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Generation of specialized blood vessels via lymphatic transdifferentiation
A study of zebrafish identifies an innate mechanism of blood vessel formation through the transdifferentiation of lymphatic endothelial cells, and provides in vivo evidence for a link between cell ontogeny and functionality in endothelial cells.
- Rudra N. Das
- , Yaara Tevet
- & Karina Yaniv
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Lymphoangiocrine signals promote cardiac growth and repair
Lymphatic endothelium secretes factors needed for heart growth and repair such as RELN, which helps with heart regeneration and cardioprotection after myocardial infarction.
- Xiaolei Liu
- , Ester De la Cruz
- & Guillermo Oliver
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Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid
Clearance of macromolecules from the cerebrospinal fluid in mice takes place via meningeal lymphatic vessels at the base of the skull; both drainage and the integrity of these vessels deteriorate with age.
- Ji Hoon Ahn
- , Hyunsoo Cho
- & Gou Young Koh
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Letter |
FGF-dependent metabolic control of vascular development
Fibroblast growth factor receptor (FGFR) signalling is a crucial regulator of endothelial metabolism and vascular development.
- Pengchun Yu
- , Kerstin Wilhelm
- & Michael Simons
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The role of fatty acid β-oxidation in lymphangiogenesis
The lymphangiogenic factor PROX1 transcriptionally upregulates CPT1A, a rate-controlling enzyme in fatty acid β-oxidation, and this co-regulates lymphatic endothelial cell differentiation by epigenetic control of lymphatic gene expression, demonstrating a role for metabolism in developmental biology.
- Brian W. Wong
- , Xingwu Wang
- & Peter Carmeliet
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Article |
Cardiac lymphatics are heterogeneous in origin and respond to injury
The lymphatic system is thought to be derived by transdifferentiation of venous endothelium; this study shows that the origin of cardiac lymphatics is in fact more heterogeneous, including both venous and non-venous origins and that lymphangiogenesis occurs in the adult heart following myocardial infarction and can be enhanced to improve heart function.
- Linda Klotz
- , Sophie Norman
- & Paul R. Riley
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Article |
Lymphatic vessels arise from specialized angioblasts within a venous niche
The lymphatic endothelium is thought to arise entirely from trans-differentiation of the venous endothelium; a new mechanism of lymphatic vessel formation is identified in zebrafish, whereby the lymphatic vessels derive from specialized angioblasts within the floor of the cardinal vein.
- J. Nicenboim
- , G. Malkinson
- & K. Yaniv
A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature