Long-term potentiation articles from across Nature Portfolio

The role of serotonin in prefrontal cortex development remains unexplored. Here, authors show that serotonin regulates maturation and stabilization of prefrontal excitatory synapses.

Brain mitochondria serve as local energy supplies for synapses, and the mechanisms that stabilize mitochondria near dendritic spines are not fully understood. Here, the authors identify the vesicle-associated membrane protein-associated protein VAP as a mitochondrial stabilizer in spatially supporting synaptic plasticity.

Memory consolidation requires hippocampal ripples. Here the authors show that AMPA receptor mobilisation at CA3 recurrent synapses is required for ripple-dependent rule consolidation.

Mice with myeloid-specific loss of the transcription factor, Stat4, exhibit stronger long-term synaptic plasticity than control animals when given a high-fat, high-cholesterol diet, suggesting that suppressing Stat4 activation may be a useful strategy for protecting against the inflammatory effects of a Western diet.

Several independent lines of evidence demonstrated long-term potentiation induction by a structural function of calmodulin-dependent protein kinase II rather than by its enzymatic activity.

A study reports that in the mouse hippocampus, the induction of long-term potentiation is dependent on the structural functions of CaMKII and not its enzymatic activity.

Adult male rodents have long been known to show stronger hippocampal long-term potentiation (LTP) and learning than females. Le et al. find that this sex difference is reversed in pre-pubescent animals, and identify a female-specific mechanism that increases LTP threshold and decreases spatial memory in females after puberty.

Selective and transient erasure of LTP reveals the roles of synaptic plasticity at multiple stages of memory consolidation.

In mice, long-term potentiation of hippocampal–nucleus accumbens synapses is required for the formation of reward-related memories.

Dendritic mitochondria in stimulated neurons undergo fission that is required for long-term potentiation.