Mechanotransduction

Mechanotransduction refers to the processes through which cells sense and respond to mechanical stimuli by converting them to biochemical signals that elicit specific cellular responses.

Latest Research and Reviews

  • Research | | open

    SREBP transcription factors activate lipid synthesis and generate raw materials to lipidate various proteins. Here, the authors show that a stiff cellular environment causes RhoA lipidation and acto-myosin contraction, which inhibits SREBP1 and connects the extracellular matrix to lipid metabolism.

    • Rebecca Bertolio
    • , Francesco Napoletano
    • , Miguel Mano
    • , Sebastian Maurer-Stroh
    • , Marco Fantuz
    • , Alessandro Zannini
    • , Silvio Bicciato
    • , Giovanni Sorrentino
    •  & Giannino Del Sal
  • Research | | open

    Phagocytosis of pathogens is thought to proceed through the sequential engagement of Fc-receptors on the phagocyte with antibodies on the target surface. Here authors show that myosin 1e and myosin 1f link the actin cytoskeleton to the membrane and are required for efficient phagocytosis of antibody-opsonized targets.

    • Sarah R. Barger
    • , Nicholas S. Reilly
    • , Maria S. Shutova
    • , Qingsen Li
    • , Paolo Maiuri
    • , John M. Heddleston
    • , Mark S. Mooseker
    • , Richard A. Flavell
    • , Tatyana Svitkina
    • , Patrick W. Oakes
    • , Mira Krendel
    •  & Nils C. Gauthier
  • Research | | open

    How cells migrate in fibrous tissues is still poorly understood. Here, with synthetic 3D fibre matrices of controlled alignment and stiffness, the authors report that cells in stiff matrices move slowly and continuously, but in softer, deformable matrices cells can rapidly slingshot forward via stretch and recoil of matrix fibres.

    • William Y. Wang
    • , Christopher D. Davidson
    • , Daphne Lin
    •  & Brendon M. Baker
  • Research | | open

    The mechano-properties of the Extracellular Matrix (ECM) are important for tumorigenesis. Here, the authors show that the stiffening of the ECM promotes translocation of the focal adhesion protein—Kindlin-2—to the mitochondria, where it interacts with the proline synthesis enzyme PYCR1, stimulating proline synthesis and cell proliferation.

    • Ling Guo
    • , Chunhong Cui
    • , Kuo Zhang
    • , Jiaxin Wang
    • , Yilin Wang
    • , Yixuan Lu
    • , Ka Chen
    • , Jifan Yuan
    • , Guozhi Xiao
    • , Bin Tang
    • , Ying Sun
    •  & Chuanyue Wu
  • Research |

    Moro et al. discover an Argonaute 2 (Ago2)-dependent miRNA network that, in response to substrate stiffness, regulates genes involved in tissue mechanics, and show that Ago2 restrains stiffness and contributes to regeneration in the zebrafish fin fold.

    • Albertomaria Moro
    • , Tristan P. Driscoll
    • , Liana C. Boraas
    • , William Armero
    • , Dionna M. Kasper
    • , Nicolas Baeyens
    • , Charlene Jouy
    • , Venkatesh Mallikarjun
    • , Joe Swift
    • , Sang Joon Ahn
    • , Donghoon Lee
    • , Jing Zhang
    • , Mengting Gu
    • , Mark Gerstein
    • , Martin Schwartz
    •  & Stefania Nicoli
    Nature Cell Biology 21, 348-358
  • Research |

    Romani et al. identify a response to reduced actomyosin contractility involving inhibition of Lipin-1, accumulation of SREBP transcription factors at the Golgi apparatus and activation of SREBP transcription driving increased lipid synthesis.

    • Patrizia Romani
    • , Irene Brian
    • , Giulia Santinon
    • , Arianna Pocaterra
    • , Matteo Audano
    • , Silvia Pedretti
    • , Samuel Mathieu
    • , Mattia Forcato
    • , Silvio Bicciato
    • , Jean-Baptiste Manneville
    • , Nico Mitro
    •  & Sirio Dupont
    Nature Cell Biology 21, 338-347

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