  • Article | | open

    Typhoid fever is caused by the bacterium Salmonella Typhi. Here, Park et al. analyse the genomes of 249 S. Typhi isolates from 11 sub-Saharan African countries, identifying genes and plasmids associated with antibiotic resistance and showing that multi-drug resistance is highly pervasive in sub-Saharan Africa.

    • Se Eun Park
    • , Duy Thanh Pham
    • , Christine Boinett
    • , Vanessa K. Wong
    • , Gi Deok Pak
    • , Ursula Panzner
    • , Ligia Maria Cruz Espinoza
    • , Vera von Kalckreuth
    • , Justin Im
    • , Heidi Schütt-Gerowitt
    • , John A. Crump
    • , Robert F. Breiman
    • , Yaw Adu-Sarkodie
    • , Ellis Owusu-Dabo
    • , Raphaël Rakotozandrindrainy
    • , Abdramane Bassiahi Soura
    • , Abraham Aseffa
    • , Nagla Gasmelseed
    • , Karen H. Keddy
    • , Jürgen May
    • , Amy Gassama Sow
    • , Peter Aaby
    • , Holly M. Biggs
    • , Julian T. Hertz
    • , Joel M. Montgomery
    • , Leonard Cosmas
    • , Beatrice Olack
    • , Barry Fields
    • , Nimako Sarpong
    • , Tsiriniaina Jean Luco Razafindrabe
    • , Tiana Mirana Raminosoa
    • , Leon Parfait Kabore
    • , Emmanuel Sampo
    • , Mekonnen Teferi
    • , Biruk Yeshitela
    • , Muna Ahmed El Tayeb
    • , Arvinda Sooka
    • , Christian G. Meyer
    • , Ralf Krumkamp
    • , Denise Myriam Dekker
    • , Anna Jaeger
    • , Sven Poppert
    • , Adama Tall
    • , Aissatou Niang
    • , Morten Bjerregaard-Andersen
    • , Sandra Valborg Løfberg
    • , Hye Jin Seo
    • , Hyon Jin Jeon
    • , Jessica Fung Deerin
    • , Jinkyung Park
    • , Frank Konings
    • , Mohammad Ali
    • , John D. Clemens
    • , Peter Hughes
    • , Juliet Nsimire Sendagala
    • , Tobias Vudriko
    • , Robert Downing
    • , Usman N. Ikumapayi
    • , Grant A. Mackenzie
    • , Stephen Obaro
    • , Silvia Argimon
    • , David M. Aanensen
    • , Andrew Page
    • , Jacqueline A. Keane
    • , Sebastian Duchene
    • , Zoe Dyson
    • , Kathryn E. Holt
    • , Gordon Dougan
    • , Florian Marks
    •  & Stephen Baker
  • Article | | open

    Neutrophil extracellular traps (NETs) are known to promote metastasis in mouse models. Here the authors show plasma redox imbalance caused by albumin oxidation to induce inflammation-independent NETosis and lung metastasis, and albumin oxidation and reduced plasma free thiol to be associated with lung metastasis in a cohort of head and neck cancer patients.

    • Minoru Inoue
    • , Ryota Nakashima
    • , Masahiro Enomoto
    • , Yuhki Koike
    • , Xiao Zhao
    • , Kenneth Yip
    • , Shao Hui Huang
    • , John N. Waldron
    • , Mitsuhiko Ikura
    • , Fei-Fei Liu
    •  & Scott V. Bratman
  • Article | | open

    Antifungal resistance due to upregulation of efflux pumps is common in Candida albicans. Here, the authors show that conjugation with mitochondria-targeting triphenylphosphonium cation can enhance or restore the antifungal activity of potential efflux pump substrates.

    • Wenqiang Chang
    • , Jun Liu
    • , Ming Zhang
    • , Hongzhuo Shi
    • , Sha Zheng
    • , Xueyang Jin
    • , Yanhui Gao
    • , Shuqi Wang
    • , Aiguo Ji
    •  & Hongxiang Lou
  • Article | | open

    The methylation status of circulating cell-free DNA (cfDNA) can be informative about recent cell death events. Here the authors present an approach to determine the tissue origins of cfDNA, using a reference methylation atlas of 25 human tissues and cell types, and find that cfDNA from patients reveals tissue contributions that agree with clinical findings.

