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Modulating hierarchical self-assembly in thermoresponsive intrinsically disordered proteins through high-temperature incubation time
- Vaishali Sethi
- , Dana Cohen-Gerassi
- & Roy Beck
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| Open Access
Intramolecular interaction kinetically regulates fibril formation by human and mouse α-synuclein
- Takashi Ohgita
- , Hiroki Kono
- & Hiroyuki Saito
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Rational peptide design for inhibition of the KIX–MLL interaction
- Nao Sato
- , Shunji Suetaka
- & Munehito Arai
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Rational design of phase separating peptides based on phase separating protein sequence of p53
- Kiyoto Kamagata
- , Atsumi Hando
- & Keisuke Ikeda
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Aggregation of alpha-synuclein in enteric neurons does not impact function in vitro
- Adam J. Bindas
- , Kyla N. Nichols
- & Ryan A. Koppes
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The interaction between LC8 and LCA5 reveals a novel oligomerization function of LC8 in the ciliary-centrosome system
- Tamás Szaniszló
- , Máté Fülöp
- & Zsuzsanna Dosztányi
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Rational peptide design for regulating liquid–liquid phase separation on the basis of residue–residue contact energy
- Kiyoto Kamagata
- , Maulana Ariefai
- & Tomoshi Kameda
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Structure-dependent recruitment and diffusion of guest proteins in liquid droplets of FUS
- Kiyoto Kamagata
- , Nanako Iwaki
- & Seiji Sakomoto
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Kinetic interplay between droplet maturation and coalescence modulates shape of aged protein condensates
- Adiran Garaizar
- , Jorge R. Espinosa
- & Rosana Collepardo-Guevara
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Rational design of a helical peptide inhibitor targeting c-Myb–KIX interaction
- Shunji Suetaka
- , Yoshiki Oka
- & Munehito Arai
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Peptide backbone modifications of amyloid β (1–40) impact fibrillation behavior and neuronal toxicity
- Benedikt Schwarze
- , Alexander Korn
- & Daniel Huster
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Zn(II) binding causes interdomain changes in the structure and flexibility of the human prion protein
- Maciej Gielnik
- , Michał Taube
- & Maciej Kozak
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Molecular principles of recruitment and dynamics of guest proteins in liquid droplets
- Kiyoto Kamagata
- , Nanako Iwaki
- & Yaakov Levy
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PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions
- Sonia T. Nicolaou
- , Max Hebditch
- & Jim Warwicker
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Homopeptide and homocodon levels across fungi are coupled to GC/AT-bias and intrinsic disorder, with unique behaviours for some amino acids
- Yue Wang
- & Paul M. Harrison
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Non-coding RNA suppresses FUS aggregation caused by mechanistic shear stress on pipetting in a sequence-dependent manner
- Nesreen Hamad
- , Ryoma Yoneda
- & Masato Katahira
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Characterization of design grammar of peptides for regulating liquid droplets and aggregates of FUS
- Kiyoto Kamagata
- , Rika Chiba
- & Tomoshi Kameda
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The N-terminal region of Jaw1 has a role to inhibit the formation of organized smooth endoplasmic reticulum as an intrinsically disordered region
- Takuma Kozono
- , Hiroyuki Sato
- & Atsushi Nishikawa
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Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils
- Adriana Savastano
- , Garima Jaipuria
- & Markus Zweckstetter
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A combined NMR and EPR investigation on the effect of the disordered RGG regions in the structure and the activity of the RRM domain of FUS
- A. Bonucci
- , M. G. Murrali
- & R. Pierattelli
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Article
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CMT-3 targets different α-synuclein aggregates mitigating their toxic and inflammogenic effects
- Florencia González-Lizárraga
- , Diego Ploper
- & Rosana Chehín
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Membrane stiffness and myelin basic protein binding strength as molecular origin of multiple sclerosis
- Benjamin Krugmann
- , Aurel Radulescu
- & Andreas M. Stadler
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Lipid membrane templated misfolding and self-assembly of intrinsically disordered tau protein
- Jaroslaw Majewski
- , Emmalee M. Jones
- & Eva Y. Chi
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Characterization of partially ordered states in the intrinsically disordered N-terminal domain of p53 using millisecond molecular dynamics simulations
- Pablo Herrera-Nieto
- , Adrià Pérez
- & Gianni De Fabritiis
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Presence of intrinsically disordered proteins can inhibit the nucleation phase of amyloid fibril formation of Aβ(1–42) in amino acid sequence independent manner
- Koki Ikeda
- , Shota Suzuki
- & Hidekazu Hiroaki
