Lymphoproliferative disorders

  • Article
    | Open Access

    Loss of TET proteins in immune cell populations is known to result in immunopathology. Here the authors show that deficiency of Tet2 and Tet3 proteins, specifically in the CD4+ FoxP3+ Treg lineage, results in a dominant pathology in which ex-Treg cells and bystander T cells gain aberrant effector function.

    • Xiaojing Yue
    • , Chan-Wang J. Lio
    •  & Anjana Rao