Malaria articles from across Nature Portfolio

Malaria is a mosquito-borne disease that is caused by Plasmodium parasites. Patients with malaria experience flu-like symptoms and, in severe cases, the disease can progress to neurological disturbances, coma and death. Malaria is endemic in tropical and subtropical regions and causes up to one million deaths each year.

Latest Research and Reviews

Research
20 March 2023 | Open Access

Malaria hotspots and climate change trends in the hyper-endemic malaria settings of Mizoram along the India–Bangladesh borders
- Pachuau Lalmalsawma
- , K. Balasubramani
- & Praveen Balabaskaran Nina
Scientific Reports 13, 4538
Research
16 March 2023 | Open Access

Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation

Drug resistance to current antimalarials is rising and new drugs and targets are urgently needed. Here the authors identify Plasmodium falciparum acyl-CoA synthetase 10 as a new target whose inhibition leads to a decrease in triacylglycerols.
- Selina Bopp
- , Charisse Flerida A. Pasaje
- & Dyann F. Wirth
Nature Communications 14, 1455
Research
13 March 2023 | Open Access

Non-falciparum malaria infection and IgG seroprevalence among children under 15 years in Nigeria, 2018

Nigeria has a high burden of malaria which mostly results from Plasmodium falciparum infection, but other species are also endemic. Here, the authors estimate the prevalence of active infection and previous exposure to P malariae, P ovale, and P vivax in children in Nigeria in 2018 and determine risk factors.
- Camelia Herman
- , Colleen M. Leonard
- & Eric Rogier
Nature Communications 14, 1360
Research
23 February 2023 | Open Access

Assessment of the drugability of initial malaria infection through miniaturized sporozoite assays and high-throughput screening

A high-throughput screening pipeline tests the feasibility of targeting the sporozoite stage of P. falciparum through chemical interventions and identifies gramicidin as a potential sporontocidal agent.
- Marie Miglianico
- , Judith M. Bolscher
- & Koen J. Dechering
Communications Biology 6, 216
Research
21 February 2023 | Open Access

A non-canonical sensing pathway mediates Plasmodium adaptation to amino acid deficiency

The nek4, eIK1, and eIK2 sensor kinases play a key role in Plasmodium amino acid sensing, enabling these parasites to fine-tune replication and development in response to amino acid availability.
- Inês M. Marreiros
- , Sofia Marques
- & Maria M. Mota
Communications Biology 6, 205
Research
18 February 2023 | Open Access

Design of a stabilized non-glycosylated Pfs48/45 antigen enables a potent malaria transmission-blocking nanoparticle vaccine
- Thayne H. Dickey
- , Richi Gupta
- & Niraj H. Tolia
npj Vaccines 8, 20

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News and Comment

Research Highlights | 10 February 2023

Natural killer cells adapt to malaria exposures
- Yvonne Bordon
Nature Reviews Immunology 23, 139
Comments & Opinion | 19 December 2022

The slow roll-out of the world’s first malaria vaccine

After 30 years of development, there is finally a vaccine for malaria. But it might take years to get it to the children who need it.
- Cassandra Willyard
Nature 612, S48-S49
News & Views | 07 December 2022

How a malaria parasite becomes a male

Organisms use various strategies for sex determination. The non-genetic mechanism in the malaria-causing parasite Plasmodium falciparum, involving a male-specific factor, has now been revealed.
- Elisabet Tintó-Font
- & Alfred Cortés
Nature 612, 408-409
News & Views | 09 November 2022

Host–parasite dynamics in the liver stage of malaria

Gene expression was assessed in individual liver cells from mice that were infected with the rodent-specific form of the malaria parasite. This revealed that infections of cells in the inner zones of the lobule units that make up the liver are more likely to succeed than are infections in the outer zones.

Nature
News | 02 November 2022

Resistant mosquito threatens Africa’s fight against malaria

Study links invasive Anopheles stephensi to a recent outbreak in Ethiopia, worrying scientists.
- Max Kozlov
Nature
Editorial | 05 October 2022

Laggard rich countries risk slowing the fight against AIDS, malaria and TB

The United Kingdom and Italy need to renew their commitments to banish these major infectious killers from the world.

Nature 610, 8

All News & Comment

Malaria articles from across Nature Portfolio

Latest Research and Reviews

Malaria hotspots and climate change trends in the hyper-endemic malaria settings of Mizoram along the India–Bangladesh borders

Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation

Non-falciparum malaria infection and IgG seroprevalence among children under 15 years in Nigeria, 2018

Assessment of the drugability of initial malaria infection through miniaturized sporozoite assays and high-throughput screening

A non-canonical sensing pathway mediates Plasmodium adaptation to amino acid deficiency

Design of a stabilized non-glycosylated Pfs48/45 antigen enables a potent malaria transmission-blocking nanoparticle vaccine

News and Comment

Natural killer cells adapt to malaria exposures

The slow roll-out of the world’s first malaria vaccine

How a malaria parasite becomes a male

Host–parasite dynamics in the liver stage of malaria

Resistant mosquito threatens Africa’s fight against malaria

Laggard rich countries risk slowing the fight against AIDS, malaria and TB

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