Lymph node

Lymph nodes are small organs that are distributed throughout the body and drain lymph fluid from the tissues. Immune cells reside in lymph nodes and survey the lymph for signs of infection. If a tissue is infected, immune cells in the draining lymph node become activated and proliferate.

Latest Research and Reviews

  • Research
    | Open Access

    Migration and homing of B cells to lymph nodes are important for B cell functions, but their regulation is poorly understood. Here, the authors show that B cell-specific deletion of Cosmc results in decreased protein O-glycosylation, loss of B cell homing to both lymphoid and nonlymphoid organs, and altered transendothelial migration implicated in this loss.

    • Junwei Zeng
    • , Mahmoud Eljalby
    • , Rajindra P. Aryal
    • , Sylvain Lehoux
    • , Kathrin Stavenhagen
    • , Matthew R. Kudelka
    • , Yingchun Wang
    • , Jianmei Wang
    • , Tongzhong Ju
    • , Ulrich H. von Andrian
    •  & Richard D. Cummings
  • Research
    | Open Access

    The origin and diversity of blood vascular endothelial cells (BEC) in lymphoid tissues is unclear. Here, the authors profile murine BECs from peripheral lymph nodes by single cell analysis and identify subsets of cells specialised for immune cell recruitment and vascular homeostasis.

    • Kevin Brulois
    • , Anusha Rajaraman
    • , Agata Szade
    • , Sofia Nordling
    • , Ania Bogoslowski
    • , Denis Dermadi
    • , Milladur Rahman
    • , Helena Kiefel
    • , Edward O’Hara
    • , Jasper J. Koning
    • , Hiroto Kawashima
    • , Bin Zhou
    • , Dietmar Vestweber
    • , Kristy Red-Horse
    • , Reina E. Mebius
    • , Ralf H. Adams
    • , Paul Kubes
    • , Junliang Pan
    •  & Eugene C. Butcher
  • Research
    | Open Access

    Morphogens such as chemokines form gradients to direct graded responses and modulate cell behaviors. Here the authors show, using imaging and computer simulation, that the chemokine CXCL13 originated from follicular reticular cells in the lymph nodes forms both soluble and immobilized gradients to regulate B cell recruitment and migration.

    • Jason Cosgrove
    • , Mario Novkovic
    • , Stefan Albrecht
    • , Natalia B. Pikor
    • , Zhaoukun Zhou
    • , Lucas Onder
    • , Urs Mörbe
    • , Jovana Cupovic
    • , Helen Miller
    • , Kieran Alden
    • , Anne Thuery
    • , Peter O’Toole
    • , Rita Pinter
    • , Simon Jarrett
    • , Emily Taylor
    • , Daniel Venetz
    • , Manfred Heller
    • , Mariagrazia Uguccioni
    • , Daniel F. Legler
    • , Charles J. Lacey
    • , Andrew Coatesworth
    • , Wojciech G. Polak
    • , Tom Cupedo
    • , Bénedicte Manoury
    • , Marcus Thelen
    • , Jens V. Stein
    • , Marlene Wolf
    • , Mark C. Leake
    • , Jon Timmis
    • , Burkhard Ludewig
    •  & Mark C. Coles
  • Reviews |

    Turley and Krishnamurty review new insights into lymph node stromal cells, a heterogeneous cell population that serves distinct functions during development, in maintaining lymphocyte homeostasis, and in coordinating immune responses.

    • Akshay T. Krishnamurty
    •  & Shannon J. Turley
    Nature Immunology 21, 369-380
  • Research
    | Open Access

    Immune cells mostly enter lymph nodes (LN) from blood circulation, but whether afferent lymphatics contributes to LN entry is unclear. Here, the authors show, using a photo-convertible reporter, that T cells in afferent lymphatics frequently enter LN and become arrested in the subcapsular sinus, with chemokines and integrins further guiding their migration in the LN.

    • Rieke Martens
    • , Marc Permanyer
    • , Kathrin Werth
    • , Kai Yu
    • , Asolina Braun
    • , Olga Halle
    • , Stephan Halle
    • , Gwendolyn E. Patzer
    • , Berislav Bošnjak
    • , Friedemann Kiefer
    • , Anika Janssen
    • , Michaela Friedrichsen
    • , Jenny Poetzsch
    • , Karan Kohli
    • , Yvonne Lueder
    • , Rodrigo Gutierrez Jauregui
    • , Nadine Eckert
    • , Tim Worbs
    • , Melanie Galla
    •  & Reinhold Förster
  • Research
    | Open Access

    Lymphatic endothelial cells (LECs) can cross-present antigen to naïve CD8+ T cells, but the significance of this interaction was unclear. Here the authors show that LECs directly induce CD8+ T cell differentiation with memory-like phenotypes, migration patterns and transcriptome, which can later be recalled to promote effector immunity and protection from Listeria infection.

    • Efthymia Vokali
    • , Shann S. Yu
    • , Sachiko Hirosue
    • , Marcela Rinçon-Restrepo
    • , Fernanda V. Duraes
    • , Stefanie Scherer
    • , Patricia Corthésy-Henrioud
    • , Witold W. Kilarski
    • , Anna Mondino
    • , Dietmar Zehn
    • , Stéphanie Hugues
    •  & Melody A. Swartz

News and Comment

  • News & Views |

    B cells undergo iterative rounds of somatic hypermutation and selection for high-affinity antigen binding in the germinal center microenvironment. Two new studies provide insights into the temporal and spatial control mechanisms that act within B cells and follicular dendritic cells to jointly govern B cell differentiation and cell traffic within the GC.

    • Jagan R. Muppidi
    •  & Ulf Klein
    Nature Immunology 21, 599-601
  • News & Views |

    The biodistribution of the components of a messenger RNA vaccine following its administration in non-human primates can be non-invasively monitored by labelling the vaccine with a dual radionuclide–near-infrared probe.

    • Sebastian Ols
    •  & Karin Loré
  • News & Views |

    The cytokine IL-17 augments metabolism in fibroblastic reticular cells in lymph nodes, which enhances their proliferation and survival to support B cell responses during autoimmunity.

    • Scott N. Mueller
    Nature Immunology 20, 524-526
  • Research Highlights |

    Lee et al. show that in a mouse model of melanoma, tumour cells that spread to the draining lymph node adapt to the fatty acid-rich environment in the lymph node by activation of YAP signalling and fatty acid oxidation.

    • Ulrike Harjes