Mammary stem cells articles from across Nature Portfolio

Mammary stem cells are multipotent adult stem cells that reside in the mammary gland, can self-renew by dividing and can differentiate into all specialised mammary epithelial cells. Mammary stem cells drive the development of the mammary gland during puberty and are responsible for its expansion during pregnancy.

Latest Research and Reviews

Research
02 May 2023 | Open Access

Macrophages maintain mammary stem cell activity and mammary homeostasis via TNF-α-PI3K-Cdk1/Cyclin B1 axis
- Yu Zhou
- , Zi Ye
- & Cheguo Cai
npj Regenerative Medicine 8, 23
Research
07 December 2022 | Open Access

Breast cancer prevention by short-term inhibition of TGFβ signaling

TGFβ signalling is reported to regulate hormone-responsive mammary epithelial progenitors that are associated with breast cancer risk. Here, the authors find that short-term TGFBR1 inhibition prevents tumour formation in rat breast cancer models and identify a TGFBR1 inhibition-responsive sub-population of mammary epithelial cells, which is associated with human breast cancer risk.
- Maša Alečković
- , Simona Cristea
- & Kornelia Polyak
Nature Communications 13, 7558
Research
28 November 2022 | Open Access

Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas

LATS1/2 kinases are reported to be tumour suppressors in many cancers. Here the authors show that conditional deletion of LATS1/2 in the mature mouse luminal mammary epithelium leads to luminal-basal plasticity and development of basal-like carcinomas.
- Joseph G. Kern
- , Andrew M. Tilston-Lunel
- & Xaralabos Varelas
Nature Communications 13, 7198
Research
12 July 2022 | Open Access

Ductal keratin 15⁺ luminal progenitors in normal breast exhibit a basal-like breast cancer transcriptomic signature
- Katharina Theresa Kohler
- , Nadine Goldhammer
- & Jiyoung Kim
npj Breast Cancer 8, 81
Research
12 April 2022 | Open Access

Evolution of gene expression signature in mammary gland stem cells from neonatal to old mice
- Xiaoling Huang
- , Yue Xu
- & Zuoren Yu
Cell Death & Disease 13, 335
Research
17 March 2022 | Open Access

Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency

Gpr125 has emerged as a specific marker of mammary stem cells and basal progenitors. Here they show that Gpr125 cells congregate at ductal tips during morphogenesis and amass at tumor margins, and that high Gpr125 predicts early tumor onset and poor outcome in basal breast cancer.
- Elena Spina
- , Julia Simundza
- & Pamela Cowin
Nature Communications 13, 1421

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News and Comment

Research Highlights | 06 June 2022

Mediat(or)ing adult stem cells by XIST

XIST loss causes partial gene reactivation at the inactive X chromosome, resulting in Mediator-dependent expansion of adult mammary stem cells and tumorigenesis.
- Eytan Zlotorynski
Nature Reviews Molecular Cell Biology 23, 447
News & Views | 14 February 2022

Mitochondrial efficiency directs cell fate

Mitochondria are asymmetrically distributed to the daughter cells according to their age. A study now identifies metabolic features associated with mitochondrial age that regulate cell fate decisions.
- Jessica Brooke Spinelli
- & Elma Zaganjor
Nature Cell Biology 24, 125-126
News & Views | 21 May 2018

Mammary lineage restriction in development

The establishment of the two distinct lineages that form the branched epithelial ductal tree of the mammary gland is a complex and essential developmental process. Two independent studies now describe the switch from multipotency to unipotency as an embryonic process and outline mechanisms of early lineage restriction.
- Philip Bland
- & Beatrice A. Howard
Nature Cell Biology 20, 637-639
News & Views | 31 May 2017

Reducing interferon'ce in stem cells

Little is known regarding how the interactions of stem cells with the immune system regulate their plasticity. A study now describes a mechanism by which normal breast and cancer stem cells utilize miR-199a to downregulate the corepressor LCOR and minimize responses to type I interferon.
- Alycia Gardner
- & Brian Ruffell
Nature Cell Biology 19, 597-599
Research Highlights | 24 September 2015

Different in the details
- Sarah Seton-Rogers
Nature Reviews Cancer 15, 574
Research Highlights | 23 April 2015

Sorting ageing mitochondria
- Kim Baumann
Nature Reviews Molecular Cell Biology 16, 267

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Mammary stem cells articles from across Nature Portfolio

Latest Research and Reviews

Macrophages maintain mammary stem cell activity and mammary homeostasis via TNF-α-PI3K-Cdk1/Cyclin B1 axis

Breast cancer prevention by short-term inhibition of TGFβ signaling

Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas

Ductal keratin 15⁺ luminal progenitors in normal breast exhibit a basal-like breast cancer transcriptomic signature

Evolution of gene expression signature in mammary gland stem cells from neonatal to old mice

Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency

News and Comment

Mediat(or)ing adult stem cells by XIST

Mitochondrial efficiency directs cell fate

Mammary lineage restriction in development

Reducing interferon'ce in stem cells

Different in the details

Sorting ageing mitochondria

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