Long-term depression articles from across Nature Portfolio

Endocannabinoids are important modulators of synaptic transmission, although their mechanism of release is unknown. In this study, the authors found that endocannabinoid postsynaptic release is mediated by synucleins via a synuclein-dependent and SNARE-dependent mechanism.

Cortical inhibitory interneurons undergo diverse forms of long-term synaptic plasticity. In this Review, Sjöström and colleagues describe the diversity of this interneuron plasticity and highlight that the plasticitome, a comprehensive database of plasticity rules, is needed to understand circuit plasticity complexity.

Electrophysiological recordings from Purkinje cells in mice show that the potential for induction of long-term depression may vary with molecular identity

Using new phagocytosis reporter mice and 3D ultrastructural characterization, Morizawa et al. show that motor learning induces synaptic engulfment by BG, which contributes to synaptic pruning during the improvement of motor adaptation.

The synaptic protein SynGAP exerts its effects on synaptic plasticity via a structural role rather than its GTPase-activating protein activity.

Activation of microglial complement receptor 3 by an inflammatory stimulus in the presence of hypoxia induces long-term depression of synaptic transmission in the hippocampus.