Infertility articles from across Nature Portfolio

The authors show that maternal high-fat diet influences offspring’s ovarian reserve through maternal-embryonic cross-talk in mice and that maternal vitamin B1 supplementation could rescue ovarian primordial follicle reserve in mouse offspring.

The mechanism of parturition initiation remains elusive. Here, authors show that epithelium is an underestimated site for parturition initiation via epithelial PGF2a regulated by SHP2-COX1/COX2.

Uninterrupted embryo culture and time-lapse monitoring are increasingly offered to people undergoing IVF — but a randomized study fails to show any benefit over routine embryo-selection methods.

The largest whole-exome sequencing study of individuals with premature ovarian insufficiency (POI) so far identifies 20 new disease-associated genes, yields an overall genetic contribution to POI of 23.5%, and provides detailed characterization of the genetic landscape of this disorder.

Over the past fifty years, intellectual property has not played a major role in the spread of assisted reproductive technology, but with in vitro gametogenesis — a technique likely to dominate the future of reproduction — it might.