Lymphangiogenesis articles from across Nature Portfolio

Specialized endothelial cells within certain embryonic blood vessels can generate hematopoietic cells. A recent study reveals blood-forming capacity also within embryonic lymphatic endothelium, which is suppressed during normal development by the lymphatic endothelial fate-determining transcription factor PROX1.

Cribriform plate-resident lymphatic endothelial cells respond to neuroinflammatory signals by inducing functional changes that enhance the capture and presentation of antigens from the cerebrospinal fluid and promote leukocyte interactions within the brain-draining lymphatics.

How do we measure the impact of scientific research? A new study discusses the current publication culture, diverse animal models that are commonly used in cardiovascular studies, the comparison between basic and clinical research paths, and the role of authors and reviewers in bringing these two paths together.

How lymphatic vessels arise from veins is still poorly understood. A study reports the discovery of a ribosome biogenesis regulator Ddx21 as a previously unappreciated specific factor that is important for the first steps of lymphatic but not blood vessel development. The finding may lead to better strategies to selectively target lymphangiogenesis.

An article in the Proceedings of the National Academy of Sciences USA reports the engineering of lymphatic vessels in collagen matrices.

Tissue-resident macrophages form direct interactions with lymphatic endothelial cells and regulate the growth and sprouting of lymphatic vessels during development of the mammalian cardiac vasculature.