Lymphatic vessels articles from across Nature Portfolio

Lymphatic vessels are thin, tubular structures with valve-like openings that collect lymph from the tissues and transport it throughout the body. Afferent lymphatics deliver lymph from tissues into lymph nodes, whereas efferent lymphatics bring the filtered lymph away from the lymph node. Lymphocytes also circulate via the lymphatic vessels.

Latest Research and Reviews

Research
30 November 2022 | Open Access

Deciphering the heterogeneity of the Lyve1⁺ perivascular macrophages in the mouse brain

Perivascular macrophages (pvMs) are important for brain drainage and immune regulation. Here the authors analyse various reporter mouse strains for finer mapping of pvM subsets and lineage differentiation, and propose CX3CR1negative and CD45low as additional markers of intermediate pvMs for studying this heterogenous population.
- C. Siret
- , M. van Lessen
- & S. A. van de Pavert
Nature Communications 13, 7366
Reviews | 03 November 2022

Asplenia and spleen hypofunction

Asplenia and hyposplenism can have multiple and complex causes and lead to morbidity and mortality, especially owing to overwhelming post-splenectomy infections. In this Primer, Lenti and colleagues review epidemiology, pathophysiology, diagnosis and management of these conditions, and discuss patient quality of life and future strategies.
- Marco Vincenzo Lenti
- , Sarah Luu
- & Antonio Di Sabatino
Nature Reviews Disease Primers 8, 71
Research
26 July 2022 | Open Access

Persistent popliteal lymphatic muscle cell coverage defects despite amelioration of arthritis and recovery of popliteal lymphatic vessel function in TNF-Tg mice following anti-TNF therapy
- H. Mark Kenney
- , Yue Peng
- & Edward M. Schwarz
Scientific Reports 12, 12751
Research | 28 March 2022

Neuroinflammation creates an immune regulatory niche at the meningeal lymphatic vasculature near the cribriform plate

Fabry and colleagues show that cribriform plate-resident lymphatic endothelial cells respond to neuroinflammatory signals by inducing functional changes that enhance antigen capture and presentation from the cerebrospinal fluid and promote leukocyte interactions within the central nervous system.
- Martin Hsu
- , Collin Laaker
- & Zsuzsanna Fabry
Nature Immunology 23, 581-593
Research
23 March 2022 | Open Access

Lung lymphatic thrombosis and dysfunction caused by cigarette smoke exposure precedes emphysema in mice
- Barbara D. Summers
- , Kihwan Kim
- & Hasina Outtz Reed
Scientific Reports 12, 5012
Research
18 October 2021 | Open Access

Circadian clocks guide dendritic cells into skin lymphatics

Scheiermann and colleagues show that circadian clocks control the infiltration of dendritic cells into skin lymphatics in mice and humans, with a peak migration to the lymph nodes during the rest phase.
- Stephan J. Holtkamp
- , Louise M. Ince
- & Christoph Scheiermann
Nature Immunology 22, 1375-1381

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News and Comment

News & Views | 28 March 2022

Retention of immune cells in cribriform lymphatics is induced by neuroinflammation

Cribriform plate-resident lymphatic endothelial cells respond to neuroinflammatory signals by inducing functional changes that enhance the capture and presentation of antigens from the cerebrospinal fluid and promote leukocyte interactions within the brain-draining lymphatics.

Nature Immunology 23, 483-484
Research Highlights | 24 September 2020

Meningeal lymphatic flow slows after mild traumatic brain injury
- Sarah Lemprière
Nature Reviews Neurology 16, 600
Research Highlights | 17 April 2019

Distinct S1PR roles
- Laurie A. Dempsey
Nature Immunology 20, 517
Research Highlights | 06 December 2018

Immunosuppressive lymphatics

Lane et al. have shown that interferon-γ (IFNγ)-mediated activation of the lymphatic vasculature, as a non-haematopoietic component of the tumour stroma, serves to limit local CD8⁺ T cell accumulation in melanoma in mice as a mechanism of immune suppression.
- Anna Dart
Nature Reviews Cancer 19, 6-7
Research Highlights | 21 August 2018

Brain lymphatic (dys)function
- Zoltan Fehervari
Nature Immunology 19, 901
Research Highlights | 24 July 2018

Cardiac lymphatics mediate the resolution of inflammation
- Alexandra Le Bras
Nature Reviews Cardiology 15, 583

All News & Comment

Lymphatic vessels articles from across Nature Portfolio

Latest Research and Reviews

Deciphering the heterogeneity of the Lyve1⁺ perivascular macrophages in the mouse brain

Asplenia and spleen hypofunction

Persistent popliteal lymphatic muscle cell coverage defects despite amelioration of arthritis and recovery of popliteal lymphatic vessel function in TNF-Tg mice following anti-TNF therapy

Neuroinflammation creates an immune regulatory niche at the meningeal lymphatic vasculature near the cribriform plate

Lung lymphatic thrombosis and dysfunction caused by cigarette smoke exposure precedes emphysema in mice

Circadian clocks guide dendritic cells into skin lymphatics

News and Comment

Retention of immune cells in cribriform lymphatics is induced by neuroinflammation

Meningeal lymphatic flow slows after mild traumatic brain injury

Distinct S1PR roles

Immunosuppressive lymphatics

Brain lymphatic (dys)function

Cardiac lymphatics mediate the resolution of inflammation

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