    • Joshua Moss
    • , Judith Magenheim
    • , Daniel Neiman
    • , Hai Zemmour
    • , Netanel Loyfer
    • , Amit Korach
    • , Yaacov Samet
    • , Myriam Maoz
    • , Henrik Druid
    • , Peter Arner
    • , Keng-Yeh Fu
    • , Endre Kiss
    • , Kirsty L. Spalding
    • , Giora Landesberg
    • , Aviad Zick
    • , Albert Grinshpun
    • , A. M. James Shapiro
    • , Markus Grompe
    • , Avigail Dreazan Wittenberg
    • , Benjamin Glaser
    • , Ruth Shemer
    • , Tommy Kaplan
    •  & Yuval Dor
  • Article | | open

    Intervertebral disk degeneration (IDD) is characterized by changes in the nucleus pulposus (NP) extra cellular matrix that compromise disk structural integrity. In a miRNA screen of human IDD patient NP tissue, the authors identify deregulated miR-141 and show that direct injection of nanoparticle-coupled miR-141 into the NP alleviates IDD in mice.

    • Ming-liang Ji
    • , Hua Jiang
    • , Xue-jun Zhang
    • , Pei-liang Shi
    • , Chao Li
    • , Hao Wu
    • , Xiao-tao Wu
    • , Yun-tao Wang
    • , Chen Wang
    •  & Jun Lu
  • Article | | open

    Indoor residual spraying is a commonly used method for mosquito, and malaria, control and there are a number of available insecticides that are available for this. Here, the authors evaluate the efficacy of widely-used and novel insecticides against pyrethroid-resistant mosquitoes.

    • Ellie Sherrard-Smith
    • , Jamie T. Griffin
    • , Peter Winskill
    • , Vincent Corbel
    • , Cédric Pennetier
    • , Armel Djénontin
    • , Sarah Moore
    • , Jason H. Richardson
    • , Pie Müller
    • , Constant Edi
    • , Natacha Protopopoff
    • , Richard Oxborough
    • , Fiacre Agossa
    • , Raphael N’Guessan
    • , Mark Rowland
    •  & Thomas S. Churcher
  • Article | | open

    Treatment-seeking for fever is widely used to estimate treatment of childhood infections, but cross-country comparisons are problematic. Here, the authors estimate the probability of seeking treatment for fever at public facilities across 29 countries by quantifying person-level latent variables.

    • Victor A. Alegana
    • , Joseph Maina
    • , Paul O. Ouma
    • , Peter M. Macharia
    • , Jim Wright
    • , Peter M. Atkinson
    • , Emelda A. Okiro
    • , Robert W. Snow
    •  & Andrew J. Tatem
  • Article | | open

    The molecular mechanisms that underlie associations in GWAS, incl. chronic kidney disease (CKD), are largely unknown. Here, the authors perform an integrative analysis of genetic, transcriptomic and epigenomic data from human kidney to pinpoint plausible molecular pathways of CKD genetic associations.

    • Xiaoguang Xu
    • , James M. Eales
    • , Artur Akbarov
    • , Hui Guo
    • , Lorenz Becker
    • , David Talavera
    • , Fehzan Ashraf
    • , Jabran Nawaz
    • , Sanjeev Pramanik
    • , John Bowes
    • , Xiao Jiang
    • , John Dormer
    • , Matthew Denniff
    • , Andrzej Antczak
    • , Monika Szulinska
    • , Ingrid Wise
    • , Priscilla R. Prestes
    • , Maciej Glyda
    • , Pawel Bogdanski
    • , Ewa Zukowska-Szczechowska
    • , Carlo Berzuini
    • , Adrian S. Woolf
    • , Nilesh J. Samani
    • , Fadi J. Charchar
    •  & Maciej Tomaszewski
  • Article | | open

    Hepatitis E virus (HEV) infection can result in severe placental disease, but mechanisms underlying pathogenicity are poorly understood. Here, the authors develop an ex vivo model for HEV infection at the maternal-fetal interface and compare pathogenicity of different HEV genotypes.

    • Jordi Gouilly
    • , Qian Chen
    • , Johan Siewiera
    • , Géraldine Cartron
    • , Claude Levy
    • , Martine Dubois
    • , Reem Al-Daccak
    • , Jacques Izopet
    • , Nabila Jabrane-Ferrat
    •  & Hicham El Costa
  • Article | | open

    Accurate and actionable biomarkers that integrate diverse molecular, functional and clinical information hold great promise in precision medicine. Here, the authors develop SIMMS, a method for pathway-based cross-disease biomarker discovery.

