Male factor infertility

Emerging evidence suggests that the seminal microbiome has implications for the reproductive health of men, their partner, and even the health of their offspring. In this Review, the authors describe the current evidence for a seminal microbiome and consider what the future holds for this field of research.

Male infertility is a multifactorial pathological condition, and its genetic landscape is highly complex. Here, Krausz and Riera-Escamilla describe our current understanding of the genetics of male infertility and the clinical implications of this knowledge.

In this Review, Lotti and Maggi discuss the correlations between sexual dysfunction and male infertility, focusing on the associations between reproductive, sexual, psychological, and general health.

Asthenozoospermia is a major cause of male infertility, and multiple morphological abnormalities of the flagella (MMAF) is a particularly severe form. Here, using whole-exome sequencing of 78 MMAF patients, the authors identify mutations in two WDR proteins, CFAP43 and CFAP44, and confirm that these proteins are required for flagellogenesis in mouse and Trypanosoma brucei.