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Article
| Open Access
Early-adulthood spike in protein translation drives aging via juvenile hormone/germline signaling
The transient elevation in protein translation during early-adulthood in Drosophila imposes long-lasting negative impacts on future aging trajectories by triggering proteostatic dysfunction at old ages.
- Harper S. Kim
- , Danitra J. Parker
- & Andrew M. Pickering
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Article
| Open Access
MAPK-dependent hormonal signaling plasticity contributes to overcoming Bacillus thuringiensis toxin action in an insect host
Bacillus thuringiensis (Bt) is an important bioinsecticide, but high-level resistance has been rapidly evolving in agricultural pests. Here, Guo et al. show that the MAPK cascade can be activated by enhanced upstream insect hormone signals to counter Bt virulence in the diamondback moth.
- Zhaojiang Guo
- , Shi Kang
- & Youjun Zhang
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Article
| Open Access
Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones
Insulin-like polypeptide binding proteins (IBPs) from insects can bind diverse insulin-like proteins (ILPs) including human insulin and IGFs. Here, the authors present structures of a Drosophila IBP in its free and ILP-bound forms, providing insights into the regulation of ILP bioavailability by insect IBPs.
- Nikolaj Kulahin Roed
- , Cristina M. Viola
- & Andrzej M. Brzozowski
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A mutation in the receptor Methoprene-tolerant alters juvenile hormone response in insects and crustaceans
Juvenile hormone (JH) is a key regulator of development both in insects and the crustacea Daphnia pulex and D. magna. Here, Miyakawa et al.investigate the evolutionary significance of a single amino-acid variation between crustacea and insects in the JH receptor gene, Methoprene-tolerant.
- Hitoshi Miyakawa
- , Kenji Toyota
- & Taisen Iguchi
Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans