Inflammasome articles from across Nature Portfolio

Devant and Kagan review the biochemical and cell biological mechanisms that control gasdermin D pore-forming activity and its diverse downstream immunological effects.

NLRP3 inflammasomes trigger release of IL-1 to promote tissue injury. Here, Li et al identify a ZFYVE21-Rubicon-RNF34 (ZRR) signaling complex localizing to endosomes and modulating complement-mediated inflammasome activity in vitro and in vivo.

Structural, biochemical and mutagenesis studies indicate that, in dying cells, the membrane protein NINJ1 assembles into filaments, disrupting the cell membrane.

Here, Ting and colleagues provide an overview of the NLR gene family, detailing the initial discovery of NLRs and the key experiments that uncovered their biology. NLRs are well known for their roles as inflammasome receptors and regulators of inflammation but they also have less appreciated roles, for example, in embryogenesis and reproduction.