News & Views |
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News |
New pill helps COVID smell and taste loss fade quickly
The antiviral drug ensitrelvir, which shortens sensory problems, is one of the few COVID-19 drugs available to people not at high risk of grave illness.
- Mariana Lenharo
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Article
| Open AccessTargeting myeloid chemotaxis to reverse prostate cancer therapy resistance
A translational study demonstrates the role of myeloid inflammatory cells in driving disease progression and treatment resistance in prostate cancer and shows that these cells can be targeted therapeutically.
- Christina Guo
- , Adam Sharp
- & Johann S. de Bono
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News Explainer |
Anti-obesity drugs’ side effects: what we know so far
Recent studies evaluate risks associated with drugs such as Wegovy and Mounjaro.
- Mariana Lenharo
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News |
This is the largest map of the human brain ever made
Researchers catalogue more than 3,000 different types of cell in our most complex organ.
- Gemma Conroy
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News & Views |
Pig-to-primate organ transplants require genetic modifications of donor
A raft of alterations to the pig genome — removing three antigen-encoding genes, adding seven human genes and eliminating a retrovirus — allows kidneys to be transplanted into monkeys, with implications for clinical trials.
- Muhammad M. Mohiuddin
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News |
Monkey survives for two years after gene-edited pig-kidney transplant
Survival time is one of the longest for any interspecies transplant — and moves pig organs closer to human use.
- Max Kozlov
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Article
| Open AccessApoptotic stress causes mtDNA release during senescence and drives the SASP
During senescence, minority mitochondrial outer membrane permeabilization leads to the release of mtDNA into the cytosol through BAX and BAK macropores, in turn activating the cGAS–STING pathway, a major regulator of the senescence-associated secretory phenotype.
- Stella Victorelli
- , Hanna Salmonowicz
- & João F. Passos
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Article
| Open AccessDesign and testing of a humanized porcine donor for xenotransplantation
Using kidneys from a genetically engineered porcine donor transplanted into a cynomolgus monkey model, the design, creation and long-term function of kidney grafts supporting life are explored.
- Ranjith P. Anand
- , Jacob V. Layer
- & Wenning Qin
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Correspondence |
Collateral damage from accelerated drug approval
- Akihiko Ozaki
- , Kenji Gonda
- & Tetsuya Tanimoto
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News & Views |
From the archive: science on TV, and the Lancet turns 100
Snippets from Nature’s past.
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News |
Gene therapies for rare diseases are under threat. Scientists hope to save them
As industry steps aside, scientists seek innovative ways to make sure expensive treatments can reach people who need them.
- Heidi Ledford
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News Feature |
Why rings of RNA could be the next blockbuster drug
The commercial success of RNA vaccines for COVID-19 has revved up interest in circular RNAs as the next generation of therapies.
- Elie Dolgin
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Article
| Open AccessThe PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity
An orally bioavailable small-molecule active-site inhibitor of the phosphatases PTPN2 and PTPN1, ABBV-CLS-484, demonstrates immunotherapeutic efficacy in mouse models of cancer resistant to PD-1 blockade.
- Christina K. Baumgartner
- , Hakimeh Ebrahimi-Nik
- & Robert T. Manguso
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Comment |
Why researchers should use human embryo models with caution
Scientists should carefully consider whether embryo models based on human stem cells are essential to their work because of the associated practical and ethical challenges.
- Janet Rossant
- & Jianping Fu
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Outlook |
RSV treatments are here: now the work begins
Efforts to prevent infections and keep vulnerable people out of hospital are beginning to pay off, but deploying these strategies presents new challenges.
- Benjamin Plackett
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Outlook |
Antibody therapies set to transform respiratory syncytial virus prevention for babies
Drugs that counter RSV infection can safeguard newborns, offering another mode of protection alongside vaccines.
- Elie Dolgin
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Outlook |
Research round-up: respiratory syncytial virus
Why monitoring sewers could help to detect outbreaks, how RSV and flu viruses can couple together and other highlights.
- Liam Drew
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News |
Is depression lifting? AI that interprets brain waves has answers
A pattern of brain activity linked with recovery from severe depression could be used to improve therapies such as deep-brain stimulation
- Max Kozlov
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Article
| Open AccessCingulate dynamics track depression recovery with deep brain stimulation
This study demonstrates how activity in the cingulate cortex tracks depression recovery, providing symptom relief using deep brain stimulation.
- Sankaraleengam Alagapan
- , Ki Sueng Choi
- & Christopher J. Rozell
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Article |
A multi-stem cell basis for craniosynostosis and calvarial mineralization
The calvarial stem cell niche is populated by a cathepsin K-expressing cell lineage and a newly identified discoidin domain-containing receptor 2-expressing lineage, both of which are required for proper calvarial mineralization.
- Seoyeon Bok
- , Alisha R. Yallowitz
- & Matthew B. Greenblatt
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News & Views |
From the archive: harmful insects, and Michael Faraday battles jargon
Snippets from Nature’s past.
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News |
Super-precise CRISPR tool enters US clinical trials for the first time
Base editing, which makes specific changes to a cell’s genome, is put to the test in CAR-T-cell treatments for leukaemia.
- Heidi Ledford
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Research Highlight |
A vaccine against the cervical-cancer virus shows its prowess
In a large trial, not a single participant developed a serious precancerous lesion caused by a vaccine-targeted viral type.
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News Feature |
Human trials of artificial wombs could start soon. Here’s what you need to know
US regulators will consider clinical trials of a system that mimics the womb, which could reduce deaths and disability for babies born extremely preterm.
- Max Kozlov
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News & Views |
Stem cells provide clues to why vertebrae attract tumour cells
Tumour cells tend to migrate to the vertebrae rather than to long bones, but the mechanism underlying this has been unclear. It emerges that the stem cells from which vertebrae are derived make a factor that attracts tumour cells.
