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Implants are biomedical materials or medical devices intended to replace a missing biological structure, or support or augment the function of an existing one. Examples of implants are prostheses, dental fixtures, and birth-control subdermal capsules.
To address the inherent hydrophobic and bioinert natures of synthetic polymeric membranes, we design and construct bioinspired and osteopromotive polydopamine nanoparticle-incorporated fibrous membranes through co-electrospinning of polycaprolactone (PCL) with polydopamine nanoparticles (PDA NPs). The multifunctional membranes are demonstrated to possess prominent cytocompatibility and osteo-differentiation potential of human mesenchymal stem cells (hMSCs) without any growth factors, as well as boosted bone regeneration in vivo using a mouse calvarial critical-sized defect. Accordingly, such engineered PDA/PCL fibrous membranes, which are osteoinductive and easy to transplant, have great potential for guided tissue regeneration application.
Foreign body response can result in failure of biomaterials in vivo. Solvent-free crystals containing anti-fibrotic drugs now show the potential for long-term inhibition of fibrosis on a number of implantable devices in rodents and non-human primates.
Arthroplasty is the main clinical option for the treatment of osteoarticular lesions, but has limited efficacy. Here, the authors use a wound dressing with autologous mesenchymal stromal cells, functionalised for local BMP2 delivery, and show feasibility and safety in standardised preclinical tests in animal models, suggesting suitability for use in clinical trials.
Biofilms are communities of bacteria that accumulate on surfaces such as replacement joints or intravenous catheters. By silencing a key communication system, Staphylococcus aureus builds tightly packed biofilms that can withstand attack by host immune cells.
Neural probes that mimic the subcellular structural features and mechanical properties of neurons assimilate across several structures of the brain to provide chronically stable neural recordings in a mouse model.