Mechanisms of disease articles within Nature Communications

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• Article
  10 December 2022 | Open Access

  Mitochondrial dysfunction induces ALK5-SMAD2-mediated hypovascularization and arteriovenous malformations in mouse retinas

  The role of mitochondrial activity in angiogenesis is not entirely understood. Here, the authors show that mitochondria as a signaling hub and their dysfunction causes augmented TGFβ signaling to induce retinal sprouting retardation and vascular malformations.

  • Haifeng Zhang
  • , Busu Li
  •  & Jenny Huanjiao Zhou

• Article
  10 December 2022 | Open Access

  Sirt6 attenuates chondrocyte senescence and osteoarthritis progression

  Ji and colleagues identify Sirt6 as a regulator of chondrocyte senescence. Mechanistically, Sirt6 physically interacts with STAT5 and deacetylates it at K163, which reduces the IL-15/JAK3-induced STAT5 translocation from cytoplasm to nucleus.

  • Ming-liang Ji
  • , Hua Jiang
  •  & Jun Lu

• Article
  08 December 2022 | Open Access

  Slow growing behavior in African trypanosomes during adipose tissue colonization

  Trypanosoma brucei parasites invade different organs, such as the central nervous system, adipose tissue, and skin in mammalian host. Here, Trindade et al. perform mathematical modelling to show that adipose tissue forms (ATFs) grow slower than the bloodstream forms and experimentally characterize the heterogeneous ATF populations and provide evidence that slow-growing forms are refractory to drug treatment.

  • Sandra Trindade
  • , Mariana De Niz
  •  & Luisa M. Figueiredo

• Article
  05 December 2022 | Open Access

  Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease

  Repair processes in kidney are impaired in severe disease. Here, the authors show that in kidney failure, genetic or pharmacologic inhibition of IL11 releases the brake on regeneration, reverses tissue damage and restores kidney function.

  • Anissa A. Widjaja
  • , Sivakumar Viswanathan
  •  & Stuart A. Cook

• Article
  26 November 2022 | Open Access

  Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins

  White adipose tissue browning plays an important role in regulating whole-body energy homeostasis and metabolism. Here the authors show that the HMGN nucleosome binding proteins epigenetically promote white adipocyte differentiation and modulate the rate of white adipose tissue browning and energy metabolism in male mice.

  • Ravikanth Nanduri
  • , Takashi Furusawa
  •  & Michael Bustin

• Article
  22 November 2022 | Open Access

  A non-coding GWAS variant impacts anthracycline-induced cardiotoxic phenotypes in human iPSC-derived cardiomyocytes

  Germline variants may pre-dispose patients to an increased risk of developing anthracycline-induced cardiotoxicity. This report provides insights into the mechanism by which a common genetic variant, rs28714259, may confer an increased risk of cardiac damage.

  • Xi Wu
  • , Fei Shen
  •  & Bryan Paul Schneider

• Article
  21 November 2022 | Open Access

  Regulome analysis in B-acute lymphoblastic leukemia exposes Core Binding Factor addiction as a therapeutic vulnerability

  The ETV6-RUNX1 chimeric- and native RUNX1-responsive regulomes in paediatric B-acute lymphoblastic leukemia (B-ALL) remain to be characterized. Here, the authors reveal functional antagonism between the two transcription factors predominantly for the regulation of cell cycle-associated pathways and dependency on native RUNX1 for tumorigenesis which can be targeted pharmacologically.

  • Jason P. Wray
  • , Elitza M. Deltcheva
  •  & Tariq Enver

• Article
  19 November 2022 | Open Access

  PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis

  Currently, there is a lack of effective drugs for the treatment of pulmonary fibrosis. Here, the authors reveal a novel role of PEAR1 in fibroblast activation and demonstrate that activating PEAR1 by monoclonal antibodies might be a promising therapeutic approach for pulmonary fibrosis.

