Lyme disease articles from across Nature Portfolio

Lyme arthritis, a manifestation of Lyme disease, can sometimes persist in a chronic post-infectious disease. In this Review, the authors argue that post-infectious Lyme arthritis could act as a model to improve understanding of other forms of chronic arthritis.

Borrelia burgdorferi has a complex life cycle with several different hosts, causing Lyme disease when it infects humans. In this Review, Fikrig and colleagues discuss how B. burgdorferi infects and interacts with its tick vector to ensure onward transmission.

Lyme borreliosis is a tick-borne disease, caused by three genospecies of Borrelia burgdorferi sensu lato, that can cause a distinctive skin lesion, and neurological and cardiovascular symptoms. This PrimeView focuses on the epidemiology of Lyme borreliosis.

Lyme borreliosis is a tick-borne disease that is caused by the bacteria Borrelia burgdorferi, Borrelia afzelii and Borrelia garinii. This Primer by Steere and colleagues discusses the epidemiology, mechanisms and management of Lyme borreliosis in North America and Europe.

Ticks transmit a large number of pathogens that cause human diseases. Here, the authors sequence the genome of the tick Ixodes scapularisand uncover expansion of genes associated with parasitic processes unique to ticks and tick-host interactions.

Invariant natural killer T cells can directly limit bacterial dissemination into the joints.

The only vaccine ever approved to protect against Lyme disease was pulled off the market in 2002, and drugmakers have yet to offer an alternative. What's taking so long? Cassandra Willyard investigates.

In Lyme disease endemic areas, a noninvasive clinical prediction model to distinguish septic arthritis from Lyme arthritis would be useful, especially in children. A new study suggests that in highly selected patients, such prediction might be possible. But failure to recognize even a few cases of septic arthritis could have devastating consequences.