Interventional cardiology articles from across Nature Portfolio

Statins exert cardiovascular protective effects that are independent of cholesterol lowering. Using endothelial cells derived from induced pluripotent stem cells, Liu et al. show that statins can improve endothelial dysfunction by inhibiting endothelial–mesenchymal transition via epigenetic regulation of the GGTase–RhoA–YAP1–SOX9 signaling pathway.

Factor XIa inhibitors are being tested in clinical trials, with the assumption that these agents are as effective as direct oral anticoagulants but cause fewer bleeding events. Findings from phase II trials of direct inhibitors of factor XIa for the prevention of first-ever and recurrent ischaemic stroke or recurrent major coronary artery events suggest fewer bleeding events but with uncertainty about efficacy.

Tricuspid transcatheter edge-to-edge repair in patients with severe tricuspid regurgitation improved quality of life and reduced disease severity compared with medical therapy

In patients with complex coronary lesions, percutaneous coronary intervention guided by intravascular imaging improved cardiovascular outcomes compared with percutaneous coronary intervention guided by angiography.

Immediate complete revascularization is as safe and effective as staged complete revascularization in patients with acute coronary syndrome and multivessel disease, according to findings from the BIOVASC trial.

In the Evolut Low Risk study, transcatheter aortic valve implantation in low-risk patients with severe aortic stenosis compared favourably with surgical aortic valve replacement in terms of all-cause mortality or disabling stroke at 3 years.