  • Yan Geng
  • , Lin Li
  •  & Xuemei Fan

• Article
  19 November 2022 | Open Access

  Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation

  Here, authors show that Smad3 acetylation via HDAC6 inhibition reverses Duchenne muscular dystrophy-like symptoms in the mdx mouse model, suggesting a potential therapeutic target for the disorder.

  • Alexis Osseni
  • , Aymeric Ravel-Chapuis
  •  & Laurent Schaeffer

• Article
  17 November 2022 | Open Access

  Ciliary neurotrophic factor-mediated neuroprotection involves enhanced glycolysis and anabolism in degenerating mouse retinas

  Rhee et al. demonstrates that the potent neuroprotective agent CNTF significantly impacts metabolism of degenerating retinas, thus revealing cellular mechanisms underlying enhanced neuronal viability and providing insight for the ongoing CNTF clinical trials.

  • Kun Do Rhee
  • , Yanjie Wang
  •  & Xian-Jie Yang

• Article
  17 November 2022 | Open Access

  CHD7 regulates otic lineage specification and hair cell differentiation in human inner ear organoids

  Mutations in the chromatin remodeler CHD7 cause CHARGE syndrome, affecting development of several organs including the inner ear. Here, the authors recapitulated pathogenesis of this disease with human inner ear organoids and found that CHD7 is indispensable for proper otic lineage specification and hair cell differentiation.

  • Jing Nie
  • , Yoshitomo Ueda
  •  & Eri Hashino

• Matters Arising
  14 November 2022 | Open Access

  The stress-inducible ER chaperone GRP78/BiP is upregulated during SARS-CoV-2 infection and acts as a pro-viral protein

  • Woo-Jin Shin
  • , Dat P. Ha
  •  & Amy S. Lee

• Article
  14 November 2022 | Open Access

  Replication collisions induced by de-repressed S-phase transcription are connected with malignant transformation of adult stem cells

  Suppression of transcription in S-phase is crucial to prevent genome instability. Zhang et al demonstrate that increase of H4K20me1 due to loss of Kmt5b cause genome instability in muscle stem cells, resulting in stem cell senescence but rhabdomyosarcoma formation when p53 is inactivated.

  • Ting Zhang
  • , Carsten Künne
  •  & Thomas Braun

• Article
  14 November 2022 | Open Access

  Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells

  Chronic hyperglycemia impairs insulin secretion from pancreatic beta cells in diabetes. Here, the authors reveal that a glucose metabolite is responsible and show lowering glucose metabolism during hyperglycemia prevents loss of beta-cell function.

  • Elizabeth Haythorne
  • , Matthew Lloyd
  •  & Frances M. Ashcroft

• Article
  11 November 2022 | Open Access

  pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation

  Small proteins encoded by previously assumed non-coding RNAs can have cell regulatory functions. Here the authors report that TINCR lncRNA encodes pTINCR, a ubiquitin-like protein (UBL) that promotes epithelial differentiation through the SUMOylation and activation of CDC42, and it has tumour suppressor activity in epithelial cancers.

  • Olga Boix
  • , Marion Martinez
  •  & María Abad

• Article
  11 November 2022 | Open Access

  Differential impact of ubiquitous and muscle dynamin 2 isoforms in muscle physiology and centronuclear myopathy

  Dynamin 2 is a large GTPase linked to several human diseases. Here, Gómez-Oca et al. investigate the functions of muscle dynamin 2 isoforms and provide insights into their differential implication in centronuclear myopathy pathogenesis and treatment.

  • Raquel Gómez-Oca
  • , Evelina Edelweiss
  •  & Jocelyn Laporte

• Article
  10 November 2022 | Open Access

  Ferritin triggers neutrophil extracellular trap-mediated cytokine storm through Msr1 contributing to adult-onset Still’s disease pathogenesis

  Hyperferritinemic syndrome is a collective term for a group of severe inflammatory conditions distinguished by high ferritin levels, including adult-onset Still’s disease and COVID-19. Here authors show in an animal model that high ferritin levels are not just a sign of hyperinflammation but also a pathogenic factor that triggers neutrophil leukocyte activation and extracellular trap formation.

