Macular degeneration articles from across Nature Portfolio

Macular degeneration usually refers to the age-related degenerative changes in the retina that can result in loss of central vision. It is caused by abnormal blood vessel growth (a condition referred to as 'wet' macular degeneration) or atrophy and accumulation of debris ('dry' macular degeneration), both of which damage the macula.

Latest Research and Reviews

Research
30 May 2023 | Open Access

Antibody blockade of Jagged1 attenuates choroidal neovascularization

Current treatment for neovascular age-related macular degeneration (nAMD) does not help all patients. Here, the authors show that using antibodies to block Jagged1 reduces disease burden in a model of nAMD, which could enable new treatment options.
- Torleif Tollefsrud Gjølberg
- , Jonas Aakre Wik
- & Eirik Sundlisæter
Nature Communications 14, 3109
Research
24 May 2023 | Open Access

Multimodal imaging of laser-induced choroidal neovascularization in pigmented rabbits
- Van Phuc Nguyen
- , Jessica Henry
- & Yannis M. Paulus
Scientific Reports 13, 8396
Research
22 May 2023 | Open Access

Deep learning to detect macular atrophy in wet age-related macular degeneration using optical coherence tomography
- Wei Wei
- , Joshua Southern
- & Kirill Veselkov
Scientific Reports 13, 8296
Research
20 May 2023 | Open Access

Klotho prevents transforming growth factor-β2-induced senescent-like morphological changes in the retinal pigment epithelium
- Ha Young Jang
- , Soo-Jin Kim
- & Jeong Hun Kim
Cell Death & Disease 14, 334
Research
19 May 2023 | Open Access

Accurate drusen segmentation in optical coherence tomography via order-constrained regression of retinal layer heights
- Olivier Morelle
- , Maximilian W. M. Wintergerst
- & Thomas Schultz
Scientific Reports 13, 8162
Research
12 May 2023 | Open Access

The real-world efficacy and safety of faricimab in neovascular age-related macular degeneration: the TRUCKEE study – 6 month results
- Arshad M. Khanani
- , Aamir A. Aziz
- & Carl J. Danzig
Eye, 1-8

All Research & Reviews

News and Comment

Editorial
29 September 2022 | Open Access

Do patients with unilateral macular neovascularization type 3 need AREDS supplements to slow the progression to advanced age-related macular degeneration?
- Bilal Haj Najeeb
- & Ursula Schmidt-Erfurth
Eye, 1-3
Correspondence | 17 September 2022

Structural integrity of retinal pigment epithelial cells in eyes with age-related scattered hypofluorescent spots on late phase indocyanine green angiography (ASHS-LIA)
- Joanne Li
- , Nancy Aguilera
- & Johnny Tam
Eye 37, 377-378
Comments & Opinion
28 June 2022 | Open Access

Health technology assessment of new retinal treatments; the need to capture healthcare capacity issues
- Richard Gale
- , Oliver Cox
- & Usha Chakravarthy
Eye 36, 2236-2238
Editorial | 25 June 2022

15 years of anti-VEGF treatment for nAMD: success or failure or something in between?
- Usha Chakravarthy
- , Beatriz G. Armendariz
- & Sascha Fauser
Eye 36, 2232-2233
Comments & Opinion | 24 February 2021

The need to investigate hyperuricemia as a factor in the onset of age-related macular degeneration
- Hung-Liang Pai
- , Han-Hsin Chang
- & David Pei-Cheng Lin
Eye 35, 1804-1807
News & Views | 12 February 2021

‘Hit and run’ therapy averts macular degeneration

Subretinal delivery of lentiviruses bearing Cas9 mRNA and a guide RNA targeting the Vegfa gene reduces the development of choroidal neovascularization in a mouse model of wet age-related macular degeneration.
- Felix Bubeck
- & Dirk Grimm
Nature Biomedical Engineering 5, 132-133

All News & Comment

Macular degeneration articles from across Nature Portfolio

Latest Research and Reviews

Antibody blockade of Jagged1 attenuates choroidal neovascularization

Multimodal imaging of laser-induced choroidal neovascularization in pigmented rabbits

Deep learning to detect macular atrophy in wet age-related macular degeneration using optical coherence tomography

Klotho prevents transforming growth factor-β2-induced senescent-like morphological changes in the retinal pigment epithelium

Accurate drusen segmentation in optical coherence tomography via order-constrained regression of retinal layer heights

The real-world efficacy and safety of faricimab in neovascular age-related macular degeneration: the TRUCKEE study – 6 month results

News and Comment

Do patients with unilateral macular neovascularization type 3 need AREDS supplements to slow the progression to advanced age-related macular degeneration?

Structural integrity of retinal pigment epithelial cells in eyes with age-related scattered hypofluorescent spots on late phase indocyanine green angiography (ASHS-LIA)

Health technology assessment of new retinal treatments; the need to capture healthcare capacity issues

15 years of anti-VEGF treatment for nAMD: success or failure or something in between?

The need to investigate hyperuricemia as a factor in the onset of age-related macular degeneration

‘Hit and run’ therapy averts macular degeneration

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