Interferons articles from across Nature Portfolio

The RNA exonuclease REXO2 plays an important role in the degradation of mitochondrial RNA. Authors here describe a dominant negative REXO2 mutation that causes autoinflammatory disease via Type I IFN activation.

Multiple sclerosis and some other neuroinflammatory diseases are associated with aberrant CD4⁺ T cell differentiation and regulatory T cell function. Here authors show that the E3 ubiquitin ligase RNF213 is central to both physiological and pathologic CD4⁺ T cell differentiation, and finetunes IFN-β responses in multiple sclerosis.

In this Review, the authors summarize the literature around immune cancer cell STING signaling and how it is finely balanced between pro-tumorigenic and anti-tumorigenic functions.

Here, Jacobsen et al show that Varicella zoster virus glycoprotein C binds interferon gamma and induces biased signalling through its receptor, leading to higher expression of adhesion molecules, more T cell adhesion and viral spread from epithelial cells.

Extrafollicular and germinal center reactions are considered to represent sequential phases of a primary B cell response. A study now demonstrates the ability of autocrine IL-12 to promote extrafollicular differentiation into plasmablasts, while inhibiting germinal center responses.

Determining the immune crosstalk between macrophages and NK cells in bronchioalveolar lavage fluid during SARS-CoV-2 infection in macaques identifies immunoregulatory properties of NK cells and their implications for viral persistence.