  • Jinchao Jia
  • , Mengyan Wang
  •  & Qiongyi Hu

• Article
  09 November 2022 | Open Access

  Reversible Myc hypomorphism identifies a key Myc-dependency in early cancer evolution

  Happloinsufficiency of Myc delays onset of cancers in mice. Here, the authors generated a mouse model of reversible cMyc hypomorphism and show that metronomic reduction of c-Myc in adult mice confers protection against cancers without side effects and that the bottleneck in early cancer evolution is dependent upon Myc.

  • Nicole M. Sodir
  • , Luca Pellegrinet
  •  & Gerard I. Evan

• Article
  03 November 2022 | Open Access

  Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation

  Cytoplasmic accumulation of RNA binding protein, hnRNPK in cancer cells is associated with poor prognosis. Here the authors show that SCF^Fbxo4 E3 ubiquitin ligase-mediated polyubiquitylation of hnRNPK restricts c-Myc translation and limits cancer progression.

  • Bartosz Mucha
  • , Shuo Qie
  •  & J. Alan Diehl

• Article
  03 November 2022 | Open Access

  The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision

  Motile and non-motile cilia have distinct functions and protein complexes associated with them. Here, the authors show the conserved protein CFAP20 is important for both motile and non-motile cilia and is distinct from other ciliopathy-associated domains or macromolecular complexes.

  • Paul W. Chrystal
  • , Nils J. Lambacher
  •  & Michel R. Leroux

• Article
  31 October 2022 | Open Access

  Circular RNA circBNC2 inhibits epithelial cell G2-M arrest to prevent fibrotic maladaptive repair

  G2/M arrest of epithelial cells leads to fibrosis with unclear mechanisms. This study identifies a protein-encoding circRNA, circBNC2, which inhibits epithelial cells G2/M arrest to prevent fibrotic maladaptive repair in damaged kidney and liver, revealing a potential intervention target for fibrosis.

  • Peng Wang
  • , Zhitao Huang
  •  & Fan Fan Hou

• Article
  30 October 2022 | Open Access

  Sexually dimorphic estrogen sensing in skeletal stem cells controls skeletal regeneration

  How bone-related sexually dimorphic traits are regulated hasn’t been examined at the stem cell level. Here the authors show that skeletal stem cells (SSC), in female but not male mice, are directly controlled by estrogen signaling, which could be augmented to improve fracture repair.

  • Tom W. Andrew
  • , Lauren S. Koepke
  •  & Charles K. F. Chan

• Article
  30 October 2022 | Open Access

  Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis

  Autosomal dominant polycystic kidney disease (ADPKD) is a complicated disease that involves numerous cell types. Here the authors used a multiomics approach consisting of single nucleus transcriptomes and epigenomes to redefine cell states in ADPKD and to dissect the cellular interactions and molecular mechanisms of ADPKD.

  • Yoshiharu Muto
  • , Eryn E. Dixon
  •  & Benjamin D. Humphreys

• Article
  27 October 2022 | Open Access

  Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation

  The epithelial protein Coxsackievirus Adenovirus Receptor (CAR) is a virus receptor but may have other functions. Here the authors show that deletion of CAR in mice leads to reduced house dust mite-induced lung inflammation, reduced neutrophil accumulation and alterations in airway remodelling.

  • Elena Ortiz-Zapater
  • , Dustin C. Bagley
  •  & Maddy Parsons

• Article
  23 October 2022 | Open Access

  A noncanonical function of EIF4E limits ALDH1B1 activity and increases susceptibility to ferroptosis

  Ferroptosis is lipid peroxidation-dependent cell death that has potential to be harnessed as a cancer therapeutic. Here, the authors show that the translation initiation factor eIF4E can repress ALDH1B1 independent of translation, increasing lipid peroxidation levels to promote ferroptosis.

