Imprinting articles within Nature

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  • Article
    | Open Access

    In Caenorhabditis tropicalis, selective expression of genetic alleles from one parent but not the other can arise from maternally inherited small transcripts acting via the PIWI-interacting RNA host defence pathway.

    • Pinelopi Pliota
    • , Hana Marvanova
    •  & Alejandro Burga

  • Article |

    Analysis of parental allele-specific chromatin accessibility genome-wide in mouse zygotes and morula embryos, and investigation of the epigenetic mechanisms underlying these allelic sites, identifying maternal H3K27me3 as a DNA methylation-independent mechanism for genomic imprinting.

    • Azusa Inoue
    • , Lan Jiang
    •  & Yi Zhang

  • Letter |

    This study establishes an important role for the enzyme Tet1 in erasing genomic imprinting in vivo — mice with a knockout of paternal Tet1 give rise to progeny with imprinting defects and associated growth and development defects, which leads to early embryonic lethality; furthermore, analysis of the DNA methylation dynamics in reprogramming primordial germ cells (PGCs) suggests that Tet1 is required at a late stage of the reprogramming process, in the second wave of DNA demethylation in PGCs.

    • Shinpei Yamaguchi
    • , Li Shen
    •  & Yi Zhang

  • News |

    High-profile results challenged over statistical analysis of sequence data.

    • Erika Check Hayden

  • News & Views |

    A gene is considered to be imprinted if only the copy inherited from the mother or from the father is expressed throughout life. But one imprinted gene, Dlk1, disobeys this rule during postnatal neurodevelopment. See Letter p.381

    • Edwin C. Oh
    •  & Nicholas Katsanis

  • Letter |

    Genetic imprinting, or the preferential expression of a single parental allele, has typically been implicated as an influential factor during development, but whether unequal representation of one allele can influence social behaviour has not been studied. Here, it is demonstrated that the adaptor protein Grb10 is predominantly expressed from the paternal allele in brain and that ablating this allelic bias induces behavioural modifications of a social nature. At this time, Grb10 is unique in the sense that tissue-specific actions of each parental allele can influence distinct physiological or behavioural processes.

    • Alastair S. Garfield
    • , Michael Cowley
    •  & Andrew Ward

  • News & Views |

    Some genes exclusively express only their maternal or paternal copy. Studies of the brain extend the list of such imprinted genes by an order of magnitude, highlighting their spatial and temporal regulation.

    • Eric B. Keverne

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