Lymph node

Lymph nodes are small organs that are distributed throughout the body and drain lymph fluid from the tissues. Immune cells reside in lymph nodes and survey the lymph for signs of infection. If a tissue is infected, immune cells in the draining lymph node become activated and proliferate.

Latest Research and Reviews

  • Reviews |

    Nanoscale and microscale materials can be used as drug delivery vehicles to target specific lymph node-resident cell subtypes for immunotherapy. In this Review, the authors discuss the transport mechanisms to and from lymph nodes and how they can be explored for drug delivery.

    • Alex Schudel
    • , David M. Francis
    •  & Susan N. Thomas
  • Reviews |

    As a result of surgery or radiotherapy as treatment for cancer, functional components of the lymphatic system are partially removed or damaged, resulting in lymphoedema (accumulation of extracellular fluid in tissues). This Primer discusses this important adverse effect of cancer treatment that has substantial effects on the quality of life of patients.

    • Stanley G. Rockson
    • , Vaughan Keeley
    • , Sharon Kilbreath
    • , Andrzej Szuba
    •  & Anna Towers
  • Reviews |

    In this Review, the authors describe technologies for image-guided surgery for managing lymphatic metastases in prostate cancer. Refining these technologies should increase precision in the surgical recognition of positive lymph nodes and reduce the morbidity of pelvic lymph node dissection.

    • Fijs W. B. van Leeuwen
    • , Alexander Winter
    • , Henk G. van Der Poel
    • , Matthias Eiber
    • , Nazareno Suardi
    • , Markus Graefen
    • , Friedhelm Wawroschek
    •  & Tobias Maurer
  • Research | | open

    Induction of tolerance in the gut relies on immunomodulatory functions of mesenteric lymph nodes (mLN). Here the authors show that mLN stromal cells receive early microbiota imprinting in the neonatal phase to exhibit long-term, location-specific transcriptional programs for the induction of regulatory T cells and peripheral tolerance.

    • Joern Pezoldt
    • , Maria Pasztoi
    • , Mangge Zou
    • , Carolin Wiechers
    • , Michael Beckstette
    • , Guilhem R. Thierry
    • , Ehsan Vafadarnejad
    • , Stefan Floess
    • , Panagiota Arampatzi
    • , Manuela Buettner
    • , Janina Schweer
    • , Diana Fleissner
    • , Marius Vital
    • , Dietmar H. Pieper
    • , Marijana Basic
    • , Petra Dersch
    • , Till Strowig
    • , Mathias Hornef
    • , André Bleich
    • , Ulrike Bode
    • , Oliver Pabst
    • , Marc Bajénoff
    • , Antoine-Emmanuel Saliba
    •  & Jochen Huehn

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