Mass spectrometry

Mass spectrometry is an analytical technique that uses an instrument called a mass spectrometer to measure the mass-to-charge ratios of molecular ions. Molecules fragment within the mass spectrometer to produce a mass spectrum, which can be interpreted to determine the identity of the molecules in the sample.

Latest Research and Reviews

  • Reviews |

    Tandem mass spectrometry can reveal metabolite positional labeling and improve the performance of metabolic flux analysis as long as daughter ions are carefully inspected. When calculating the fluxes, the tandem mass isotopomer distributions as well as the mass isotopomer distributions of parent and daughter ions should all be used to constrain the fluxes in order to achieve the best performance.

    • Yujue Wang
    • , Sheng Hui
    • , Fredric E. Wondisford
    •  & Xiaoyang Su
  • Research |

    Native ion mobility mass spectrometry reveals two isoforms of the two-pore domain K+ channel K2P4.1 have distinct binding preferences for lipids and show a relationship between the strength of individual lipid binding events and channel activity.

    • Samantha Schrecke
    • , Yun Zhu
    • , Jacob W. McCabe
    • , Mariah Bartz
    • , Charles Packianathan
    • , Minglei Zhao
    • , Ming Zhou
    • , David Russell
    •  & Arthur Laganowsky
  • Research
    | Open Access

    Herpesviruses code for conserved protein kinases (CHPKs) that exert several regulatory functions by interacting with cellular factors. Here, the authors use affinity purification mass spectrometry (AP–MS) to identify differential interaction partners of CHPKs from seven different human herpesviruses, finding Cyclin A and associated factors as a specific signature of β-herpesvirus kinases.

    • Boris Bogdanow
    • , Max Schmidt
    • , Henry Weisbach
    • , Iris Gruska
    • , Barbara Vetter
    • , Koshi Imami
    • , Eleonore Ostermann
    • , Wolfram Brune
    • , Matthias Selbach
    • , Christian Hagemeier
    •  & Lüder Wiebusch
  • Research |

    Linke et al. use unbiased and quantitative techniques to directly link both known and unknown liver and plasma lipid moieties to specific genomic loci, as compiled in a public web resource, LipidGenie. LipidGenie aided in the identification of a new group of sex-specific phosphatidylcholines.

    • Vanessa Linke
    • , Katherine A. Overmyer
    • , Ian J. Miller
    • , Dain R. Brademan
    • , Paul D. Hutchins
    • , Edna A. Trujillo
    • , Thiru R. Reddy
    • , Jason D. Russell
    • , Emily M. Cushing
    • , Kathryn L. Schueler
    • , Donald S. Stapleton
    • , Mary E. Rabaglia
    • , Mark P. Keller
    • , Daniel M. Gatti
    • , Gregory R. Keele
    • , Duy Pham
    • , Karl W. Broman
    • , Gary A. Churchill
    • , Alan D. Attie
    •  & Joshua J. Coon
  • Research |

    The rare blood group Dantu is known to protect against severe malaria, and a mechanism is proposed here: Dantu red blood cells have a high membrane tension that prevents invasion by malaria parasites.

    • Silvia N. Kariuki
    • , Alejandro Marin-Menendez
    • , Viola Introini
    • , Benjamin J. Ravenhill
    • , Yen-Chun Lin
    • , Alex Macharia
    • , Johnstone Makale
    • , Metrine Tendwa
    • , Wilfred Nyamu
    • , Jurij Kotar
    • , Manuela Carrasquilla
    • , J. Alexandra Rowe
    • , Kirk Rockett
    • , Dominic Kwiatkowski
    • , Michael P. Weekes
    • , Pietro Cicuta
    • , Thomas N. Williams
    •  & Julian C. Rayner
    Nature 585, 579-583

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