Lyme disease

Lyme disease, formerly known as Lyme arthritis, is an infectious disease transmitted to humans by deer ticks infected with the spirochete Borrelia burgdorferi. The primary infection can spread to secondary sites including the nervous system, heart and musculoskeletal system.

Latest Research and Reviews

Reviews | 05 July 2021

Lyme arthritis: linking infection, inflammation and autoimmunity

Lyme arthritis, a manifestation of Lyme disease, can sometimes persist in a chronic post-infectious disease. In this Review, the authors argue that post-infectious Lyme arthritis could act as a model to improve understanding of other forms of chronic arthritis.
- Robert B. Lochhead
- , Klemen Strle
- & Allen C. Steere
Nature Reviews Rheumatology 17, 449-461
Reviews | 10 July 2020

Interactions between Borrelia burgdorferi and ticks

Borrelia burgdorferi has a complex life cycle with several different hosts, causing Lyme disease when it infects humans. In this Review, Fikrig and colleagues discuss how B. burgdorferi infects and interacts with its tick vector to ensure onward transmission.
- Cheyne Kurokawa
- , Geoffrey E. Lynn
- & Erol Fikrig
Nature Reviews Microbiology 18, 587-600
Reviews | 15 December 2016

Lyme borreliosis

Lyme borreliosis is a tick-borne disease, caused by three genospecies of Borrelia burgdorferi sensu lato, that can cause a distinctive skin lesion, and neurological and cardiovascular symptoms. This PrimeView focuses on the epidemiology of Lyme borreliosis.

Nature Reviews Disease Primers 2, 16091
Reviews | 15 December 2016

Lyme borreliosis

Lyme borreliosis is a tick-borne disease that is caused by the bacteria Borrelia burgdorferi, Borrelia afzelii and Borrelia garinii. This Primer by Steere and colleagues discusses the epidemiology, mechanisms and management of Lyme borreliosis in North America and Europe.
- Allen C. Steere
- , Franc Strle
- & Paul S. Mead
Nature Reviews Disease Primers 2, 16090
Research
01 August 2016 | Open Access

Species interactions in occurrence data for a community of tick-transmitted pathogens
- Agustín Estrada-Peña
- & José de la Fuente
Scientific Data 3, 160056
Research
09 February 2016 | Open Access

Genomic insights into the Ixodes scapularis tick vector of Lyme disease

Ticks transmit a large number of pathogens that cause human diseases. Here, the authors sequence the genome of the tick Ixodes scapularisand uncover expansion of genes associated with parasitic processes unique to ticks and tick-host interactions.
- Monika Gulia-Nuss
- , Andrew B. Nuss
- & Catherine A. Hill
Nature Communications 7, 10507

All Research & Reviews

News and Comment

Research Highlights | 01 February 2018

Bystander-activated T cells contribute to Lyme arthritis
- Sarah Onuora
Nature Reviews Rheumatology 14, 123
Research Highlights | 30 September 2014

Immune surveillance stops joint-invading Borrelia in mice
- Sarah Onuora
Nature Reviews Rheumatology 10, 638
Research Highlights | 19 September 2014

Lyme scaled back

Invariant natural killer T cells can directly limit bacterial dissemination into the joints.
- Yvonne Bordon
Nature Reviews Immunology 14, 649
News | 07 July 2014

Resurrecting the 'yuppie vaccine'

The only vaccine ever approved to protect against Lyme disease was pulled off the market in 2002, and drugmakers have yet to offer an alternative. What's taking so long? Cassandra Willyard investigates.
- Cassandra Willyard
Nature Medicine 20, 698-701
News & Views | 09 April 2013

Monoarthritis risk stratification in Lyme disease

In Lyme disease endemic areas, a noninvasive clinical prediction model to distinguish septic arthritis from Lyme arthritis would be useful, especially in children. A new study suggests that in highly selected patients, such prediction might be possible. But failure to recognize even a few cases of septic arthritis could have devastating consequences.
- Robert T. Schoen
Nature Reviews Rheumatology 9, 261-262
Research Highlights | 17 July 2012

Spirochaete remnants could explain antibiotic-refractory Lyme arthritis
- Sarah Onuora
Nature Reviews Rheumatology 8, 440

All News & Comment

Lyme disease

Latest Research and Reviews

Lyme arthritis: linking infection, inflammation and autoimmunity

Interactions between Borrelia burgdorferi and ticks

Lyme borreliosis

Lyme borreliosis

Species interactions in occurrence data for a community of tick-transmitted pathogens

Genomic insights into the Ixodes scapularis tick vector of Lyme disease

News and Comment

Bystander-activated T cells contribute to Lyme arthritis

Immune surveillance stops joint-invading Borrelia in mice

Lyme scaled back

Resurrecting the 'yuppie vaccine'

Monoarthritis risk stratification in Lyme disease

Spirochaete remnants could explain antibiotic-refractory Lyme arthritis

Search

Quick links