  • Xin Chen
  • , Jun Huang
  •  & Rui Kang

• Article
  20 October 2022 | Open Access

  Systems-biology analysis of rheumatoid arthritis fibroblast-like synoviocytes implicates cell line-specific transcription factor function

  Fibroblast-like synoviocytes (FLS) are used as a model of rheumatoid arthritis synoviocytes, although cell lines derived from individual patients can have heterogeneous biology. Here the authors use a Taiji computational approach to analyze gene expression, chromatin accessibility and functional differences between individual patient-derived RA FLS lines.

  • Richard I. Ainsworth
  • , Deepa Hammaker
  •  & Wei Wang

• Article
  18 October 2022 | Open Access

  Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts

  The intercalated disc (ICD) is a membrane structure of the cardiac muscle involved in normal heart function. Here the authors report that knockdown of the ICD-bound transmembrane protein 65 results in impaired ICD structure, abnormal cardiac electrophysiology and cardiomyopathy in mice.

  • Allen C. T. Teng
  • , Liyang Gu
  •  & Anthony O. Gramolini

• Article
  14 October 2022 | Open Access

  Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D

  Alcohol consumption promotes neutral fat accumulation in the liver. Here, the authors report that alcohol induces aryl hydrocarbon receptor AhR in the liver, and hepatocyte-specific AhR deletion protects against alcohol induced accumulation potentially via transcriptional regulation of Protein phosphatase 2 regulatory subunit Bdelta and subsequent effects on autophagy.

  • Yun Seok Kim
  • , Bongsub Ko
  •  & Sang Geon Kim

• Article
  11 October 2022 | Open Access

  S100A8-mediated metabolic adaptation controls HIV-1 persistence in macrophages in vivo

  HIV-1 eradication is hindered by viral persistence in different cell reservoirs, including circulatory CD4+ T-cells and tissue-resident macrophages. Here, by analyzing male genital mucosa from cART-suppressed HIV1-infected individuals, Real et al. show that M4 macrophages represent the major macrophage HIV-1 reservoir in this tissue. These macrophages have an inflammatory IL1R⁺S100A8⁺MMP7⁺M4-phenotype, and contain transcriptionally active HIV-1, which reactivate infectious virus production from viral latency in response to autocrine/paracrine S100A8-mediated glycolysis.

  • Fernando Real
  • , Aiwei Zhu
  •  & Morgane Bomsel

• Article
  29 September 2022 | Open Access

  SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner

  Visceral adiposity is a risk factor for severe COVID-19, and infection of adipose tissue by SARS-CoV-2 has been reported. Here the authors confirm that human adipose tissue is a possible site for SARS-CoV-2 infection, but the degree of adipose tissue infection and the way adipocytes respond to the virus depend on the adipose tissue depot and the viral strain.

  • Tatiana Dandolini Saccon
  • , Felippe Mousovich-Neto
  •  & Marcelo A. Mori

• Article
  23 September 2022 | Open Access

  Intracellular energy controls dynamics of stress-induced ribonucleoprotein granules

  Stress granules are associated with neurodegenerative diseases. Here, Wang et al. found intracellular energy deficiencies trigger a unique type of granules and disrupt granule disassembly through 4EBP1/eIF4A.

  • Tao Wang
  • , Xibin Tian
  •  & Jiou Wang

• Article
  17 September 2022 | Open Access

  Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARγ during hyperlipidemia

  Identifying the mechanisms underlying the early inflammatory phase of aortic valve disease is crucial for disease prevention. Here the authors perform single-cell RNA sequencing to show the immunomodulatory role of PPARγ in valvular endothelial cells during hyperlipidemia.

  • Seung Hyun Lee
  • , Nayoung Kim
  •  & Jae-Hoon Choi

• Article
  13 September 2022 | Open Access

  Fatty acid metabolism in aggressive B-cell lymphoma is inhibited by tetraspanin CD37

  Tetraspanin CD37 deficiency has been reported as a prognostic marker for aggressive B-cell lymphoma. Here, the authors show that CD37 interacts with the fatty acid transporter 1 to inhibit palmitate uptake and its deficiency leads to increased fatty acid metabolism which promotes tumorigenesis in B-cell lymphoma.

