Long-term depression articles from across Nature Portfolio

Cortical inhibitory interneurons undergo diverse forms of long-term synaptic plasticity. In this Review, Sjöström and colleagues describe the diversity of this interneuron plasticity and highlight that the plasticitome, a comprehensive database of plasticity rules, is needed to understand circuit plasticity complexity.

Electrophysiological recordings from Purkinje cells in mice show that the potential for induction of long-term depression may vary with molecular identity

Using new phagocytosis reporter mice and 3D ultrastructural characterization, Morizawa et al. show that motor learning induces synaptic engulfment by BG, which contributes to synaptic pruning during the improvement of motor adaptation.

Previous work has identified synaptic eligibility traces in slice preparations. Here the authors provide demonstration of eligibility traces in vivo during reinforcement learning.

It remains unclear how corticostriatal synapses utilize reward prediction error signaling in order to reinforce reward-related behaviors. Here, the authors show that potentiation of corticostriatal synapses requires phasic dopamine activation, pauses in striatal cholinergic interneuron firing, and depolarization of spiny projection neurons.