Interleukins articles from across Nature Portfolio

Interleukins are cytokines produced and secreted mainly by CD3+ and CD4+ T lymphocytes. Interleukins promote development and differentiation of natural killer cells, T and B lymphocytes and haematopoietic stem cells. Interleukins are involved in systemic inflammation and immune system modulation, so play important roles in fighting cancer, infectious disease and other diseases.

Latest Research and Reviews

Research
06 June 2023 | Open Access

Growth hormone releasing hormone signaling promotes Th17 cell differentiation and autoimmune inflammation

Endocrine factors have been shown to alter functions of pathogenic Th17 cells that are involved in autoimmunity. Here the authors study the influence of growth hormone releasing hormone receptor and show that this receptor is found on Th17 cells and promotes ocular autoimmunity.
- Lin Du
- , Bo Man Ho
- & Wai Kit Chu
Nature Communications 14, 3298
Research
25 May 2023 | Open Access

Reciprocal costimulatory molecules control the activation of mucosal type 3 innate lymphoid cells during engagement with B cells
- Xinping Lv
- , Shan Zhu
- & Jingtao Chen
Cellular & Molecular Immunology, 1-12
Research | 23 May 2023

Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation
- Songling Zhu
- , Shufen Zhong
- & Yaguang Zhang
Cellular & Molecular Immunology, 1-14
Research
06 May 2023 | Open Access

Sox13 and M2-like leukemia-associated macrophages contribute to endogenous IL-34 caused accelerated progression of acute myeloid leukemia
- Dongyue Zhang
- , Xiaoxi Cui
- & Guoguang Zheng
Cell Death & Disease 14, 308
Research
29 April 2023 | Open Access

Effect of remote ischemic conditioning on the immune-inflammatory profile in patients with traumatic hemorrhagic shock in a randomized controlled trial
- C. H. Leung
- , S. B. Rizoli
- & O. D. Rotstein
Scientific Reports 13, 7025
Research
29 April 2023 | Open Access

PPAR-γ regulates the effector function of human T helper 9 cells by promoting glycolysis

IL-9-producing helper T (T_H9) cells contribute to allergic inflammation. In this study, the authors demonstrate that the transcription factor PPAR-γ regulates T_H9 effector function by promoting glucose metabolism and mTOR signaling in human allergic contact dermatitis.
- Nicole L. Bertschi
- , Oliver Steck
- & Christoph Schlapbach
Nature Communications 14, 2471

All Research & Reviews

News and Comment

Research Highlights | 22 May 2023

Tissue repairing cytokine
- Ioana Visan
Nature Immunology 24, 886
Research Highlights | 15 November 2022

Gasdermin D as a cellular switch to orientate immune responses via IL-33 or IL-1β
- Camille Chauvin
- , Sruthi Vijaya Retnakumar
- & Jagadeesh Bayry
Cellular & Molecular Immunology 20, 8-10
News & Views | 06 July 2022

Gasdermin D pores for IL-33 release

In airway epithelial cells, exposure to allergen proteases induces the stress granules-mediated transfer of IL-33 from the nucleus to the cytoplasm and extracellular release through gasdermin D pores containing a newly described active fragment.
- Hirohito Kita
Nature Immunology 23, 989-991
Research Highlights | 28 June 2022

Inflammatory macrophages
- Ioana Visan
Nature Immunology 23, 988
Correspondence | 08 June 2022

Dysregulation of IL-34 ligation to SDC-1 mitigates collagen-induced arthritis
- Anja Meyer
- , Ryan Sienes
- & Shiva Shahrara
Cellular & Molecular Immunology 19, 1070-1072
News & Views | 26 May 2022

Gene delivery of interleukin 2 treats neuro-inflammation in traumatic brain injury

Using a gene-delivery system, we show that ectopic expression of interleukin 2 (IL-2) within reactive astrocytes stimulates brain-specific expansion of resident regulatory T cells. Such gene delivery protects against neuroinflammation in several mouse models of disease and injury, with potential implications for patients with traumatic brain injuries.

Nature Immunology 23, 834-835

All News & Comment

Interleukins articles from across Nature Portfolio

Latest Research and Reviews

Growth hormone releasing hormone signaling promotes Th17 cell differentiation and autoimmune inflammation

Reciprocal costimulatory molecules control the activation of mucosal type 3 innate lymphoid cells during engagement with B cells

Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation

Sox13 and M2-like leukemia-associated macrophages contribute to endogenous IL-34 caused accelerated progression of acute myeloid leukemia

Effect of remote ischemic conditioning on the immune-inflammatory profile in patients with traumatic hemorrhagic shock in a randomized controlled trial

PPAR-γ regulates the effector function of human T helper 9 cells by promoting glycolysis

News and Comment

Tissue repairing cytokine

Gasdermin D as a cellular switch to orientate immune responses via IL-33 or IL-1β

Gasdermin D pores for IL-33 release

Inflammatory macrophages

Dysregulation of IL-34 ligation to SDC-1 mitigates collagen-induced arthritis

Gene delivery of interleukin 2 treats neuro-inflammation in traumatic brain injury

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