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Article
| Open Access
Deep convolutional neural networks to predict cardiovascular risk from computed tomography
Coronary artery calcium is an accurate predictor of cardiovascular events but this information is not routinely quantified. Here the authors show a robust and time-efficient deep learning system to automatically quantify coronary calcium on CT scans and predict cardiovascular events in a large, multicentre study.
- Roman Zeleznik
- , Borek Foldyna
- & Hugo J. W. L. Aerts
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Article
| Open Access
Perioperative use of renin-angiotensin system inhibitors and outcomes in patients undergoing cardiac surgery
Renin-angiotensin system inhibitors (RASi) are beneficial in several classes of cardiovascular patients. However, whether their perioperative use is beneficial and/or safe in cardiac surgery is unclear. Here the authors perform a multicenter retrospective cohort study showing that preoperative and postoperative use of RASi is associated with reduction of mortality in patients undergoing cardiac surgery.
- Qian Ding
- , Zugui Zhang
- & Jianzhong Sun
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Article
| Open Access
Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias
Catheter ablation is a common therapy for atrial fibrillation but disrupts cardiac cholinergic neurons. Here the authors report that cholinergic neurons innervate heart ventricles and show that their ablation leads to increased susceptibility to ventricular arrhythmias in mouse models and in patients.
- Christiane Jungen
- , Katharina Scherschel
- & Christian Meyer
A tough nitric oxide-eluting hydrogel coating suppresses neointimal hyperplasia on vascular stent