Induced pluripotent stem cells articles from across Nature Portfolio

This protocol can be used to generate kidney organoids with elongated proximalized nephrons displaying improved proximal tubule maturity compared with those generated using standard kidney organoid protocols.

The development of a kidney organoid model from induced pluripotent stem cells (iPSCs) recapitulates collagen composition from mild and severe cases of Alport syndrome, establishing a kidney organoid model aiding drug discovery.

Dynamic full-field optical coherence tomography coupled to a commercial microscope with a stage top incubator, allows non-invasive, long term, label-free longitudinal imaging of biological specimens.

The role of microglia in amyotrophic lateral sclerosis (ALS) is unclear. Here, the authors show that iPSC microglia from C9orf72-ALS patients are toxic to motor neurons and identify microglial MMP9 as a potential therapeutic target.

New traceability and reporting standards aim to improve transparency in stem cell research.

Allogeneic transplantation of cartilage organoids derived from induced pluripotent stem cells promoted cartilage repair in a primate model without eliciting immune reactions.

Human pluripotent stem cell-derived pancreatic islets (PSC-islets) hold promise in type I diabetes treatment, although their delivery is a challenge. We describe a new abdominal infusion transplantation protocol that enables the survival, maturation and maintenance of functional PSC-islets in diabetic monkeys.

We engineered a 3D outer-blood-retina-barrier (3D-oBRB) with a fully polarized retinal pigment epithelium (RPE) monolayer on top of a Bruch’s membrane and a fenestrated choriocapillaris network. This 3D-oBRB tissue faithfully recapitulates RPE– choriocapillaris interactions, dry age-related macular degeneration (AMD) phenotypes (including sub-RPE drusen deposits and choriocapillaris degeneration) and the wet AMD phenotype of choriocapillaris neovascularization.