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| Open AccessMetal ions and sugar puckering balance single-molecule kinetic heterogeneity in RNA and DNA tertiary contacts
Mobile group II introns function as ribozymes to splice and reinsert themselves into DNA, thereby colonizing new genomic regions. Here the authors use single-molecule FRET and molecular dynamics simulations to reveal a structural link between metal ion induced kinetic heterogeneity and the sugar puckers at the exon-intron binding interface.
- Fabio D. Steffen
- , Mokrane Khier
- & Roland K. O. Sigel
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Article
| Open AccessMagnesium uptake by connecting fluid-phase endocytosis to an intracellular inorganic cation filter
Metal bioavailability is frequently limited by sequestering agents which makes them inaccessible to cells. Here the authors show that cells can increase Mg2+ uptake via fluid phase endocytosis and accumulate this metal in their vacuole loaded with polyphosphate, and later can be exported to the cytosol.
- Sandra H. Klompmaker
- , Kid Kohl
- & Andreas Mayer
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Article
| Open AccessTRPM7 is essential for Mg2+ homeostasis in mammals
Magnesium is an essential element of the diet and is a cofactor for many enzymes. In this study, the channel kinase TRPM7 is shown to be essential for magnesium homeostasis, and heterozygous mice lacking the kinase domain show a defect in absorption of magnesium from the diet.
- Lillia V. Ryazanova
- , Lusliany J. Rondon
- & Alexey G. Ryazanov