Lymphoid tissues articles from across Nature Portfolio

Lymphoid tissues are organized structures that support immune responses. The bone marrow and thymus are primary lymphoid tissues and the sites of lymphocyte development. The lymph nodes, spleen, tonsils and Peyer’s patches are examples of secondary lymphoid tissue. Chronic inflammation can lead to the development of tertiary lymphoid tissue.

Latest Research and Reviews

Research
13 March 2023 | Open Access

Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung allograft acceptance in mice

IL-2/anti-IL-2 antibody complexes have been shown to facilitate the process of graft acceptance in transplantation. Here the authors use a mouse allograft model to show that IL-2 complexes promote graft acceptance and formation of inducible lymphoid structures containing Treg cells in transplanted lungs.
- Yoshito Yamada
- , Tuan Thanh Nguyen
- & Onur Boyman
Nature Communications 14, 1383
Research
03 March 2023 | Open Access

Fibroblastic reticular cells in lymph node potentiate white adipose tissue beiging through neuro-immune crosstalk in male mice

Beiging and thermogenesis in white adipose tissue (WAT) is an important adaptive response to cold exposure, but how the brain senses cold and subsequently induces beiging remains unclear. Here, the authors show that sympathetic nerves stimulate lymph nodes to release IL-33, thereby mediating cold-induced beiging of WAT.
- Lai Yee Cheong
- , Baile Wang
- & Aimin Xu
Nature Communications 14, 1213
Reviews
09 February 2023 | Open Access

Regulatory T cells (Tregs) in liver fibrosis
- Ke-jia Wu
- , Qu-fei Qian
- & Yun-jie Lu
Cell Death Discovery 9, 53
Research
30 January 2023 | Open Access

Influence of circadian clocks on adaptive immunity and vaccination responses

Circadian rhythms have been shown to influence immune responses, but it is unclear whether this influences responses to vaccines. Here the authors show that dendritic cells migrate in a circadian rhythm meaning that interactions with T cells are altered leading to differential vaccine responses.
- Louise Madeleine Ince
- , Coline Barnoud
- & Christoph Scheiermann
Nature Communications 14, 476
Research
21 December 2022 | Open Access

Single cell multi-omic reference atlases of non-human primate immune tissues reveals CD102 as a biomarker for long-lived plasma cells

CD102 is an enriched biomarker for long-lived plasma cells in non-human primates (NHPs) and is conserved across NHPs, humans, and mice.
- Ryan P. Staupe
- , Kenneth E. Lodge
- & Nicole L. Sullivan
Communications Biology 5, 1399
Research | 19 December 2022

Adaptive immune responses to SARS-CoV-2 persist in the pharyngeal lymphoid tissue of children

Manthiram and colleagues analyze the peripheral blood, tonsils and adenoids in children undergoing tonsillectomy or adenoidectomy and find evidence of continued tissue-specific immunity to SARS-CoV-2 and viral RNA persistence weeks to months after acute infection.
- Qin Xu
- , Pedro Milanez-Almeida
- & Kalpana Manthiram
Nature Immunology 24, 186-199

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News and Comment

Research Highlights | 23 March 2023

Modulating bone marrow niches
- Laurie A. Dempsey
Nature Immunology, 1
Research Highlights | 10 February 2023

ENTERing the world of immune cells
- Madhura Mukhopadhyay
Nature Methods 20, 177
Comments & Opinion | 12 January 2023

Immunomechanics

Mechanoimmunology methods help dissect the mechanical forces within the immune system.
- Madhura Mukhopadhyay
Nature Methods 20, 35
Research Highlights | 08 December 2022

Pollution impairs lung defences with age

Accumulation of inhaled carbon particulates in lung-draining lymph nodes with age impairs respiratory immunity.
- Kirsty Minton
Nature Reviews Immunology 23, 5
News & Views | 01 December 2022

Effect of air pollution on the human immune system

Inhaled particulates from environmental pollutants accumulate in macrophages in lung-associated lymph nodes over years, compromising immune surveillance via direct effects on immune cell function and lymphoid architecture. These findings reveal the importance of improved air quality to preserve immune health against current and emerging pathogens.

Nature Medicine 28, 2482-2483
Research Highlights | 31 October 2022

Dynamics of antigen retention by follicular dendritic cells

A preprint by Martinez-Riano et al. evaluates the dynamics of antigen retention by follicular dendritic cells (FDCs) in germinal centres, showing that immune complexes accumulate in the centre of the FDC network.
- Nicolas Ruffin
- & Ester Gea-Mallorquí
Nature Reviews Immunology 22, 715

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Lymphoid tissues articles from across Nature Portfolio

Latest Research and Reviews

Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung allograft acceptance in mice

Fibroblastic reticular cells in lymph node potentiate white adipose tissue beiging through neuro-immune crosstalk in male mice

Regulatory T cells (Tregs) in liver fibrosis

Influence of circadian clocks on adaptive immunity and vaccination responses

Single cell multi-omic reference atlases of non-human primate immune tissues reveals CD102 as a biomarker for long-lived plasma cells

Adaptive immune responses to SARS-CoV-2 persist in the pharyngeal lymphoid tissue of children

News and Comment

Modulating bone marrow niches

ENTERing the world of immune cells

Immunomechanics

Pollution impairs lung defences with age

Effect of air pollution on the human immune system

Dynamics of antigen retention by follicular dendritic cells

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Lymphoid tissues articles from across Nature Portfolio

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