    • Syed Haider
    • , Cindy Q. Yao
    • , Vicky S. Sabine
    • , Michal Grzadkowski
    • , Vincent Stimper
    • , Maud H. W. Starmans
    • , Jianxin Wang
    • , Francis Nguyen
    • , Nathalie C. Moon
    • , Xihui Lin
    • , Camilla Drake
    • , Cheryl A. Crozier
    • , Cassandra L. Brookes
    • , Cornelis J. H. van de Velde
    • , Annette Hasenburg
    • , Dirk G. Kieback
    • , Christos J. Markopoulos
    • , Luc Y. Dirix
    • , Caroline Seynaeve
    • , Daniel W. Rea
    • , Arek Kasprzyk
    • , Philippe Lambin
    • , Pietro Lio’
    • , John M. S. Bartlett
    •  & Paul C. Boutros
  • Article | | open

    The treatment of brain metastases is often limited by the ability to diagnose their origins. Here the authors generate DNA methylomes from the three most frequent types of brain metastases, identify epigenetic signatures specific to each type of metastasis and construct a DNA methylation-based classifier (BrainMETH) to advance brain metastasis diagnosis.

    • Javier I. J. Orozco
    • , Theo A. Knijnenburg
    • , Ayla O. Manughian-Peter
    • , Matthew P. Salomon
    • , Garni Barkhoudarian
    • , John R. Jalas
    • , James S. Wilmott
    • , Parvinder Hothi
    • , Xiaowen Wang
    • , Yuki Takasumi
    • , Michael E. Buckland
    • , John F. Thompson
    • , Georgina V. Long
    • , Charles S. Cobbs
    • , Ilya Shmulevich
    • , Daniel F. Kelly
    • , Richard A. Scolyer
    • , Dave S. B. Hoon
    •  & Diego M. Marzese
  • Article | | open

    Diagnostic tests need optimization to avoid invasive and costly repeated biopsies. Here the authors present an antibody-DNA barcoding approach where harvested single cells can be re-stained through custom oligonucleotide-fluorophore conjugates, enabling multiplexed analysis of cancer pathways.

    • Randy J. Giedt
    • , Divya Pathania
    • , Jonathan C. T. Carlson
    • , Philip J. McFarland
    • , Andres Fernandez del Castillo
    • , Dejan Juric
    •  & Ralph Weissleder
  • Article | | open

    In vitro expansion of human epidermal keratinocytes to resurface severe wound defects still relies on a human/mouse xenograft culture system. Here the authors develop a fully human, xeno-free culture system using skin-associated laminins, normally present in vivo, to replace mouse feeder cells.

    • Monica Suryana Tjin
    • , Alvin Wen Choong Chua
    • , Aida Moreno-Moral
    • , Li Yen Chong
    • , Po Yin Tang
    • , Nathan Peter Harmston
    • , Zuhua Cai
    • , Enrico Petretto
    • , Bien Keem Tan
    •  & Karl Tryggvason
  • Article | | open

    FISH-based techniques to image and count mRNA in single cells can be limited by the photophysical properties of organic dyes. Here the authors develop photostable quantum dot FISH probes for multiplexed imaging.

    • Yang Liu
    • , Phuong Le
    • , Sung Jun Lim
    • , Liang Ma
    • , Suresh Sarkar
    • , Zhiyuan Han
    • , Stephen J. Murphy
    • , Farhad Kosari
    • , George Vasmatzis
    • , John C. Cheville
    •  & Andrew M. Smith
  • Article | | open

    The response to respiratory virus exposure can currently not be predicted by pre- or early post-exposure molecular signatures. Here, the authors conduct a community-based analysis of blood gene expression from healthy individuals exposed to respiratory viruses and provide predictive models and biological insight into the physiological response.