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The hot sites of α-synuclein in amyloid fibril formation
- Anahita Khammari
- , Seyed Shahriar Arab
- & Mohammad Reza Ejtehadi
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Molecular and cellular correlates in Kv channel clustering: entropy-based regulation of cluster ion channel density
- Limor Lewin
- , Esraa Nsasra
- & Ofer Yifrach
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Cyclophilin D binds to the acidic C-terminus region of α-Synuclein and affects its aggregation characteristics
- James Torpey
- , Jillian Madine
- & Lu-Yun Lian
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Cellular polyamines condense hyperphosphorylated Tau, triggering Alzheimer’s disease
- Stefan M. Ivanov
- , Mariyana Atanasova
- & Irini A. Doytchinova
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| Open Access
Taurine Induces an Ordered but Functionally Inactive Conformation in Intrinsically Disordered Casein Proteins
- Mohd Younus Bhat
- , Laishram Rajendrakumar Singh
- & Tanveer Ali Dar
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The small molecule inhibitor anle145c thermodynamically traps human islet amyloid peptide in the form of non-cytotoxic oligomers
- Manikam S. Saravanan
- , Sergey Ryazanov
- & J. Antoinette Killian
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| Open Access
Increased Dynamics of α-Synuclein Fibrils by β-Synuclein Leads to Reduced Seeding and Cytotoxicity
- Xue Yang
- , Jonathan K. Williams
- & Jean Baum
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Characterization of the dynamics and the conformational entropy in the binding between TAZ1 and CTAD-HIF-1α
- Ida Nyqvist
- & Jakob Dogan
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Amino acid substitution scoring matrices specific to intrinsically disordered regions in proteins
- Rakesh Trivedi
- & Hampapathalu Adimurthy Nagarajaram
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Amyloid fibrils prepared using an acetylated and methyl amidated peptide model of the α-Synuclein NAC 71–82 amino acid stretch contain an additional cross-β structure also found in prion proteins
- Thomas Näsström
- , Per Ola Andersson
- & Björn C. G. Karlsson
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| Open Access
Structural Dynamics of the N-Extension of Cardiac Troponin I Complexed with Troponin C by Site-Directed Spin Labeling Electron Paramagnetic Resonance
- Chenchao Zhao
- , Takayasu Somiya
- & Toshiaki Arata
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Concatenation of 14-3-3 with partner phosphoproteins as a tool to study their interaction
- Kristina V. Tugaeva
- , Daria I. Kalacheva
- & Nikolai N. Sluchanko
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Role of protein conformation and weak interactions on γ-gliadin liquid-liquid phase separation
- Line Sahli
- , Denis Renard
- & Adeline Boire
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| Open Access
Transient multimers modulate conformer abundances of prion protein monomer through conformational selection
- Guillaume Van der Rest
- , Human Rezaei
- & Frédéric Halgand
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Differential binding affinity of tau repeat region R2 with neuronal-specific β-tubulin isotypes
- Vishwambhar Vishnu Bhandare
- , Bajarang Vasant Kumbhar
- & Ambarish Kunwar
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Article
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Rational design using sequence information only produces a peptide that binds to the intrinsically disordered region of p53
- Kiyoto Kamagata
- , Eriko Mano
- & Tomoshi Kameda
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Characterization of protein extracts from different types of human teeth and insight in biomineralization
- Vaibhav Sharma
- , Alagiri Srinivasan
- & Saroj Kumar
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Calcium binding to a disordered domain of a type III-secreted protein from a coral pathogen promotes secondary structure formation and catalytic activity
- Elisabeth Hoyer
- , Julius Knöppel
- & Jana Oertel
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Designed Mutations Alter the Binding Pathways of an Intrinsically Disordered Protein
- Di Wu
- & Huan-Xiang Zhou
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Calcitonin native prefibrillar oligomers but not monomers induce membrane damage that triggers NMDA-mediated Ca2+-influx, LTP impairment and neurotoxicity
- Marcello Belfiore
- , Ida Cariati
- & Marco Diociaiuti
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Probing Membrane Association of α-Synuclein Domains with VDAC Nanopore Reveals Unexpected Binding Pattern
- Daniel Jacobs
- , David P. Hoogerheide
- & Sergey M. Bezrukov
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Article
| Open Access
A dynamically interacting flexible loop assists oligomerisation of the Caenorhabditis elegans centriolar protein SAS-6
- Julia M. C. Busch
- , Michèle C. Erat
- & Ioannis Vakonakis
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| Open Access
Novel model of secreted human tau protein reveals the impact of the abnormal N-glycosylation of tau on its aggregation propensity
- Yelena Losev
- , Ashim Paul
- & Daniel Segal
An aberrant fused in sarcoma liquid droplet of amyotrophic lateral sclerosis pathological variant, R495X, accelerates liquid–solid phase transition
Metal ions shape α-synuclein