  • Rens Peeters
  • , Jorge Cuenca-Escalona
  •  & Annemiek B. van Spriel

• Article
  12 September 2022 | Open Access

  GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway

  Lysosomal biogenesis errors often result in diseases including mucolipidosis. Here Zhang and Yang et al. identify TMEM251/GCAF as a mannose-6-phosphate modification regulator that is necessary for correct lysosomal targeting, and classify Mucolipidosis Type V as resulting from GCAF mutations.

  • Weichao Zhang
  • , Xi Yang
  •  & Ming Li

• Article
  09 September 2022 | Open Access

  CtIP-dependent nascent RNA expression flanking DNA breaks guides the choice of DNA repair pathway

  RNA has been implicated in DNA repair. This work shows that the interplay of RNAPII-generated nascent RNA, RNA:DNA hybrids and the resection factor CtIP guide DNA double strand break repair pathway choice towards error-free homologous recombination.

  • Daniel Gómez-Cabello
  • , George Pappas
  •  & Jiri Bartek

• Article
  03 September 2022 | Open Access

  Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression

  Spermidine, a polyamine reported to extend lifespan and reduce the risk of age-related diseases, serves as a substrate for the post-translational modification hypusination. Here the authors report that EIF5A hypusination, which regulates mitochondrial protein synthesis, is reduced during non-alcoholic steatohepatitis (NASH), which can be prevented by spermidine to inhibit the progression of NASH in mice.

  • Jin Zhou
  • , Jeremy Pang
  •  & Paul Michael Yen

• Article
  30 August 2022 | Open Access

  Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice

  Excessive expansion of cholangiocytes in the liver leads to ductular reaction and liver disease. Here, the authors show that genetic ablation, or pharmacological inhibition, of biliary NIK blocks ductular reaction, liver inflammation, and liver fibrosis in mice by modulating secretion of cholangiokines that mediate liver inflammation and fibrosis.

  • Zhiguo Zhang
  • , Xiao Zhong
  •  & Liangyou Rui

• Comment
  26 August 2022 | Open Access

  Paving the way to improve therapy for Myeloproliferative Neoplasms

  Long-acting IFNα induces durable molecular responses in myeloproliferative neoplasms. Emerging studies, including Saleiro et al. recently published in Nature Communications, have identified promising candidates that may synergise with IFNα by targeting stem cell function or feedback loops that mediate treatment resistance.

  • Megan Bywater
  •  & Steven W. Lane

• Article
  19 August 2022 | Open Access

  Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition

  Acute kidney injury can lead to chronic kidney disease. Here the authors show that the transition is related to a macrophage-mediated second wave of inflammatory cells that promote late tubule injury, dedifferentiation and fibrosis. Suppressing this second wave reduced tubular loss and kidney atrophy.

  • Leyuan Xu
  • , Jiankan Guo
  •  & Lloyd G. Cantley

• Article
  17 August 2022 | Open Access

  AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1

  Signaling via the mTOR complex 1 (mTORC1) maintains cellular and organismal homeostasis. Here the authors show that the AAA + ATPase Thorase binds mTOR to promote disassembly and inactivation of mTORC1 to fine tune TOR signaling according to amino acid availability.

  • George K. E. Umanah
  • , Leire Abalde-Atristain
  •  & Valina L. Dawson

• Article
  05 August 2022 | Open Access

  Disease-associated mutations within the yeast DNAJB6 homolog Sis1 slow conformer-specific substrate processing and can be corrected by the modulation of nucleotide exchange factors

  Here the authors describe mechanisms through which analogous LGMDD1 (Limb-Girdle Muscular Dystrophy Type D1) mutations affect Sis1 (a yeast functional homolog of human DNAJB6) chaperone activity and poison the function of wild-type protein; potentially uncovering a new therapeutic route to explore.

