Infectious diseases articles from across Nature Portfolio

Methods to detect infections are often limited to specific viruses or do not yield information on the immune response. Here, the authors analyse temporal changes in high-dimensional antibody profiles and chart more than 650 infection events across the human virome providing a high-resolution view of host-virus dynamics.

Tangirala et al. evaluate changes in the associations between various exposures and COVID-19 positivity and hospitalization across two non-consecutive waves of the pandemic in participants of the UK Biobank. They find that the strength of the association between certain risk factors, such as age and household-related factors, change over time.

Post-acute sequelae SARS-CoV-2 (PASC), also known as long COVID is a chronic and often debilitating condition that develops following acute disease. Here authors show that individuals who suffer from PASC symptoms at six month following infection are characterized by persisting immunological disfunction, affecting cellular and humoral components of mucosal immunity.