Mass spectrometry articles from across Nature Portfolio

Mass spectrometry is an analytical technique that uses an instrument called a mass spectrometer to measure the mass-to-charge ratios of molecular ions. Molecules fragment within the mass spectrometer to produce a mass spectrum, which can be interpreted to determine the identity of the molecules in the sample.

Latest Research and Reviews

Research
22 May 2023 | Open Access

Determining the gas-phase structures of α-helical peptides from shape, microsolvation, and intramolecular distance data

It remains challenging to gauge the gas-phase structure of biomolecular ions and assess to what extent native-like structures are maintained. Here, the authors utilize Förster resonance energy transfer and ion mobility spectrometry for more stringent structural characterization of biomolecular ions.
- Ri Wu
- , Jonas B. Metternich
- & Renato Zenobi
Nature Communications 14, 2913
Research
19 May 2023 | Open Access

Using mass spectrometry imaging to map fluxes quantitatively in the tumor ecosystem

Isotopologue spectral analysis was originally designed to assess metabolic fluxes from bulk samples. Here, the authors adapted this approach to infer fluxes from discrete regions in tissue by using mass spectrometry imaging, showing increased fatty acid synthesis flux in brain tumors of mice.
- Michaela Schwaiger-Haber
- , Ethan Stancliffe
- & Gary J. Patti
Nature Communications 14, 2876
Research
17 May 2023 | Open Access

Elucidating the molecular programming of a nonlinear non-ribosomal peptide synthetase responsible for fungal siderophore biosynthesis

Fungal siderophores are biosynthesised by nonribosomal peptide synthetases (NRPSs) with highly unusual domain architectures. Here, the authors characterise cryptic programming events occurring within SidC NRPS, responsible for ferricrocin biosynthesis in Aspergillus nidulans.
- Matthew Jenner
- , Yang Hai
- & Yi Tang
Nature Communications 14, 2832
Research
10 May 2023 | Open Access

Spatially resolved multi-omics highlights cell-specific metabolic remodeling and interactions in gastric cancer

The spatial signature of metabolic remodeling in tumours remains to be explored. Here, the integration of mass spectrometry imaging-based spatial metabolomics and lipidomics with microarray-based spatial transcriptomics allows the visualisation of metabolic heterogeneity in gastric cancer.
- Chenglong Sun
- , Anqiang Wang
- & Jiuming He
Nature Communications 14, 2692
Research
09 May 2023 | Open Access

Evaluation of extraction methods for untargeted metabolomic studies for future applications in zebrafish larvae infection models
- Philip Schippers
- , Sari Rasheed
- & Markus R. Meyer
Scientific Reports 13, 7489
Research
06 May 2023 | Open Access

Mitochondrial citrate metabolism and efflux regulate BeWo differentiation
- Renee M. Mahr
- , Snehalata Jena
- & Sarah A. Wernimont
Scientific Reports 13, 7387

All Research & Reviews

News and Comment

Research Highlights | 11 May 2023

Crosslinking mass spectrometry data bolster protein structure prediction
- Arunima Singh
Nature Methods 20, 633
Research Highlights | 28 April 2023

Matchmaking in the chambers
- Grant Miura
Nature Chemical Biology 19, 537
News & Views | 20 April 2023

Laser cooling unlocks metal tracer

Atom trap trace analysis has emerged as a powerful technique for detecting trace radioisotopes of noble gases. The successful application of the method to a calcium isotope now opens the possibility of extension to other metal isotopes.
- Rohan D. Glover
Nature Physics, 1-2
News & Views | 13 April 2023

Accurate determination of molecular formulae using tandem mass spectrometry

We highlight the BUDDY software, which was developed to accurately determine the molecular formulae of unknown chemicals in mass spectrometry data. BUDDY is a bottom-up approach that shows superior annotation performance on reference spectra and experimental datasets. Incorporation of global peak annotation could enable BUDDY to refine formula annotations and reveal feature interrelationships.

Nature Methods, 1-2
News & Views | 03 April 2023

Extending the sensitivity, consistency and depth of single-cell proteomics

Simultaneous maximization of sensitivity, data completeness and throughput in mass-spectrometry proteomics often necessitates trade-offs. To mitigate these trade-offs, we introduce a prioritization algorithm that achieves high sensitivity and data completeness while maximizing throughput. With prioritized single-cell proteomics (pSCoPE), we consistently and accurately quantify proteins and their post-translational modifications in single macrophages and link them to endocytic activity.

Nature Methods 20, 649-650
Research Highlights | 27 March 2023

One, two, three, four, five!
- Benjamin Martindale
Nature Catalysis 6, 215

All News & Comment

Mass spectrometry articles from across Nature Portfolio

Latest Research and Reviews

Determining the gas-phase structures of α-helical peptides from shape, microsolvation, and intramolecular distance data

Using mass spectrometry imaging to map fluxes quantitatively in the tumor ecosystem

Elucidating the molecular programming of a nonlinear non-ribosomal peptide synthetase responsible for fungal siderophore biosynthesis

Spatially resolved multi-omics highlights cell-specific metabolic remodeling and interactions in gastric cancer

Evaluation of extraction methods for untargeted metabolomic studies for future applications in zebrafish larvae infection models

Mitochondrial citrate metabolism and efflux regulate BeWo differentiation

News and Comment

Crosslinking mass spectrometry data bolster protein structure prediction

Matchmaking in the chambers

Laser cooling unlocks metal tracer

Accurate determination of molecular formulae using tandem mass spectrometry

Extending the sensitivity, consistency and depth of single-cell proteomics

One, two, three, four, five!

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