Kidney diseases articles from across Nature Portfolio

Defective nicotinamide adenine dinucleotide (NAD⁺) metabolism is involved in various diseases. A study in Nature Metabolism identifies the cytosolic mitochondrial-RNA sensing system as a mediator that links NAD⁺ deficiency to kidney disease in humans and mice.

Two studies have applied a mechanical stimulus directly to a cilium, independent of a chemical signal, and demonstrated that force-based bending of a single nodal axoneme is sufficient to induce intraciliary Ca²⁺ flux in a PKD2-dependent manner, which propagates to drive asymmetric gene expression.

Analyses of data from the Danish national patient register show that diabetes mellitus increases the risk of end-stage renal disease in patients with systemic lupus erythematosus.