Malaria

Definition

Malaria is a mosquito-borne disease that is caused by Plasmodium parasites. Patients with malaria experience flu-like symptoms and, in severe cases, the disease can progress to neurological disturbances, coma and death. Malaria is endemic in tropical and subtropical regions and causes up to one million deaths each year.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    Two recent studies provide new insights into the architecture, molecular mechanisms and function of the Plasmodium translocon of exported proteins (PTEX) complex and the core PTEX protein EXP2.

    • Ashley York
  • News and Views |

    The multiprotein complex PTEX enables malaria-causing parasites to survive inside red blood cells. Studies reveal how PTEX assembles, and identify a function for one of the complex’s proteins, EXP2.

    • Tania F. de Koning-Ward
    Nature 561, 41–43
  • News and Views |

    Plasmodium parasites possess a unique PEXEL sorting pathway to deliver secretory proteins into the host cells in which they reside. A new study shows the existence of independent sorting/entry complexes to detect and deliver PEXEL proteins into the parasite endoplasmic reticulum.

    • Martin R. Pool
    •  & Ilaria Russo
    Nature Microbiology 3, 969–970
  • Editorial |

    Workers on the front line of the battle against the disease are too often overlooked as scientists and funders plot how to defeat malaria.

    Nature 559, 443