Mechanotransduction

Definition

Mechanotransduction refers to the processes through which cells sense and respond to mechanical stimuli by converting them to biochemical signals that elicit specific cellular responses.

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Latest Research and Reviews

  • Reviews |

    The dynamics of epithelial tissues play a key role in tissue organization, both in health and disease. In this Review, the authors discuss materials and techniques for the study of epithelial movement and mechanics and investigate epithelia as active matter from a theoretical and experimental perspective.

    • Wang Xi
    • , Thuan Beng Saw
    • , Delphine Delacour
    • , Chwee Teck Lim
    •  & Benoit Ladoux
  • Research | | open

    Mechanical and metabolic cues contribute to regulate cell and tissue homeostasis but how they are integrated is not known. Here the authors show that the amino acid transporter and integrin coreceptor CD98hc regulates mechanical signaling downstream of integrins indirectly through regulating sphingolipid availability.

    • Etienne Boulter
    • , Soline Estrach
    • , Floriane S. Tissot
    • , Marco L. Hennrich
    • , Lionel Tosello
    • , Laurence Cailleteau
    • , Laura R. de la Ballina
    • , Sabrina Pisano
    • , Anne-Claude Gavin
    •  & Chloé C. Féral
  • Research |

    Barnes et al. report a dynamic and reciprocal crosstalk between tissue tension and glycocalyx bulkiness that promotes a mesenchymal, stem-like phenotype in GBM.

    • J. Matthew Barnes
    • , Shelly Kaushik
    • , Russell O. Bainer
    • , Jason K. Sa
    • , Elliot C. Woods
    • , FuiBoon Kai
    • , Laralynne Przybyla
    • , Mijeong Lee
    • , Hye Won Lee
    • , Jason C. Tung
    • , Ori Maller
    • , Alexander S. Barrett
    • , Kan V. Lu
    • , Jonathon N. Lakins
    • , Kirk C. Hansen
    • , Kirsten Obernier
    • , Arturo Alvarez-Buylla
    • , Gabriele Bergers
    • , Joanna J. Phillips
    • , Do-Hyun Nam
    • , Carolyn R. Bertozzi
    •  & Valerie M. Weaver
    Nature Cell Biology 20, 1203–1214
  • Research |

    Studying early Drosophila wing epithelium development, Singh et al. find that individual cells are mechanically autonomous, and that their elongation along the proximal–distal axis is driven by polarized microtubule-mediated pushing forces.

    • Amrita Singh
    • , Tanumoy Saha
    • , Isabell Begemann
    • , Andrea Ricker
    • , Harald Nüsse
    • , Oliver Thorn-Seshold
    • , Jürgen Klingauf
    • , Milos Galic
    •  & Maja Matis
    Nature Cell Biology 20, 1126–1133
  • Reviews |

    Stefano Piccolo and co-authors review recent insights into how YAP and TAZ transcription factors respond to the tissue environment, and how they mediate altered cell behaviour. Feedback mechanisms and crosstalk with other pathways are discussed, as are outstanding questions in the field.

    • Antonio Totaro
    • , Tito Panciera
    •  & Stefano Piccolo
    Nature Cell Biology 20, 888–899

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