- Geert Carmeliet
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News |
Breast cancer often spreads to the spine — newfound stem cell can explain why
A stem cell that contributes to vertebra formation also encourages the growth of tumours that move to the backbone from elsewhere.
- Saima Sidik
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Article
| Open AccessChild wasting and concurrent stunting in low- and middle-income countries
An analysis of longitudinal cohort data across diverse populations suggests that the incidence of wasting between birth and 24 months is higher than previously thought, and highlights the role of seasonal factors that affect child growth.
- Andrew Mertens
- , Jade Benjamin-Chung
- & Pablo Penataro Yori
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Article
| Open AccessEarly-childhood linear growth faltering in low- and middle-income countries
A pooled analysis of longitudinal studies in low- and middle-income countries identifies the typical age of onset of linear growth faltering and investigates recurrent faltering in early life.
- Jade Benjamin-Chung
- , Andrew Mertens
- & Pablo Penataro Yori
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Article
| Open AccessA foundation model for generalizable disease detection from retinal images
RETFound, a foundation model for retinal images that learns generalizable representations from unlabelled images, is trained on 1.6 million unlabelled images by self-supervised learning and then adapted to disease detection tasks with explicit labels.
- Yukun Zhou
- , Mark A. Chia
- & Pearse A. Keane
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Article
| Open AccessCauses and consequences of child growth faltering in low-resource settings
Analysis of data from 33 longitudinal cohorts from low- and middle-income countries indicates that conditions during pre-conception, pregnancy and the first few months of life are crucial in determining the risk of growth faltering in young children.
- Andrew Mertens
- , Jade Benjamin-Chung
- & Pablo Penataro Yori
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Nature Index |
Global leaders in science’s battle against cancer
A look at the key research institutions, funders and collaborations that are driving the field forward.
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Nature Index |
African scientists call for research equity as a cancer crisis looms
Rising death rates are defying global trends but the continent’s researchers are keen to lead the fightback.
- Linda Nordling
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Nature Index |
Ukraine seeks to resume its role in cancer clinical trials
The country was making a key contribution before Russia’s invasion.
- Rachel Nuwer
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Nature Index |
The gross imbalances of cancer research must be addressed
A zealous focus on discovery should not come at the expense of improving basic intervention.
- Richard Sullivan
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Nature Index |
Four ways research aims to outwit cancer’s evasion tactics
From AI-enabled drug discovery to therapeutic vaccines, science is opening up fresh angles of attack against the disease.
- Michael Eisenstein
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Nature Index |
Can cancer research shift its focus?
Misdirected funds could be undermining efforts to improve patient outcomes in regions that need it most.
- Bec Crew
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News |
Medical-evidence giant Cochrane battles funding cuts and closures
The group that helped to revolutionize medical practice has lost key funding and is reorganizing — moves that concern some researchers.
- Helen Pearson
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News Feature |
A DIY ‘bionic pancreas’ is changing diabetes care — what's next?
A community of people with type 1 diabetes got a self-built device approved. What can they offer that big companies can’t?
- Liam Drew
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Nature Podcast |
Audio long read: Medicine is plagued by untrustworthy clinical trials. How many studies are faked or flawed?
Teams of scientists, physicians and data sleuths argue that in some fields unreliable or fabricated trials are widespread.
- Richard Van Noorden
- & Benjamin Thompson
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News & Views |
Brain implants that enable speech pass performance milestones
Two brain–computer interfaces have been developed that bring unprecedented capabilities for translating brain signals into sentences — at speeds close to that of normal speech, and with vocabularies exceeding 1,000 words.
- Nick F. Ramsey
- & Nathan E. Crone
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News |
Brain-reading devices allow paralysed people to talk using their thoughts
Two studies report considerable improvements in technologies designed to help people with facial paralysis to communicate.
- Miryam Naddaf
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Review Article |
From target discovery to clinical drug development with human genetics
This Review provides a perspective on the development of non-cancer therapies based on human genetics studies and suggests measures that can be taken to streamline the pipeline from initial genetic discovery to approved therapy.
- Katerina Trajanoska
- , Claude Bhérer
- & Vincent Mooser
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Career Q&A |
Leveraging my training in space medicine for technological innovation
Shawna Pandya explores entrepreneurial niches to bring virtual-reality medicine to space exploration.
- Lesley Evans Ogden
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News |
WHO’s first traditional medicine summit splits opinions
The World Health Organization says the world-first summit will take an evidence-based approach — some are sceptical that much progress will be made.
- Gayathri Vaidyanathan
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News & Views |
Immune treatment tackles chronic obstructive pulmonary disease
Smoking causes chronic obstructive pulmonary disease. Some people with this disease have high levels of eosinophil cells, which is typical of the type 2 category of inflammation, and blocking such inflammation improves their lung health.
- John V. Fahy
- & Richard M. Locksley
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News & Views |
Calligraphy tool offers clues to the origin of pancreatic cancer
Understanding the processes that lead to tumour formation in the pancreas might help in efforts to develop therapies. A new bioinformatics tool called Calligraphy analyses cell–cell signalling to provide fresh insights into how tumours arise.
- Filip Bednar
- & Marina Pasca di Magliano
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Article |
Interferon-ε is a tumour suppressor and restricts ovarian cancer
Interferon-ε is a tumour suppressor expressed in the epithelial cell of origin of ovarian cancer, which it restricts by direct action on tumour cells and especially by activation of anti-tumour immunity.
- Zoe R. C. Marks
- , Nicole K. Campbell
- & Paul J. Hertzog
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Research Highlight |
Breast-cancer screening gets a boost from AI
Supplementing human expertise with an automated program means catching more cancers.