    • Slim Fourati
    • , Aarthi Talla
    • , Mehrad Mahmoudian
    • , Joshua G. Burkhart
    • , Riku Klén
    • , Ricardo Henao
    • , Thomas Yu
    • , Zafer Aydın
    • , Ka Yee Yeung
    • , Mehmet Eren Ahsen
    • , Reem Almugbel
    • , Samad Jahandideh
    • , Xiao Liang
    • , Torbjörn E. M. Nordling
    • , Motoki Shiga
    • , Ana Stanescu
    • , Robert Vogel
    • , Emna Ben Abdallah
    • , Farnoosh Abbas Aghababazadeh
    • , Alicia Amadoz
    • , Sherry Bhalla
    • , Kevin Bleakley
    • , Erika Bongen
    • , Domenico Borzacchielo
    • , Philipp Bucher
    • , Jose Carbonell-Caballero
    • , Kumardeep Chaudhary
    • , Francisco Chinesta
    • , Prasad Chodavarapu
    • , Ryan D Chow
    • , Thomas Cokelaer
    • , Cankut Cubuk
    • , Sandeep Kumar Dhanda
    • , Joaquin Dopazo
    • , Thomas Faux
    • , Yang Feng
    • , Christofer Flinta
    • , Carito Guziolowski
    • , Di He
    • , Marta R. Hidalgo
    • , Jiayi Hou
    • , Katsumi Inoue
    • , Maria K Jaakkola
    • , Jiadong Ji
    • , Ritesh Kumar
    • , Sunil Kumar
    • , Miron Bartosz Kursa
    • , Qian Li
    • , Michał Łopuszyński
    • , Pengcheng Lu
    • , Morgan Magnin
    • , Weiguang Mao
    • , Bertrand Miannay
    • , Iryna Nikolayeva
    • , Zoran Obradovic
    • , Chi Pak
    • , Mohammad M. Rahman
    • , Misbah Razzaq
    • , Tony Ribeiro
    • , Olivier Roux
    • , Ehsan Saghapour
    • , Harsh Saini
    • , Shamim Sarhadi
    • , Hiroki Sato
    • , Benno Schwikowski
    • , Alok Sharma
    • , Ronesh Sharma
    • , Deepak Singla
    • , Ivan Stojkovic
    • , Tomi Suomi
    • , Maria Suprun
    • , Chengzhe Tian
    • , Lewis E. Tomalin
    • , Lei Xie
    • , Xiang Yu
    • , Gaurav Pandey
    • , Christopher Chiu
    • , Micah T. McClain
    • , Christopher W. Woods
    • , Geoffrey S. Ginsburg
    • , Laura L. Elo
    • , Ephraim L. Tsalik
    • , Lara M. Mangravite
    •  & Solveig K. Sieberts
  • Article | | open

    Small molecules and peptide inhibitors have their benefits and faults when it comes to inhibiting protein-protein interactions. Here, the authors designed a peptoid-peptide hybrid that inhibited β-catenin/TCF interactions, leading to inhibition of Wnt signalling in models of prostate cancer.

    • Jeffrey A. Schneider
    • , Timothy W. Craven
    • , Amanda C. Kasper
    • , Chi Yun
    • , Michael Haugbro
    • , Erica M. Briggs
    • , Vladimir Svetlov
    • , Evgeny Nudler
    • , Holger Knaut
    • , Richard Bonneau
    • , Michael J. Garabedian
    • , Kent Kirshenbaum
    •  & Susan K. Logan
  • Article | | open

    Tobacco smoking and cold exposure are environmental modulators of human energy metabolism suppressing appetite and increasing energy expenditure, respectively. Here, the authors develop a novel pharmacological strategy in which they simultaneously mimic the metabolic benefits of both phenomena through small-molecule combination therapy, and show that this treatment improves metabolic health of obese mice.

    • Christoffer Clemmensen
    • , Sigrid Jall
    • , Maximilian Kleinert
    • , Carmelo Quarta
    • , Tim Gruber
    • , Josefine Reber
    • , Stephan Sachs
    • , Katrin Fischer
    • , Annette Feuchtinger
    • , Angelos Karlas
    • , Stephanie E. Simonds
    • , Gerald Grandl
    • , Daniela Loher
    • , Eva Sanchez-Quant
    • , Susanne Keipert
    • , Martin Jastroch
    • , Susanna M. Hofmann
    • , Emmani B. M. Nascimento
    • , Patrick Schrauwen
    • , Vasilis Ntziachristos
    • , Michael A. Cowley
    • , Brian Finan
    • , Timo D. Müller
    •  & Matthias H. Tschöp
  • Article | | open

    The decision when to stop an intervention is a critical component of parasite elimination programmes, but reliance on surveillance data alone can be inaccurate. Here, Michael et al. combine parasite transmission model predictions with disease survey data to more reliably determine when interventions can be stopped.

    • Edwin Michael
    • , Morgan E. Smith
    • , Moses N. Katabarwa
    • , Edson Byamukama
    • , Emily Griswold
    • , Peace Habomugisha
    • , Thomson Lakwo
    • , Edridah Tukahebwa
    • , Emmanuel S. Miri
    • , Abel Eigege
    • , Evelyn Ngige
    • , Thomas R. Unnasch
    •  & Frank O. Richards
  • Article | | open

    Testing the association between genetic variants and a range of phenotypes can assist drug development. Here, in a phenome-wide association study in up to 697,815 individuals, Diogo et al. identify genotype–phenotype associations predicting efficacy, alternative indications or adverse drug effects.

    • Dorothée Diogo
    • , Chao Tian
    • , Christopher S. Franklin
    • , Mervi Alanne-Kinnunen
    • , Michael March
    • , Chris C. A. Spencer
    • , Ciara Vangjeli
    • , Michael E. Weale
    • , Hannele Mattsson
    • , Elina Kilpeläinen
    • , Patrick M. A. Sleiman
    • , Dermot F. Reilly
    • , Joshua McElwee
    • , Joseph C. Maranville
    • , Arnaub K. Chatterjee
    • , Aman Bhandari
    • , Khanh-Dung H. Nguyen
    • , Karol Estrada
    • , Mary-Pat Reeve
    • , Janna Hutz
    • , Nan Bing
    • , Sally John
    • , Daniel G. MacArthur
    • , Veikko Salomaa
    • , Samuli Ripatti
    • , Hakon Hakonarson
    • , Mark J. Daly
    • , Aarno Palotie
    • , David A. Hinds
    • , Peter Donnelly
    • , Caroline S. Fox
    • , Aaron G. Day-Williams
    • , Robert M. Plenge
    •  & Heiko Runz
  • Article | | open

    Combining decellularised scaffolds with patient-derived cells holds promise for bioengineering of functional tissues. Here the authors develop a two-stage approach to engineer an oesophageal graft that retains the structural organisation of native oesophagus.

    • Luca Urbani
    • , Carlotta Camilli
    • , Demetra-Ellie Phylactopoulos
    • , Claire Crowley
    • , Dipa Natarajan
    • , Federico Scottoni
    • , Panayiotis Maghsoudlou
    • , Conor J. McCann
    • , Alessandro Filippo Pellegata
    • , Anna Urciuolo
    • , Koichi Deguchi
    • , Sahira Khalaf
    • , Salvatore Ferdinando Aruta
    • , Maria Cristina Signorelli
    • , David Kiely
    • , Edward Hannon
    • , Matteo Trevisan
    • , Rui Rachel Wong
    • , Marc Olivier Baradez
    • , Dale Moulding
    • , Alex Virasami
    • , Asllan Gjinovci
    • , Stavros Loukogeorgakis
    • , Sara Mantero
    • , Nikhil Thapar
    • , Neil Sebire
    • , Simon Eaton
    • , Mark Lowdell
    • , Giulio Cossu
    • , Paola Bonfanti
    •  & Paolo De Coppi
  • Article | | open

    Hidden hearing loss (HHL) arises through subtle damage to the synapses of hair cells in the inner ear before audiograms reveal hearing threshold shifts. Here, the authors report that HHL in a mouse model disrupts the neural encoding of loud sound environments in the central auditory system.

    • Warren Michael Henry Bakay
    • , Lucy Anne Anderson
    • , Jose Alberto Garcia-Lazaro
    • , David McAlpine
    •  & Roland Schaette
  • Article | | open

    Studies on the effects of breastfeeding on the infant gut microbiota have provided inconsistent results. Here, Ho et al. perform a meta-analysis of seven studies across different populations, supporting that exclusive breastfeeding is associated with short-term and long-term alterations in the infant gut microbiota.

    • Nhan T. Ho
    • , Fan Li
    • , Kathleen A. Lee-Sarwar
    • , Hein M. Tun
    • , Bryan P. Brown
    • , Pia S. Pannaraj
    • , Jeffrey M. Bender
    • , Meghan B. Azad
    • , Amanda L. Thompson
    • , Scott T. Weiss
    • , M. Andrea Azcarate-Peril
    • , Augusto A. Litonjua
    • , Anita L. Kozyrskyj
    • , Heather B. Jaspan
    • , Grace M. Aldrovandi
    •  & Louise Kuhn
  • Article | | open

    Long-acting (LA) formulations of antiretroviral (ARV) drugs are an alternative approach to improve adherence for HIV treatment and prevention. Here the authors show a removable biodegradable ultra-LA-ARV drug system that effectively delivers drug, controls viremia and prevents infection in animal models of HIV infection.

    • Martina Kovarova
    • , S. Rahima Benhabbour
    • , Ivana Massud
    • , Rae Ann Spagnuolo
    • , Brianna Skinner
    • , Caroline E. Baker
    • , Craig Sykes
    • , Katie R. Mollan
    • , Angela D. M. Kashuba
    • , J. Gerardo García-Lerma
    • , Russell J. Mumper
    •  & J. Victor Garcia