Innate immunity

Innate immunity is an immunological subsystem that comprises the cells and mechanisms that provide the first line of defence from infection in a non-specific manner. Innate immune responses are rapid and independent of antigen. Innate immune systems are found in all classes of plants and animals.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    Bile acid from intestinal symbiotic bacteria helps to resist alphavirus infection by supporting type I interferon responses by plasmacytoid dendritic cells, which in turn limit the permissiveness of circulating monocytes to viral infection.

    • Lucy Bird
  • News and Views |

    Guanylate-binding proteins (GBPs) promote immune defenses against infectious agents. Two studies reveal that GBP1 directly binds to cytosolic lipopolysaccharide (LPS), bringing caspase-4 to the surface of bacteria to induce pyroptosis.

    • Shouya Feng
    •  & Si Ming Man
    Nature Immunology 21, 829-830
  • News and Views |

    Caspase-cleaved gasdermin D forms pores in cellular membranes, thus executing proinflammatory cell death by pyroptosis. Disulfiram — a drug used to treat chronic alcoholism — is now found to be an inhibitor of pore formation, which may therapeutically counteract exacerbated inflammation in sepsis and beyond.

    • Florian I. Schmidt
    •  & Eicke Latz
    Nature Immunology 21, 718-719
  • Comments and Opinion |

    Takashi Fujita’s discovery of RNA helicases as intracellular viral replication sensors illustrates how scientific knowledge develops in logical — and sometimes illogical — ways.

    • Takashi Fujita
    Nature Immunology 21, 706-707
  • News and Views |

    The identification of the acute phase protein serum amyloid A as a soluble allergen sensor sheds new light on the mechanisms involved in the induction of type II airway inflammation.

    • Rudi W. Hendriks
    Nature Immunology 21, 724-726