Innate lymphoid cells

Innate lymphoid cells (ILCs) are immune cells that belong to the lymphoid lineage but do not express antigen-specific receptors. These cells have important functions in innate immune responses to infectious microorganisms and in the regulation of homeostasis and inflammation.

Latest Research and Reviews

  • Research
    | Open Access

    Group 2 innate lymphoid cells (ILC2s) are immune cells present in adipose tissue that contribute to metabolic homeostasis. Here the authors show that Death Receptor 3 (DR3) engagement on ILC2s ameliorates glucose tolerance, protects against insulin-resistance onset and reverses established insulin-resistance.

    • Pedram Shafiei-Jahani
    • , Benjamin P. Hurrell
    • , Lauriane Galle-Treger
    • , Doumet Georges Helou
    • , Emily Howard
    • , Jacob Painter
    • , Richard Lo
    • , Gavin Lewis
    • , Pejman Soroosh
    •  & Omid Akbari
  • Research |

    Dysregulation of lung Treg cell function contributes to asthma development. Chatila and colleagues find that allergens upregulate Notch4–Hippo–Wnt signaling in Treg cells, triggering their release of GDF15 growth factor, which drives type 2 innate lymphoid cell activity and asthma.

    • Hani Harb
    • , Emmanuel Stephen-Victor
    • , Elena Crestani
    • , Mehdi Benamar
    • , Amir Massoud
    • , Ye Cui
    • , Louis-Marie Charbonnier
    • , Sena Arbag
    • , Safa Baris
    • , Amparito Cunnigham
    • , Juan Manuel Leyva-Castillo
    • , Raif S. Geha
    • , Amirhosein J. Mousavi
    • , Boris Guennewig
    • , Klaus Schmitz-Abe
    • , Constantinos Sioutas
    • , Wanda Phipatanakul
    •  & Talal A. Chatila
  • Research
    | Open Access

    Innate T cells such as iNKT, MAIT and γδ T cells all develop in the thymus, but their differentiation paths are still unclear. Here, the authors show, using single-cell RNA sequencing, that all three cell types develop via shared and branched differentiation paths that are corroborated by additional results from gene-deficient mice and human liver T cells.

    • Minji Lee
    • , Eunmin Lee
    • , Seong Kyu Han
    • , Yoon Ha Choi
    • , Dong-il Kwon
    • , Hyobeen Choi
    • , Kwanghwan Lee
    • , Eun Seo Park
    • , Min-Seok Rha
    • , Dong Jin Joo
    • , Eui-Cheol Shin
    • , Sanguk Kim
    • , Jong Kyoung Kim
    •  & You Jeong Lee
  • Research
    | Open Access

    Type 3 innate lymphoid cells (ILC3) are involved in maintaining gut immune homeostasis. Here the authors identify a circular RNA, circKcnt2, to be induced in ILC3s from inflamed gut, yet circKcnt2 deletion aggravates mouse experimental colitis, thereby implicating circKcnt2 as a potential feedback regulator of ILC3 activation and gut immunity.

    • Benyu Liu
    • , Buqing Ye
    • , Xiaoxiao Zhu
    • , Liuliu Yang
    • , Huimu Li
    • , Nian Liu
    • , Pingping Zhu
    • , Tiankun Lu
    • , Luyun He
    • , Yong Tian
    •  & Zusen Fan
  • Research
    | Open Access

    PD-1 is a checkpoint inhibitory immune receptor that restrains proliferation and effector functions of a variety of cells, including ILC2s. Here the authors present a human PD-1 agonist that limits ILC2-dependent allergic airway disease in humanized mice and provide evidence that PD-1 signaling alters ILC2 function by modulation of cell metabolism.

    • Doumet Georges Helou
    • , Pedram Shafiei-Jahani
    • , Richard Lo
    • , Emily Howard
    • , Benjamin P. Hurrell
    • , Lauriane Galle-Treger
    • , Jacob D. Painter
    • , Gavin Lewis
    • , Pejman Soroosh
    • , Arlene H. Sharpe
    •  & Omid Akbari

News and Comment