Mechanotransduction

Mechanotransduction refers to the processes through which cells sense and respond to mechanical stimuli by converting them to biochemical signals that elicit specific cellular responses.

Latest Research and Reviews

  • Reviews |

    Mechanical forces are important regulators of cell function and behaviour. This role is partly achieved through the modulation of cell metabolism, which, reciprocally, affects tissue mechanics. Unravelling the mechanisms of this crosstalk will increase our understanding of how cells interact with their microenvironment.

    • Patrizia Romani
    • , Lorea Valcarcel-Jimenez
    • , Christian Frezza
    •  & Sirio Dupont
  • Research
    | Open Access

    Kimura et al. reports a refined human skin equivalent (HSE) model that reproduces traction-force balance in the lateral direction. This tension improves HSE characteristics and promotes skin homeostasis. This model has great potential for applications in drug screening and understanding the molecular mechanisms of drug effects, skin ageing and diseases.

    • Shun Kimura
    • , Ayako Tsuchiya
    • , Miho Ogawa
    • , Miki Ono
    • , Nao Suda
    • , Kaori Sekimoto
    • , Makoto Takeo
    •  & Takashi Tsuji
  • Reviews |

    The dynamic epigenetic landscape directs gene expression patterns that regulate cellular form and function. Designer cell culture materials have shed light on how materials cues influence cellular plasticity through the epigenome and directed tissue-fabrication approaches that drive biological activities.

    • Stephanie Nemec
    •  & Kristopher A. Kilian
  • Research |

    Mathematical and experimental approaches are used to investigate the mechanical forces that shape the tumour architecture of two different common forms of skin cancer: basal cell carcinomas and invasive squamous cell carcinomas.

    • Vincent F. Fiore
    • , Matej Krajnc
    • , Felipe Garcia Quiroz
    • , John Levorse
    • , H. Amalia Pasolli
    • , Stanislav Y. Shvartsman
    •  & Elaine Fuchs
    Nature 585, 433-439
  • Research |

    A mechanism of cell response to localized tension shows that syndecan-4 synergizes with EGFR to elicit a mechanosignalling cascade that leads to adaptive cell stiffening through PI3K/kindlin-2 mediated integrin activation.

    • Antonios Chronopoulos
    • , Stephen D. Thorpe
    • , Ernesto Cortes
    • , Dariusz Lachowski
    • , Alistair J. Rice
    • , Vasyl V. Mykuliak
    • , Tomasz Róg
    • , David A. Lee
    • , Vesa P. Hytönen
    •  & Armando E. del Río Hernández
    Nature Materials 19, 669-678

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