Ion channel signalling articles from across Nature Portfolio

Ion channel signalling involves the activation of an ion channel to permit the flow of ions through it. It regulates neurotransmission, secretion and muscle contraction. Ion channel signalling can originate at the plasma membrane or at endomembranes in response to changes in membrane potential, chemical compounds, light or mechanical stress.

Latest Research and Reviews

Research
06 March 2023 | Open Access

The TRPM7 channel reprograms cellular glycolysis to drive tumorigenesis and angiogenesis
- Wanzhou Wu
- , Xuan Wang
- & Yongping Bai
Cell Death & Disease 14, 183
Research | 06 March 2023

Thermogenic adipocyte-derived zinc promotes sympathetic innervation in male mice

Sympathetic innervation of brown and white adipose tissue is shown to be promoted by zinc released from thermogenic adipocytes, revealing a positive feedback mechanism for regulation of thermogenesis and thereby energy expenditure.
- Junkun Jiang
- , Donglei Zhou
- & Bing Luan
Nature Metabolism 5, 481-494
Research
07 December 2022 | Open Access

The mitochondrial Ca²⁺ uniporter channel synergizes with fluid shear stress to induce mitochondrial Ca²⁺ oscillations
- Akshar Patel
- , Matthew Simkulet
- & B. Rita Alevriadou
Scientific Reports 12, 21161
Research
03 December 2022 | Open Access

Membrane curvature governs the distribution of Piezo1 in live cells

This study demonstrates that the curvature of the cell membrane directly regulates the spatial distribution of Piezo1, a widely expressed mechanosensitive ion channel. Piezo1 may flatten upon activation and can mechanically inhibit membrane dynamics
- Shilong Yang
- , Xinwen Miao
- & Zheng Shi
Nature Communications 13, 7467
Research
05 November 2022 | Open Access

Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR

The plasma membrane’s electrical potential is maintained by ion channels, though the impact of this potential on cell fate has not been clearly elucidated. Here they show that changes in membrane potential can affect calcium levels and mTOR in pluripotent stem cells, altering their transition from pluripotency to differentiation.
- Emily Sempou
- , Valentyna Kostiuk
- & Mustafa K. Khokha
Nature Communications 13, 6681
Research
03 November 2022 | Open Access

Butyrate reduces cellular magnesium absorption independently of metabolic regulation in Caco-2 human colon cells
- Lisanne M. M. Gommers
- , Pieter A. Leermakers
- & Joost G. J. Hoenderop
Scientific Reports 12, 18551

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News and Comment

Research Highlights | 22 December 2022

Crank up the volume: Osmotic stress induces WNK1 phase separation
- Ji-Ung Jung
- , Clinton A. Taylor IV
- & Melanie H. Cobb
Cell Research, 1-2
Research Highlights | 22 April 2022

Cuproptosis: a new form of programmed cell death
- Yongqiang Wang
- , Long Zhang
- & Fangfang Zhou
Cellular & Molecular Immunology 19, 867-868
News & Views | 28 March 2022

Activation of macrophage TRPM2 and CD36 promotes atherosclerosis

Global or macrophage-specific knockout of Trpm2, which encodes the calcium-permeable ion channel TRPM2, protects mice against atherosclerosis induced by a high-fat diet. Mechanistically, activation of TRPM2 and the scavenger receptor CD36 promote the transformation of macrophages into inflammatory foam cells, thereby accelerating the development and progression of atherosclerosis.

Nature Cardiovascular Research 1, 294-295
Correspondence | 07 January 2022

Structural basis for the gating modulation of Kv4.3 by auxiliary subunits
- Demin Ma
- , Cheng Zhao
- & Dongwu Lai
Cell Research 32, 411-414
Research Highlights | 08 October 2021

Noble sensations

The 2021 Nobel Prize in Physiology or Medicine goes to David Julius and Ardem Patapoutian for their work on molecular basis of somatosensation.
- Paulina Strzyz
Nature Reviews Molecular Cell Biology 22, 775
Correspondence
31 August 2021 | Open Access

Cryo-EM structures of human TMEM120A and TMEM120B
- Meng Ke
- , Yue Yu
- & Zhen Yan
Cell Discovery 7, 77

All News & Comment

Ion channel signalling articles from across Nature Portfolio

Latest Research and Reviews

The TRPM7 channel reprograms cellular glycolysis to drive tumorigenesis and angiogenesis

Thermogenic adipocyte-derived zinc promotes sympathetic innervation in male mice

The mitochondrial Ca²⁺ uniporter channel synergizes with fluid shear stress to induce mitochondrial Ca²⁺ oscillations

Membrane curvature governs the distribution of Piezo1 in live cells

Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR

Butyrate reduces cellular magnesium absorption independently of metabolic regulation in Caco-2 human colon cells

News and Comment

Crank up the volume: Osmotic stress induces WNK1 phase separation

Cuproptosis: a new form of programmed cell death

Activation of macrophage TRPM2 and CD36 promotes atherosclerosis

Structural basis for the gating modulation of Kv4.3 by auxiliary subunits

Noble sensations

Cryo-EM structures of human TMEM120A and TMEM120B

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