Long-term potentiation

Long-term potentiation (LTP ) is the biological process by which certain types of synaptic stimulation – such as prolonged high frequency input – result in a long-lasting increase in the strength of synaptic transmission. It is thought that the mechanisms underlying LTP, together with those underlying long-term depression, may contribute to synaptic plasticity during learning.

Latest Research and Reviews

News and Comment

  • News & Views |

    Adult male rodents have long been known to show stronger hippocampal long-term potentiation (LTP) and learning than females. Le et al. find that this sex difference is reversed in pre-pubescent animals, and identify a female-specific mechanism that increases LTP threshold and decreases spatial memory in females after puberty.

    • Natalie C. Tronson
    Nature Neuroscience 25, 134-135
  • News & Views |

    Protein kinases are key regulators of excitatory synapse plasticity. In this issue, using novel optical reporters of protein kinase C (PKC) activity, Colgan et al. identify PKCα as critical for integrating NMDA receptor and neurotrophin signaling to control dendritic spine structural plasticity, synaptic potentiation, and learning and memory.

    • Mark L. Dell’Acqua
    •  & Kevin M. Woolfrey
    Nature Neuroscience 21, 1021-1022