Inflammation

Inflammation is a biological response to harmful stimuli, such as pathogens, damaged cells or irradiation. It is a protective attempt by the organism to remove injurious stimuli and to initiate the healing process. It is characterized by pain, redness, heat, swelling and disturbance of function.

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Latest Research and Reviews

News and Comment

  • News and Views |

    A vicious cycle, linking obesity with chronic inflammation, fuels the development and exacerbation of metabolic syndrome and other disorders. Modulation of mitochondrial energy metabolism via interleukin-1β signaling establishes a runaway positive-feedback loop that brings about and reinforces the sequelae of a high-fat diet.

    • Nektarios Tavernarakis
    Nature Immunology 21, 1143-1145
  • News and Views |

    New studies suggest that NKG7 is essential for NK and CD8+ T cell cytotoxic degranulation and CD4+ T cell activation and proinflammatory responses. While the mechanism is yet to be determined, the functional relevance is exciting and opens the possibility of a new target for cellular immunotherapies.

    • Subramaniam Malarkannan
    Nature Immunology 21, 1139-1140
  • Research Highlights |

    Histone deacetylases are typically involved in transcriptional repression, but a report in Nature describes a mechanism by which HDAC3 can also activate macrophage transcription in response to lipopolysaccharide in a deacetylase-independent manner.

    • Kirsty Minton
  • News and Views |

    Vagus nerve stimulation has shown promise in treating inflammatory bowel disease. A new study identifies a hepatic vagal branch pathway necessary to maintain colonic immune cell homeostasis in experimental colitis, challenging the dogma that an anti-inflammatory reflex requires an intact spleen and that α7-nicotinic receptor agonists are a panacea for inflammatory conditions.

    • Alan de Araujo
    •  & Guillaume de Lartigue