  • Ankan K. Bhadra
  • , Michael J. Rau
  •  & Heather L. True

• Article
  05 August 2022 | Open Access

  Club cells employ regeneration mechanisms during lung tumorigenesis

  Lung adenocarcinoma is a highly plastic tumour type. Here, the authors use single cell RNA sequencing to show that Club cells use regeneration mechanisms to develop tumours after an epigenetic switch towards an AT2-like phenotype shown by methylome analysis.

  • Yuanyuan Chen
  • , Reka Toth
  •  & Rocio Sotillo

• Article
  30 July 2022 | Open Access

  Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure

  ChREBP is a glucose-responsive transcription factor, which regulates glucose-mediated proliferation and cell death in pancreatic β-cells. Here the authors show that the acute feed forward induction of ChREBPβ is required for adaptive β-cell expansion, that chronic overexpression of ChREBPβ is toxic to β-cells, and offer mitigation strategies

  • Liora S. Katz
  • , Gabriel Brill
  •  & Donald K. Scott

• Article
  27 July 2022 | Open Access

  Targeting transcription in heart failure via CDK7/12/13 inhibition

  In this study, Hsu et al. show that inhibition of CDK7/12/13 attenuates maladaptive transcriptional activation in cultured cardiomyocytes and a mouse model of heart failure, suggesting that targeting the transcription machinery might be a therapeutic approach to treat heart failure with reduced ejection fraction.

  • Austin Hsu
  • , Qiming Duan
  •  & Saptarsi M. Haldar

• Article
  25 July 2022 | Open Access

  Light-activated mitochondrial fission through optogenetic control of mitochondria-lysosome contacts

  Existing methods can lack spatiotemporal accuracy to manipulate dynamic mitochondrial behaviour in live cells. Here the authors report an optogenetic method to control mitochondria-lysosome contacts and induce mitochondrial fission; they use photoactivatable dimerizers including CRY2/CIB and SspB/iLID.

  • Kangqiang Qiu
  • , Weiwei Zou
  •  & Jiajie Diao

• Article
  25 July 2022 | Open Access

  Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ

  Whether amino acids act on cellular insulin signaling remains unclear. Here, the authors find that phenylalanine modifies insulin receptor beta (IRβ) and inactivates insulin signaling and glucose uptake and positively correlated with T2D onset.

  • Qian Zhou
  • , Wan-Wan Sun
  •  & Shi-Min Zhao

• Article
  12 July 2022 | Open Access

  Malaria parasite heme biosynthesis promotes and griseofulvin protects against cerebral malaria in mice

  Malaria parasite heme pathway is non-essential for blood stages, but essential for mosquito and liver stages. Here, the authors show that heme pathway promotes cerebral pathogenesis by enhancing hemozoin formation and that targeting it with griseofulvin inhibits cerebral malaria in mice.

  • Manjunatha Chandana
  • , Aditya Anand
  •  & Viswanathan Arun Nagaraj

• Article
  04 July 2022 | Open Access

  Sex differences in heart mitochondria regulate diastolic dysfunction

  In this paper, the authors show that sex differences in mitochondrial DNA levels and function in the heart contribute to sex biases in functions relevant to heart failure, identifying Acsl6 as a mitochondrial sex-biased regulator of diastolic function.

  • Yang Cao
  • , Laurent Vergnes
  •  & Aldons J. Lusis

• Article
  01 July 2022 | Open Access

  T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice

  Cholesterol efflux is mediated by specific transporters in T cells. Here the authors show that when the ABCA1/ABCG1 cholesterol transporters are absent, peripheral T cell numbers are reduced but activation increased with a premature aging phenotype of T cell senescence and apoptosis in middle aged Ldlr^−/− mice.

  • Venetia Bazioti
  • , Anouk M. La Rose
  •  & Marit Westerterp

• Article
  29 June 2022 | Open Access

  WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage

  Cancer develops in Wiskott-Aldrich syndrome (WAS). Here the authors identify a role for WAS-protein (WASp) in the DNA stress-resolution pathway by promoting the function of Replication Protein A at replication forks after DNA damage.

  • Seong-Su Han
  • , Kuo-Kuang Wen
  •  & Yatin M. Vyas