Innate immune cells

Innate immune cells are white blood cells that mediate innate immunity and include basophils, dendritic cells, eosinophils, Langerhans cells, mast cells, monocytes and macrophages, neutrophils and NK cells.

Latest Research and Reviews

  • Research |

    Colonna and colleagues show that human innate lymphoid cells undergo conversion from ILC3s into ILC1-like cells in tissues in vivo.

    • Marina Cella
    • , Ramya Gamini
    • , Cristiane Sécca
    • , Patrick L. Collins
    • , Shanrong Zhao
    • , Vincent Peng
    • , Michelle L. Robinette
    • , Jorge Schettini
    • , Konstantin Zaitsev
    • , William Gordon
    • , Jennifer K. Bando
    • , Kentaro Yomogida
    • , Victor Cortez
    • , Catrina Fronick
    • , Robert Fulton
    • , Lih-Ling Lin
    • , Susan Gilfillan
    • , Richard A. Flavell
    • , Liang Shan
    • , Maxim N. Artyomov
    • , Michael Bowman
    • , Eugene M. Oltz
    • , Scott A. Jelinsky
    •  & Marco Colonna
  • Research | | open

    Promising pilot clinical trials of mesenchymal stem cells (MSCs) therapy of lupus await validation in larger, controlled trials. Here the authors show that MSCs expand CD1c+ dendritic cells in cell culture by producing FLT3L, and that in lupus patients, circulating CD1c+ dendritic cells and FLT3L are increased following MSCs therapy.

    • Xinran Yuan
    • , Xiaodong Qin
    • , Dandan Wang
    • , Zhuoya Zhang
    • , Xiaojun Tang
    • , Xiang Gao
    • , Wanjun Chen
    •  & Lingyun Sun
  • Research |

    Group 3 innate lymphoid cells are recruited to the lung and involved in the immune response to infection with tuberculosis in humans and mice, as a reduction in group 3 innate lymphoid cells in the lung impaired early immune control of Mycobacterium tuberculosis in mice.

    • Amanda Ardain
    • , Racquel Domingo-Gonzalez
    • , Shibali Das
    • , Samuel W. Kazer
    • , Nicole C. Howard
    • , Alveera Singh
    • , Mushtaq Ahmed
    • , Shepherd Nhamoyebonde
    • , Javier Rangel-Moreno
    • , Paul Ogongo
    • , Lan Lu
    • , Duran Ramsuran
    • , Maria de la Luz Garcia-Hernandez
    • , Tyler K. Ulland
    • , Matthew Darby
    • , Eugene Park
    • , Farina Karim
    • , Laura Melocchi
    • , Rajhmun Madansein
    • , Kaylesh Jay Dullabh
    • , Micah Dunlap
    • , Nancy Marin-Agudelo
    • , Takashi Ebihara
    • , Thumbi Ndung’u
    • , Deepak Kaushal
    • , Alexander S. Pym
    • , Jay K. Kolls
    • , Adrie Steyn
    • , Joaquín Zúñiga
    • , William Horsnell
    • , Wayne M. Yokoyama
    • , Alex K. Shalek
    • , Henrik N. Kløverpris
    • , Marco Colonna
    • , Alasdair Leslie
    •  & Shabaana A. Khader
    Nature, 1-5
  • Reviews |

    Neutrophils accumulate in the circulation of patients with cancer, and the neutrophil-to-lymphocyte ratio is a widely used biomarker. However, the effects of neutrophils on tumour development and progression, and the efficacy of therapies, remain relatively unknown. In this Review, the authors draw on data from animal models and patients with cancer to provide an overview of the effects of neutrophils in cancer.

    • Merav E. Shaul
    •  & Zvi G. Fridlender
  • Research | | open

    Dengue virus (DENV) promotes leukocyte-platelet interactions that contribute to pathogenesis. Here, the authors report a role for C-type lectins CLEC2 and CLEC5A in platelet activation and NET formation and show that blockade of CLEC5A and TLR2 attenuates inflammation and increases survival of infected mice.

    • Pei-Shan Sung
    • , Tur-Fu Huang
    •  & Shie-Liang Hsieh

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